Dosage of Penicil in details
Oral
Susceptible infections
Adult: 125-312 mg 4-6 hrly.
Renal impairment: Dosing interval should be no more frequent than every 8-10 hr.
Parenteral
Susceptible infections
Adult: 0.6-3.6 g daily in 4-6 divided doses, via IM, slow IV inj or infusion. Higher doses may be needed in more serious infections. IV doses >1.2 g should be given at a rate of not more than 300 mg/min.
Child: Newborn infants: 50 mg/kg daily in 2 divided doses; Renal impairment: Dosing interval should be no more frequent than every 8-10 hr. Reconstitution: Loosen the powd, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute w/ sterile water for inj, NaCl 0.9% inj or dextrose 5% inj. Incompatibility: Amphotericin B, cimetidine, cytarabine, flucloxacillin, hydroxyzine, methylprednisolone, promethazine, metoclopramide and soln containing metal ions. Bacterial endocarditis Adult: 7.2-12 g or more, given daily in divided doses. Renal impairment: Dosing interval should be no more frequent than every 8-10 hr. Reconstitution: Loosen the powd, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute w/ sterile water for inj, NaCl 0.9% inj or dextrose 5% inj. Incompatibility: Amphotericin B, cimetidine, cytarabine, flucloxacillin, hydroxyzine, methylprednisolone, promethazine, metoclopramide and soln containing metal ions. Intrapartum prophylaxis against group B Streptoccocal infection in neonates Adult: Initially, 3 g, then 1.5 g 4 hrly until delivery. Renal impairment: Dosing interval should be no more frequent than every 8-10 hr. Reconstitution: Loosen the powd, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute w/ sterile water for inj, NaCl 0.9% inj or dextrose 5% inj. Incompatibility: Amphotericin B, cimetidine, cytarabine, flucloxacillin, hydroxyzine, methylprednisolone, promethazine, metoclopramide and soln containing metal ions. Meningococcal meningitis; Pneumococcal meningitis Adult: 2.4 g 4 hrly. Max: 18 g/day in meningococcal meningitis. Doses >1.2 g should be given at a rate not more than 300 mg/min. Child: Newborn infants: 100 mg/kg daily in 2 divided doses; Renal impairment: Dosing interval should be no more frequent than every 8-10 hr. Reconstitution: Loosen the powd, then, hold the vial horizontally and rotate it while slowly directing the stream of diluent against the wall of the vial. Shake the vial vigorously after all the diluent has been added. Depending on the route of admin, reconstitute w/ sterile water for inj, NaCl 0.9% inj or dextrose 5% inj. Incompatibility: Amphotericin B, cimetidine, cytarabine, flucloxacillin, hydroxyzine, methylprednisolone, promethazine, metoclopramide and soln containing metal ions. Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use of amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin. Chloramphenicol, macrolides, sulfonamides, and tetracy-clines may interfere with the bactericidal effects of penicillin. This has been demonstrated in vitro; however, the clinical significance of this interaction is not well documented. Drug/Laboratory Test Interactions: High urine concentrations of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using CLINITEST®, Benedictís Solution, or Fehlingís Solution. Since this effect may also occur with amoxicillin, it is recommended that glucose tests based on enzymatic glucose oxi-dase reactions (such as CLINISTIX®) be used. Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. This effect may also occur with amoxicillin. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long-term studies in animals have not been performed to evaluate carcinogenic potential. Studies to detect mutagenic potential of amoxicillin alone have not been conducted; however, the following information is available from tests on a 4:1 mixture of amoxicillin and potassium clavulanate (AUGMENTIN). AUGMENTIN was non-mutagenic in the Ames bacterial mutation assay, and the yeast gene conversion assay. AUGMENTIN was weakly positive in the mouse lymphoma assay, but the trend toward increased mutation frequencies in this assay occurred at doses that were also associated with decreased cell survival. AUGMENTIN was negative in the mouse micronucleus test, and in the dominant lethal assay in mice. Potassium clavulanate alone was tested in the Ames bacterial mutation assay and in the mouse micronucleus test, and was negative in each of these assays. In a multi-generation reproduction study in rats, no impairment of fertility or other adverse reproductive effects were seen at doses up to 500 mg/kg (approximately 3 times the human dose in mg/m2). Pregnancy: Teratogenic Effects: Pregnancy Category B. Reproduction studies have been performed in mice and rats at doses up to 10 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to amoxicillin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Labor and Delivery: Oral ampicillin-class antibiotics are poorly absorbed during labor. Studies in guinea pigs showed that intravenous administration of ampicillin slightly decreased the uterine tone and frequency of contractions but moderately increased the height and duration of contractions. However, it is not known whether use of amoxicillin in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary. Nursing Mothers: Penicillins have been shown to be excreted in human milk. Penicil use by nursing mothers may lead to sensitization of infants. Caution should be exercised when amoxicillin is administered to a nursing woman. Pediatric Use: Because of incompletely developed renal function in neonates and young infants, the elimination of amoxicillin may be delayed. Dosing of AMOXIL should be modified in pediatric patients 12 weeks or younger (£3 months). (See DOSAGE AND ADMINISTRATIONñNeonates and infants.) Information checked by Dr. Sachin Kumar, MD PharmacologyIntravenous
Intravenous
Intravenous
Penicil interactions
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