Pregnancy of Phenylephrine HCl in details
Phenylephrine HCl crosses the placenta at term.
Maternal use of Phenylephrine HCl during the first trimester of pregnancy is not strongly associated with an increased risk of fetal malformations; maternal dose and duration of therapy were not reported in available publications. Phenylephrine HCl is available over-the-counter for the symptomatic relief of nasal congestion. Decongestants are not the preferred agents for the treatment of rhinitis during pregnancy.
Oral Phenylephrine HCl should be avoided during the first trimester of pregnancy; short-term use (<3 days) of intranasal Phenylephrine HCl may be beneficial to some patients although its safety during pregnancy has not been studied. Phenylephrine HCl injection is used at delivery for the prevention and/or treatment of maternal hypotension associated with spinal anesthesia in women undergoing cesarean section. Phenylephrine HCl may be associated with a more favorable fetal acid base status than ephedrine; however, overall fetal outcomes appear to be similar. Nausea or vomiting may be less with Phenylephrine HCl than ephedrine but is also dependent upon blood pressure control. Phenylephrine HCl may be preferred in the absence of maternal bradycardia.
Phenylephrine HCl breastfeeding
Small amounts of Phenylephrine HCl are secreted in breast milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
See references
References for pregnancy information
- "Product Information. Lusonal (Phenylephrine HCl)." Wraser Pharmaceuticals, Ridgeland, MS.
References for breastfeeding information
- "Product Information. Lusonal (Phenylephrine HCl)." Wraser Pharmaceuticals, Ridgeland, MS.
References
- PubMed Health. "Neo-Synephrine: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
- Human Metabolome Database (HMDB). "Phenylephrine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
- FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
