Phenazone Dosage

• Dosage of Phenazone in details
• Phenazone interactions
• Phenazone reviews

Dosage of Phenazone in details

Oral

Mild to moderate pain

Adult: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.

Child: 12-15 yr: 500 mg once or bid. Max: 1 g daily. >15 yr: 500 mg to 1 g every 4-8 hr. Max: 4 g/day.

Oral

Acute migraine attacks

Adult: 1 g every 4-8 hr. Max: 4 g/day.

Child: >15 yr: 1 g every 4-8 hr. Max: 4 g/day.

Otic/Aural

Otic inflammation; Removal of earwax

Adult: 4-6 drops (0.5% solution) 3-4 times daily depending on the severity of inflammation.

Phenazone interactions

Acetaminophen is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize acetaminophen [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of acetaminophen and may decrease the action of acetaminophen. Doses of acetaminophen greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for acetaminophen to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effect of acetaminophen by decreasing its absorption into the body from the intestine. Therefore, acetaminophen should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.

Acetaminophen doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of acetaminophen should be avoided during warfarin therapy

References

1. DailyMed. "PHENYLBUTAZONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "GN5P7K3T8S: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Anti-Inflammatory Agents, Non-Steroidal". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Phenazone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Phenazone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology