Pregnancy of Perio-Clor in details
Perio-Clor oral rinse has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity when given at high doses. There are no controlled data in human pregnancy. Perio-Clor oral rinse should only be used during pregnancy when need has been clearly established. Perio-Clor chips have been assigned to pregnancy category C by the FDA. Animal studies have not been conducted with this dosage form; however, high dosages administered by gavage were not associated with fetotoxicity. There are no controlled data in human pregnancy. Perio-Clor absorption is possible following periodontal insertion; in clinical trials systemic Perio-Clor levels were below the limit of detection. Perio-Clor chips should only be used during pregnancy when need has been clearly established.
Perio-Clor breastfeeding
One infant experienced episodes of bradycardia and cyanotic spells which may have been due to the application of Perio-Clor directly onto the mother's breast during breast-feeding. Perio-Clor was detected in the blood of the infant.
There are no data on the excretion of Perio-Clor into human milk when given as an oral rinse. Some studies have reported that any Perio-Clor ingested is poorly absorbed; therefore, excretion into breast milk is unlikely. The manufacturer recommends that caution be used when administering Perio-Clor to nursing women.
References
- DailyMed. "CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Hibiclens: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Chlorhexidine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
