Perindopril arginine/Indapamide Fisher indications
Treatment of essential hypertension.
Perindopril arginine/Indapamide Fisher 5 mg/1.25 mg: Subjects whose blood pressure is not adequately controlled by Perindopril (Perindopril arginine/Indapamide Fisher) alone.
Perindopril arginine/Indapamide Fisher 10 mg/2.5 mg: Substitution therapy in patients already controlled with Perindopril (Perindopril arginine/Indapamide Fisher) and Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher) given concurrently at the same dose level.
Perindopril arginine/Indapamide Fisher description
Each Perindopril arginine/Indapamide Fisher 2.5 mg tablet contains Perindopril (Perindopril arginine/Indapamide Fisher) argnine 2.5 mg, Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher) 0.625 mg and excipients.
Each Perindopril arginine/Indapamide Fisher 5 mg tablet contains Perindopril (Perindopril arginine/Indapamide Fisher) arginine 5 mg and Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher) 1.25 mg. It also contains the following excipients: Hydrophobic colloidal silica 0.25 mg, lactose monohydrate 61.55 mg, magnesium stearate 0.45 mg and microcrystalline cellulose 22.5 mg.
Each Perindopril arginine/Indapamide Fisher 10 mg tablet contains Perindopril (Perindopril arginine/Indapamide Fisher) arginine 10 mg and Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher) 2.5 mg.
Perindopril arginine/Indapamide Fisher dosage
Perindopril arginine/Indapamide Fisher 5 mg/1.25 mg Tablet: If blood pressure is not controlled after 1 month of treatment, the dose should be titrated to one 5 mg/1.25 mg tablet/day as a single dose, preferably to be taken in the morning and before a meal. When clinically appropriate, direct change from monotherapy to 5 mg/1.25 mg film-coated tablet may be considered.
Perindopril arginine/Indapamide Fisher 10 mg/2.5 mg Tablet: One 10 mg/2.5 mg as a single dose, preferably to be taken in the morning and before a meal.
Elderly: In elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated with Perindopril arginine/Indapamide Fisher 5 mg/1.25 mg and 10 mg/2.5 mg if renal function is normal and after considering blood pressure response.
Renal Impairment: In severe renal impairment (creatinine clearance <30 mL/min), treatment is contraindicated.
In moderate renal impairment (creatinine clearance <60 mL/min), treatment is contraindicated to Perindopril arginine/Indapamide Fisher 10 mg/2.5 mg.
Perindopril arginine/Indapamide Fisher 5 mg/1.25 mg Tablet: In patients with moderate renal impairment (creatinine clearance 30-60 mL/min), it is recommended to start treatment with the adequate dosage of the free combination.
In patients with creatinine clearance ≥60 mL/min, no dose modification is required.
Usual medical follow-up will include frequent monitoring of creatinine and potassium.
Hepatic Impairment: In severe hepatic impairment, treatment is contraindicated.
In patients with moderate hepatic impairment, no dose modification is required.
Perindopril arginine/Indapamide Fisher interactions
Avoid Perindopril arginine/Indapamide Fisher with lithium, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium salts.
Caution in use of Perindopril arginine/Indapamide Fisher with the following drugs: Other medicines for treating high blood pressure; procainamide; allopurinol; terfenadine or astemizole; corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis; immunosuppressants used for the treatment of autoimmune disorders or following transplant surgery to prevent rejection (eg, cyclosporin); medicines for the treatment of cancer; erythromycin by injection; halofantrine; pentamidine; injectable gold; vincamine; bepridil; sulfopride; medicines used for heart rhythm problems (eg, quinidine, hydroquinidine, disopyramide, amiodarone, sotalol); digoxin or other cardiac glycosides; baclofen; medicines used to treat diabetes eg, insulin or metformin; calcium, including calcium supplements; stimulant laxatives (eg, senna); nonsteroidal anti-inflammatory drugs (eg, ibuprofen) or high-dose salicylates (eg, aspirin); amphotericin B by injection; medicines to treat mental disorders eg, depression, anxiety, schizophrenia (eg, tricyclic antidepressants, neuroleptics); tetracosactide.
Perindopril arginine/Indapamide Fisher side effects
The administration of Perindopril (Perindopril arginine/Indapamide Fisher) inhibits the renin-angiotensin-aldosterone axis and tends to reduce the potassium loss caused by Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher). Two percent (2%) of the patients on treatment with Perindopril arginine/Indapamide Fisher 2.5 mg/0.625 mg, 4% of the patients on treatment with Perindopril arginine/Indapamide Fisher 5 mg/1.25 mg and 6% of the patients on treatment with Perindopril arginine/Indapamide Fisher 10 mg/2.5 mg experience hypokalaemia (potassium level <3.4 micromol/L).
The following undesirable effects could be observed during treatment and ranked under the following frequency: Very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1000, <1/100); rare (≥1/10000, <1/1000), very rare (<1/10000), not known (cannot be estimated from the available data).
Blood and the Lymphatic System Disorders: Very Rare: Thrombocytopenia, leucopenia/neutropenia, agranulocytosis, aplastic anaemia, haemolytic anaemia. Anaemia has been reported with ACE inhibitors in specific circumstances (patients who have had kidney transplants, patients undergoing haemodialysis).
Psychiatric Disorders: Uncommon: Mood or sleep disturbances.
Nervous System Disorders: Common: Paraesthesia, headache, dizziness, vertigo. Very Rare: Confusion.
Eye Disorders: Common: Vision disturbance.
Ear and Labyrinth Disorders: Common: Tinnitus.
Vascular Disorders: Common: Hypotension whether orthostatic or not.
Cardiac Disorders: Very Rare: Arrhythmia including bradycardia, ventricular tachycardia, atrial fibrillation, angina pectoris and myocardial infarction possibly secondary to excessive hypotension in high-risk patients.
Respiratory, Thoracic and Mediastinal Disorders: Common: A dry cough has been reported with the use of ACE inhibitors. It is characterised by its persistence and by its disappearance when treatment is withdrawn. An iatrogenic aetiology should be considered in the presence of this symptom. Dypsnoea. Uncommon: Bronchospasm. Very Rare: Eosinophilic pneumonia, rhinitis.
Gastrointestinal Disorders: Common: Constipation, dry mouth, nausea, vomiting, abdominal pain, dysgeusia, dyspepsia, diarrhoea, epigastric pain, anorexia, abdominal pains, taste disturbance. Very Rare: Pancreatitis.
Hepato-Biliary Disorders: Very Rare: Hepatitis either cytolytic or cholestatic. Not known: In case of hepatic insufficiency, there is a possibility of onset of hepatic encephalopathy.
Skin and Subcutaneous Tissue Disorders: Common: Rash, pruritus, maculopapular eruptions. Uncommon: Angioedema of face, extremities, lips, mucous membranes, tongue, glottis and/or larynx, urticaria. Hypersensitivity reactions, mainly dermatological, in subjects with a predisposition to allergic and asthmatic reactions. Purpura, possible aggravation of preexisting acute disseminated lupus erythematosus. Very Rare: Erythema multiforme, toxic epidermic necrolysis, Stevens-Johnson syndrome. Cases of photosensitivity reactions have been reported.
Musculoskeletal, Connective Tissue and Bone Disorders: Common: Muscle cramps.
Renal and Urinary Disorders: Uncommon: Renal insufficiency. Very Rare: Acute renal failure.
Reproductive System and Breast Disorders: Uncommon: Impotence.
General Disorders and Administration Site Conditions: Common: Asthenia. Uncommon: Sweating.
Investigations: Potassium depletion with particularly serious reduction in levels of potassium in some at risk populations. Reduced sodium levels with hypovolaemia causing dehydration and orthostatic hypotension. Increase in uric acid levels and in blood glucose levels during treatment. Slight increase in urea and in plasma creatinine levels, reversible when treatment is stopped. This increase is more frequent in cases of renal artery stenosis, arterial hypertension treated with diuretics, renal insufficiency. Increased levels of potassium, usually transitory. Rare: Raised plasma calcium levels.
Perindopril arginine/Indapamide Fisher contraindications
Linked to Perindopril (Perindopril arginine/Indapamide Fisher): Perindopril arginine/Indapamide Fisher should never be used in cases of hypersensitivity to Perindopril (Perindopril arginine/Indapamide Fisher) or to any other angiotensin-converting enzyme inhibitors; previous history of angioneurotic oedema (Quincke's oedema) linked to treatment with an angiotensin-converting enzyme inhibitor; hyperkalemia; pregnancy; lactation.
Perindopril arginine/Indapamide Fisher 2.5 mg: Hereditary or idiopathic angioneurotic oedema.
Perindopril arginine/Indapamide Fisher 2.5 mg/5 mg is generally not recommended in combinations with potassium-sparing diuretics, potassium salts, lithium; bilateral renal artery stenosis or single functioning kidney; increased potassium levels.
Linked to Indapamide (Perindopril (Perindopril arginine/Indapamide Fisher) arginine/Indapamide Fisher): Perindopril arginine/Indapamide Fisher should never be used in cases of hypersensitivity to sulphonamides; severe renal failure (creatinine clearance <30 mL/min), hepatic encephalopathy, severe impairment of liver function; hypokalaemia.
As a general rule, use of Perindopril arginine/Indapamide Fisher is not recommended in combination with non-antiarrhythmic drugs producing Torsade de pointes.
Linked to Perindopril arginine/Indapamide Fisher 2.5 mg: Hypersensitivity to any of the excipients.
As there is a lack of available data, Perindopril arginine/Indapamide Fisher 2.5 mg must not be used in dialysis patients; patients with untreated decompensated cardiac insufficiency.
Active ingredient matches for Perindopril arginine/Indapamide Fisher:
Indapamide/Perindopril in Netherlands.
List of Perindopril arginine/Indapamide Fisher substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Perindopril/Indapamide-GH 4/1.25 (Australia) | |
| Perindopryl + Indapamid Servier (Poland) | |
| Perindostad (Slovakia) | |
| Perinpa (Czech Republic) | |
| Peripil Plus (Philippines) | |
| Perivel Plus (Turkey) | |
| Perseco-Sanovel Plus (Georgia) | |
| Peryndopryl + Indapamid Servier (Poland) | |
| Pivesyl Plus (Vietnam) | |
| Pivesyl Plus 1 Blister x 30 Tablet | |
| Pontea (Bulgaria) | |
| Predonium (Hong Kong, Portugal) | |
| Predonium 30's (Servier) | |
| Predonium tab 30's (Servier) | |
| Pregamon Plus-Humanity (Georgia) | |
| Pregin Plus-Humanity (Georgia) | |
| Prelectal (Italy) | |
| Prenewel (Czech Republic, Estonia, Latvia, Lithuania, Slovenia) | |
| Prenix (Poland) | |
| Prenix N (Poland) | |
| Prestarium (Bulgaria, Czech Republic, Denmark, Estonia, Georgia, Latvia, Lithuania, Poland, Romania, Russian Federation, Slovakia) | |
| Tablet; Oral; Perindopril Erbumine 2 mg (Les lab. servier) | |
| Tablet; Oral; Perindopril Erbumine 4 mg (Les lab. servier) | |
| Tablet; Oral; Perindopril Erbumine 8 mg (Les lab. servier) | |
| Prestarium 10mg - 30 Tablets (Les lab. servier) | $ 45.00 |
| Prestarium 5mg - 30 Tablets (Les lab. servier) | $ 25.00 |
| Prestarium Combi (Georgia, Latvia) | |
| Prestarium Combi Arginine (Estonia) | |
| Prestarium Forte Combi (Slovakia) | |
| Prestarium neo combi (Czech Republic) | |
| Prestarium neo forte (Czech Republic) | |
| Prestarium Plus (Poland) | |
| Pretanix Komb 4 mg/1.25 mg (Hungary) | |
| Pretanix Komb Forte (Hungary) | |
| Pretanix Komb Forte 8 mg/2.5 mg (Hungary) | |
| Pretanix Komb. (Hungary) | |
| Preterax (Austria, Belgium, Costa Rica, Dominican Republic, El Salvador, France, Greece, Guatemala, Honduras, Ireland, Italy, Luxembourg, Malta, Mexico, Myanmar, Nicaragua, Panama, Peru, Philippines, Portugal, Singapore, South Africa, Spain, Taiwan, Turkey, Vietnam) | |
| Tablet; Oral; Indapamide 0.625 mg; Perindopril Erbumine 2 mg (Servier) | |
| Preterax 30's (Servier) | $ 32.22 |
| Preterax 28's (Servier) | |
| Preterax tab 30's (Servier) | $ 36.18 |
| Preterax tab 10 mg/2.5 mg 30's (Servier) | |
| Preterax tab 5 mg/1.25 mg 30's (Servier) | |
| Preterax tab 2.5 mg/0.625 mg 30's (Servier) | |
| Preterax 10 (Argentina) | |
| Preterax 5 (Argentina) | |
See 372 substitutes for Perindopril arginine/Indapamide Fisher | |
References
- DailyMed. "INDAPAMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "indapamide". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "PERINDOPRIL". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Perindopril arginine/Indapamide Fisher are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Perindopril arginine/Indapamide Fisher. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
