What happens if I overdose Phenylephrine Hydrochloride?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room right away. Symptoms may include confusion; hallucinations; irregular or unusually slow or rapid heartbeat; rapid breathing; seizures.
Proper storage of Triaminic Decongestant Infant
Orally Disintegrating Strips:
Store Triaminic Decongestant Infant
Orally Disintegrating Strips at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Triaminic Decongestant Infant
Orally Disintegrating Strips out of the reach of children and away from pets.
Overdose of Phenylephrine Hydrochloride in details
Overdosage of Phenylephrine Hydrochloride may cause a rapid rise in blood pressure. It may also cause headache, anxiety, nausea, and vomiting, and ventricular arrhythmias. Prompt injection of a rapidly acting alpha-adrenergic blocking agent such as phentolamine has been recommended.
What should I avoid while taking Phenylephrine Hydrochloride?
Do not take Phenylephrine Hydrochloride rectal rectal suppository by mouth. It is for use only in your rectum.
Ask a doctor or pharmacist before taking any cough, cold, or allergy medicine. Phenylephrine Hydrochloride is contained in many combination medicines. Taking certain products together can cause you to get too much Phenylephrine Hydrochloride. Check the label to see if a medicine contains Phenylephrine Hydrochloride, or a decongestant.
Phenylephrine Hydrochloride warnings
Topical Ophthalmic Use Only
Phenylephrine Hydrochloride ophthalmic solution 2.5% and 10% is not indicated for injection.
Cardiovascular Reactions
There have been reports of serious cardiovascular reactions, including ventricular arrhythmias and myocardial infarctions, in patients using Phenylephrine Hydrochloride 10%. These episodes, some fatal, have usually occurred in patients with pre-existing cardiovascular diseases. Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% should be used in these patients.
Elevation of Blood Pressure
A significant elevation in blood pressure is not common but has been reported following conjunctival instillation of recommended doses of Phenylephrine Hydrochloride 10%. The risk is less with Phenylephrine Hydrochloride 2.5%. Caution should be exercised with the use of Phenylephrine Hydrochloride 10% in pediatric patients less than 5 years of age and patients with hyperthyroidism, or cardiovascular disease. The post-treatment blood pressure of patients with cardiac and endocrine diseases and any patients who develop symptoms should be carefully monitored.
Rebound Miosis
Rebound miosis has been reported one day after receiving Phenylephrine Hydrochloride ophthalmic solution, and re-instillation of the drug produced a lesser mydriatic effect.
What should I discuss with my healthcare provider before taking Phenylephrine Hydrochloride?
Some medical conditions may interact with Phenylephrine Hydrochloride. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have heart disease, diabetes, phenylketonuria (PKU), an adrenal gland tumor, or thyroid disease
Some MEDICINES MAY INTERACT with Phenylephrine Hydrochloride. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Rauwolfia derivatives (eg, reserpine) or tricyclic antidepressants (eg, amitriptyline) because they may decrease Phenylephrine Hydrochloride's effectiveness
- Cocaine, furazolidone, MAOIs (eg, phenelzine), methyldopa, oxytocic medicines (eg, oxytocin), rauwolfia derivatives (eg, reserpine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Phenylephrine Hydrochloride's side effects
- Bromocriptine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), or droxidopa because the risk of their side effects may be increased by Phenylephrine Hydrochloride
- Guanethidine because its effectiveness may be decreased by Phenylephrine Hydrochloride
This may not be a complete list of all interactions that may occur. Ask your health care provider if Phenylephrine Hydrochloride may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Phenylephrine Hydrochloride precautions
Topical Ophthalmic Use Only
Phenylephrine Hydrochloride ophthalmic solution 2.5% and 10% is not indicated for injection.
Cardiovascular Reactions
There have been reports of serious cardiovascular reactions, including ventricular arrhythmias and myocardial infarctions, in patients using Phenylephrine Hydrochloride 10%. These episodes, some fatal, have usually occurred in patients with pre-existing cardiovascular diseases. Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5% should be used in these patients.
Elevation of Blood Pressure
A significant elevation in blood pressure is not common but has been reported following conjunctival instillation of recommended doses of Phenylephrine Hydrochloride 10%. The risk is less with Phenylephrine Hydrochloride 2.5%. Caution should be exercised with the use of Phenylephrine Hydrochloride 10% in pediatric patients less than 5 years of age and patients with hyperthyroidism, or cardiovascular disease. The post-treatment blood pressure of patients with cardiac and endocrine diseases and any patients who develop symptoms should be carefully monitored.
Rebound Miosis
Rebound miosis has been reported one day after receiving Phenylephrine Hydrochloride ophthalmic solution, and re-instillation of the drug produced a lesser mydriatic effect.
What happens if I miss a dose of Phenylephrine Hydrochloride?
Since Phenylephrine Hydrochloride rectal is used on an as needed basis, you are not likely to miss a dose. Do not use Phenylephrine Hydrochloride rectal more than 4 times per day.
References
- DrugBank. "phenylephrine". http://www.drugbank.ca/drugs/DB00388 (accessed September 17, 2018).
- MeSH. "Cardiotonic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- EPA Chemicals under the TSCA. "Benzenemethanol, 3-hydroxy-.alpha.-[(methylamino)methyl]- , hydrochloride (1:1), (.alpha.R)-: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
