• Dosage of Phenazopyridine in details
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Dosage of Phenazopyridine in details

Phenazopyridine Dosage

Applies to the following strength(s): 95 mg; 100 mg; 200 mg; 97.2 mg; 97.5 mg; 99.5 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Dysuria

Usual Pediatric Dose for:

• Dysuria

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Precautions
• Dialysis
• Other Comments

Usual Adult Dose for Dysuria

190 to 200 mg orally 3 times a day after meals. Do not administer for more than 2 days when used with a urinary antibacterial.

Usual Pediatric Dose for Dysuria

>= 6 years to 18 years:

12 mg/kg/day orally divided into 3 doses for two days. Maximum dose: 600 mg/day.

Renal Dose Adjustments

CrCl >= 50 <80 mL/min: Administer every 8 to 16 hours.

CrCl <50 mL/min: not recommended

Liver Dose Adjustments

Data not available

Precautions

Phenazopyridine should not be administered to patients with CrCl <50 mL/min. Phenazopyridine should be used with caution in patients with renal impairment.

A yellowish tinge of the skin or sclera may indicate accumulation due to renal insufficiency and the need to discontinue Phenazopyridine.

Children younger than 12 years of age should not take Phenazopyridine unless directed by a physician.

Dialysis

Data not available

Other Comments

Treatment of a urinary tract infection with Phenazopyridine and an antibacterial should not exceed 2 days as there is no evidence that Phenazopyridine provides any greater benefit than the antibacterial alone after 2 days.

The urine may present reddish-orange after use of the drug.

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Consumer resources

• Phenazopyridine
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Related treatment guides

• Dysuria
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What other drugs will affect Phenazopyridine?

There may be other drugs that can interact with Phenazopyridine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Phenazopyridine interactions

With the simultaneous use with inducers of microsomal liver enzymes, means having hepatotoxic effect, increasing the risk of hepatotoxic action of paracetamol.

With the simultaneous use of anticoagulants may be slight to moderate increase in prothrombin time.

With the simultaneous use of anticholinergics may decrease absorption of paracetamol.

With the simultaneous use of oral contraceptives accelerated excretion of paracetamol from the body and may reduce its analgesic action.

With the simultaneous use with urological means reduced their effectiveness.

With the simultaneous use of activated charcoal reduced bioavailability of paracetamol.

When Phenazopyridine applied simultaneously with diazepam may decrease excretion of diazepam.

There have been reports about the possibility of enhancing mielodepression effect of zidovudine while applying with paracetamol. A case of severe toxic liver injury.

Described cases of toxic effects of paracetamol, while the use of isoniazid.

When applied simultaneously with carbamazepine, phenytoin, phenobarbital, primidonom decreases the effectiveness of paracetamol, which is caused by an increase in its metabolism and excretion from the body. Cases of hepatotoxicity, while the use of paracetamol and phenobarbital.

In applying cholestyramine a period of less than 1 h after administration of paracetamol may decrease of its absorption.

At simultaneous application with lamotrigine moderately increased excretion of lamotrigine from the body.

With the simultaneous use of metoclopramide may increase absorption of paracetamol and its increased concentration in blood plasma.

When applied simultaneously with probenecid may decrease clearance of paracetamol, with rifampicin, sulfinpyrazone - may increase clearance of paracetamol due to increasing its metabolism in the liver.

At simultaneous application of Phenazopyridine with ethinylestradiol increases absorption of paracetamol from the gut.

Enhances the effect of indirect anticoagulants (coumarin derivatives and indandione). Antipyretic and analgesic activity of caffeine increases, reduce - rifampicin, phenobarbital and alcohol (accelerated biotransformation, inducing microsomal liver enzymes).

References

1. FDA/SPL Indexing Data. "K2J09EMJ52: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
2. MeSH. "MeSH Tree: MeSH (Medical Subject Headings) is the NLM controlled vocabulary thesaurus used for indexing articles for PubMed.". http://www.nlm.nih.gov/mesh/meshhome... (accessed September 17, 2018).
3. European Chemicals Agency - ECHA. "Phenazopyridine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology