What is Piprataz 375mg/3gr?
Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) injection is used to treat bacterial infections in many different parts of the body.
Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria and preventing their growth. However, Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) will not work for colds, flu, or other virus infections.
Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) is to be given only by or under the direct supervision of your doctor.
Piprataz 375mg/3gr indications
Piprataz 375mg/3gr is indicated for the treatment of the following systemic and/or local bacterial infections in which susceptible organisms have been detected or are suspected: Lower respiratory tract infections; urinary tract infections (complicated and uncomplicated); intra-abdominal infections; skin and skin structure infections; bacterial septicemia. Polymicrobial infections: Piprataz 375mg/3gr is indicated for polymicrobial infections including those where aerobic and anaerobic organisms are suspected (intra-abdominal, skin and skin structure, lower respiratory tract).
Piprataz 375mg/3gr, in combination with an aminoglycoside, is indicated for bacterial infections in neutropenic adults or children.
Children Under the Age of 12 Years: In hospitalized children aged 2 to 12 years, Piprataz 375mg/3gr is indicated for the treatment of intra-abdominal infections including appendicitis complicated by rupture or abscess, peritonitis, and biliary infections. It has not been evaluated in this indication for pediatric patients below the age of 2 years.
Whilst Piprataz 375mg/3gr is indicated only for the conditions listed above, infections caused by Piprataz 375mg/3gr susceptible organisms are also amendable to Piprataz 375mg/3gr treatment due to its Piprataz 375mg/3gr content. Therefore, the treatment of mixed infections caused by Piprataz 375mg/3gr susceptible organisms and β-beta lactamase producing organisms susceptible to Piprataz 375mg/3gr should not require the addition of another antibiotic.
Piprataz 375mg/3gr is particularly useful in the treatment of mixed infections and in presumptive therapy prior to the availability of the results of sensitivity tests because of its broad spectrum of activity.
Piprataz 375mg/3gr acts synergistically with aminoglycosides against certain strains of Pseudomonas aeruginosa. Combined therapy has been successful, especially in patients with impaired host defences. Both drugs should be used in full therapeutic doses. As soon as results of culture and susceptibility tests become available, antimicrobial therapy should be adjusted if necessary.
How should I use Piprataz 375mg/3gr?
Use Piprataz 375mg/3gr as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Piprataz 375mg/3gr is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Piprataz 375mg/3gr at home, a health care provider will teach you how to use it. Be sure you understand how to use Piprataz 375mg/3gr. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Piprataz 375mg/3gr if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Piprataz 375mg/3gr, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Piprataz 375mg/3gr.
Uses of Piprataz 375mg/3gr in details
Use: Labeled Indications
Intra-abdominal infections: Treatment of appendicitis complicated by rupture or abscess and peritonitis caused by beta-lactamase-producing strains of Escherichia coli, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, or Bacteroides vulgatus.
Pelvic infections: Treatment of postpartum endometritis or pelvic inflammatory disease caused by beta-lactamase-producing strains of E. coli.
Pneumonia, community-acquired: Treatment of moderate severity community-acquired pneumonia (CAP) caused by beta-lactamase-producing strains of Haemophilus influenzae.
Pneumonia, hospital-acquired (nosocomial): Treatment of moderate to severe hospital-acquired (nosocomial) pneumonia caused by beta-lactamase-producing strains of Staphylococcus aureus and by Piprataz 375mg/3gr-susceptible Acinetobacter baumannii, H. influenzae, Klebsiella pneumoniae, and P. aeruginosa.
Skin and skin structure infections: Treatment of skin and skin structure infections, including cellulitis, cutaneous abscesses, and ischemic/diabetic foot infections caused by beta-lactamase-producing strains of S. aureus.
Off Label Uses
Bite wound infection, treatment (animal or human bite)
Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTIs), Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) is an effective and recommended treatment of animal bite wound infections.
Clinical experience supports the utility of Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) in the treatment of human bite wound infections.
Piprataz 375mg/3gr description
Each 2.25 g single-dose vial contains Piprataz 375mg/3gr sodium equivalent to Piprataz 375mg/3gr 2 g and Tazobactam (Piprataz 375mg/3gr) sodium equivalent to Tazobactam (Piprataz 375mg/3gr) 0.25 g and edetate disodium (dihydrate) (EDTA) 0.5 mg.
Each 4.5 g single-dose vial contains Piprataz 375mg/3gr sodium equivalent to Piprataz 375mg/3gr 4 g and Tazobactam (Piprataz 375mg/3gr) sodium equivalent to Tazobactam (Piprataz 375mg/3gr) 0.5 g and edetate disodium (dihydrate) (EDTA) 1 mg.
Piprataz 375mg/3gr is an injectable antibacterial combination consisting of the semisynthetic antibiotic Piprataz 375mg/3gr sodium and the beta-lactamase inhibitor Tazobactam (Piprataz 375mg/3gr) sodium for intravenous administration. Piprataz 375mg/3gr sodium is derived from D(-)-a-aminobenzylpenicillin. The chemical name of Piprataz 375mg/3gr sodium is sodium (2S, 5R, 6R)-6-[(R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido] – 3,3 –dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane – 2 – carboxylate. Piprataz 375mg/3gr sodium is a white, crystalline powder. Piprataz 375mg/3gr sodium is freely soluble in water, in alcohol, and in methyl alcohol; practically insoluble in ethyl acetate. Tazobactam (Piprataz 375mg/3gr) sodium is a derivative of the penicillin nucleus. Chemically, Tazobactam (Piprataz 375mg/3gr) is a penicillanic acid sulfone. Its chemical name is sodium (2S-,3S-,5R) – 3 – methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate,4,4-dioxide. Tazobactam (Piprataz 375mg/3gr) sodium is a white to pale yellow non-hydroscopic crystalline powder.
Piprataz 375mg/3gr also contains the following excipients: Piprataz 375mg/3gr monohydrate, Tazobactam (Piprataz 375mg/3gr), sodium hydrogen carbonate, citric acid (monohydrate), EDTA, water for injections and nitrogen.
Piprataz 375mg/3gr dosage
Piprataz 375mg/3gr should be administered by intravenous infusion over 30 minutes.
The usual daily dose of Piprataz 375mg/3gr for adults is 3.375 g every six hours totaling 13.5 g (12.0 g Piprataz 375mg/3gr/1.5 g Tazobactam (Piprataz 375mg/3gr)).
Nosocomial Pneumonia
Initial presumptive treatment of patients with nosocomial pneumonia should start with Piprataz 375mg/3gr at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g Piprataz 375mg/3gr/2.0 g Tazobactam (Piprataz 375mg/3gr)). Treatment with the aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
Due to the in vitro inactivation of the aminoglycoside by beta-lactam antibiotics, Piprataz 375mg/3gr and the aminoglycoside are recommended for separate administration. Piprataz 375mg/3gr and the aminoglycoside should be reconstituted, diluted, and administered separately when concomitant therapy with aminoglycosides is indicated.
In circumstances where coadministration via Y-site is necessary, reformulated Piprataz 375mg/3gr containing EDTA supplied in Galaxy containers is compatible for simultaneous coadministration via Y-site infusion only with the following aminoglycosides under the following conditions:
The following compatibility information does not apply to the Piprataz 375mg/3gr (Piprataz 375mg/3gr) formulation not containing EDTA. This information does not apply to Piprataz 375mg/3gr in vials or bulk pharmacy containers. Refer to the package insert for Piprataz 375mg/3gr vials or bulk pharmacy containers for instructions.
| Aminoglycoside | Piprataz 375mg/3gr Dose (grams) | Aminoglycoside Concentration Range* (mg/mL) | Acceptable Diluents |
|---|---|---|---|
| Amikacin | 2.25, 3.375, 4.5 | 1.75 – 7.5 | 0.9% Sodium Chloride or 5% Dextrose |
| Gentamicin | 2.25, 3.375, 4.5 | 0.7 – 3.32 | 0.9% Sodium Chloride or 5% Dextrose |
| *The concentration ranges in Table 5 are based on administration of the aminoglycoside in divided doses (10-15 mg/kg/day in two daily doses for amikacin and 3-5 mg/kg/day in three daily doses for gentamicin). Administration of amikacin or gentamicin in a single daily dose or in doses exceeding those stated above via Y-site with Piprataz 375mg/3gr containing EDTA has not been evaluated. See package insert for each aminoglycoside for complete Dosage and Administration instructions. | |||
Piprataz 375mg/3gr is not compatible with tobramycin for simultaneous coadministration via Y-site infusion. Compatibility of Piprataz 375mg/3gr with other aminoglycosides has not been established. Only the concentration and diluents for amikacin or gentamicin with the dosages of Piprataz 375mg/3gr listed above have been established as compatible for coadministration via Y-site infusion. Simultaneous coadministration via Y-site infusion in any manner other than listed above may result in inactivation of the aminoglycoside by Piprataz 375mg/3gr.
Renal Insufficiency
In patients with renal insufficiency (Creatinine Clearance ≤ 40 mL/min), the intravenous dose of Piprataz 375mg/3gr should be adjusted to the degree of actual renal function impairment. In patients with nosocomial pneumonia receiving concomitant aminoglycoside therapy, the aminoglycoside dosage should be adjusted according to the recommendations of the manufacturer. The recommended daily doses of Piprataz 375mg/3gr for patients with renal insufficiency are as follows:
| Renal Function (Creatinine Clearance, mL/min) | All Indications (except nosocomial pneumonia) | Nosocomial Pneumonia |
|---|---|---|
| >40 mL/min | 3.375 q 6 h | 4.5 q 6 h |
| 20-40 mL/min* | 2.25 q 6 h | 3.375 q 6 h |
| <20 mL/min* | 2.25 q 8 h | 2.25 q 6 h |
| Hemodialysis** | 2.25 q 12 h | 2.25 q 8 h |
| CAPD | 2.25 q 12 h | 2.25 q 8 h |
| * Creatinine clearance for patients not receiving hemodialysis ** 0.75 g should be administered following each hemodialysis session on hemodialysis days | ||
For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g Piprataz 375mg/3gr should be administered following each dialysis period on hemodialysis days. No additional dosage of Piprataz 375mg/3gr is necessary for CAPD patients.
Duration of Therapy
The usual duration of Piprataz 375mg/3gr treatment is from seven to ten days. However, the recommended duration of Piprataz 375mg/3gr treatment of nosocomial pneumonia is 7 to 14 days. In all conditions, the duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress.
Pediatric Patients
For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended Piprataz 375mg/3gr dosage is 100 mg Piprataz 375mg/3gr/12.5 mg Tazobactam (Piprataz 375mg/3gr) per kilogram of body weight, every 8 hours. For pediatric patients between 2 months and 9 months of age, the recommended Piprataz 375mg/3gr dosage based on pharmacokinetic modeling, is 80 mg Piprataz 375mg/3gr/10 mg Tazobactam (Piprataz 375mg/3gr) per kilogram of body weight, every 8 hours. Pediatric patients weighing over 40 kg and with normal renal function should receive the adult dose. There are no dosage recommendations for Piprataz 375mg/3gr in pediatric patients with impaired renal function.
Piprataz 375mg/3gr in Galaxy containers should not be used in pediatric patients who require less than the full adult dose of Piprataz 375mg/3gr in order to prevent unintentional overdose. The other available formulations of Piprataz 375mg/3gr can be used in this population.
DIRECTIONS FOR USE OF Piprataz 375mg/3gr (Piprataz 375mg/3gr AND Tazobactam (Piprataz 375mg/3gr) INJECTION) IN GALAXY CONTAINERS (PL 2040 PLASTIC)
Piprataz 375mg/3gr Injection (PL 2040 Plastic) is to be administered using sterile equipment after thawing to room temperature.
Piprataz 375mg/3gr containg EDTA is compatible for co-administration via a Y-site intravenous tube with Lactated Ringer's injection, USP.
Administer by infusion over a period of at least 30 minutes. During the infusion it is desirable to discontinue the primary infusion solution.
Piprataz 375mg/3gr should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established.
Piprataz 375mg/3gr is not chemically stable in solutions that contain only sodium bicarbonate and solutions that significantly alter the pH.
Piprataz 375mg/3gr should not be added to blood products or albumin hydrolysates.
Piprataz 375mg/3gr interactions
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What other drugs will affect Piprataz 375mg/3gr?
The following drug interactions are chosen on the basis of their potential clinical significance:
Aminoglycosides: The mixing of Piprataz 375mg/3gr in vitro can result in substantial inactivation of the aminoglycosides.
When Piprataz 375mg/3gr is administered together with tobramycin, the AUC, renal clearance and urinary recovery of tobramycin were decreased by 11%, 32% and 38%, respectively. The alterations in the pharmacokinetics of tobramycin when administered in conjunction with Piprataz 375mg/3gr may be due to inactivation of tobramycin in the presence of Piprataz 375mg/3gr. It has been postulated that penicillin-aminoglycoside complexes form and these complexes are micobiologically inactive and unknown toxicity.
Probenecid: Probenecid administered concomitantly with Piprataz 375mg/3gr prolongs the t½ of Piprataz 375mg/3gr by 21% and that of Tazobactam (Piprataz 375mg/3gr) by 71%.
Heparin, Anticoagulants and Drugs Affecting the Blood: Coagulation parameters should be tested more frequently and monitored regularly during simultaneous administration of high doses of heparin, anticoagulants and Piprataz 375mg/3gr that may affect the blood coagulation system or the thrombocyte function.
Vecuronium: Piprataz 375mg/3gr when used concomitantly with vecuronium has been implicated in the prolongation of vecuronium's neuromuscular blockade. It is also expected that neuromuscular blockade produced by any of the nondepolarizing muscle muscle relaxants could be prolonged in the presence of Piprataz 375mg/3gr.
Methotrexate: Limited data suggest that the clearance of methotrexate is reduced when co-administered with Piprataz 375mg/3gr, due to competition for renal secretion. The impact of Tazobactam (Piprataz 375mg/3gr) on the elimination of methotrexate has not been evaluated. If Piprataz 375mg/3gr and methotrexate are administered concomitantly, serum concentrations of methotrexate as well as signs and symptoms of methotrexate toxicity should be closely monitored.
Drug/Laboratory Test Interactions: As with other penicillins, the administration of Piprataz 375mg/3gr may result in a false positive reaction of glucose in the urine using copper-reduction method (Clinitest). It is recommended that glucose tests based on enzymatic glucose oxidase reactions be used.
In patients with renal failure, Piprataz 375mg/3gr is reported to cause abnormalities in clotting time, platelet aggregation and prothrombin time that close monitoring of the patient's coagulation tests is recommended.
Piprataz 375mg/3gr side effects
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What are the possible side effects of Piprataz 375mg/3gr?
Adverse drug reactions reported with Piprataz 375mg/3gr are similar to those reported with Piprataz 375mg/3gr alone and generally are transient and mild to moderate in severity. Adverse events have been reported in about ≤10% of patients receiving parenteral Piprataz 375mg/3gr and have been severe enough to require discontinuance in ≤3% of patients.
The most common frequent adverse effects reported with Piprataz 375mg/3gr are gastrointestinal (GI) effects, headache and hypersensitivity reactions.
Hypersensitivity Reactions: Rash, pruritus and fever have been reported in up to 4% of patients receiving Piprataz 375mg/3gr. Rare reports of bronchospasm have also been reported.
Gastrointestinal Effects: Diarrhea, nausea, constipation have been reported in up to 11% of patients receiving Piprataz 375mg/3gr. Vomiting, dyspepsia, stool changes and abdominal pain can occur in up to 3%, while melena, flatulence, hemorrhage, gastritis, hiccups and ulcerative stomatitis are reported in ≤1% of patients.
Clostridium difficile-associated diarrhea and colitis or antibiotic-associated pseudomembranous colitis have been reported in at least 1 patient receiving Piprataz 375mg/3gr. Colitis may occur during or following discontinuance of anti-infective therapy and may range in severity from mild to life-threatening.
Hematologic Effects: Transient leukopenia, neutropenia and thrombocytopenia have been reported in patients receiving Piprataz 375mg/3gr for a prolonged period of time (eg, after ≥21 days) and generally were reversible, systemic symptoms (eg, fever, rigors and chills) may also occur in some patients. Epistaxis and purpura have been reported in ≤1% patients.
Hepatic Effects: Transient increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase and bilirubin can occur.
Renal Effects: Increases in serum concentrations of creatinine and blood urea nitrogen (BUN) may be observed. Urinary retention, dysuria, oliguria, hematuria and incontinence have been reported in ≤1% and proteinuria, pyuria, leukorrhea and vaginitis can also occur.
Effect on the Central Nervous System: Headache and insomnia have been reported in up to 7-8%, while agitation, dizziness and anxiety have been reported in ≤2% patients. Tremors, seizures, vertigo, confusion, hallucination, malaise and depression have been reported in ≤1% of patients receiving Piprataz 375mg/3gr. Neuromuscular excitability or seizures could occur in higher than recommended doses are given IV, especially in patients with kidney failure.
Local Reactions: Adverse reactions at the injection site have been reported in ≤1% of patients. Adverse local reactions include phlebitis, pain, inflammation, thrombophlebitis and edema.
Other Adverse Effects: Hypertension, chest pain, edema, moniliasis, rhinitis, dyspnea, hypotension, ileus, syncope and rigors have been reported in ≤2% of patients. Tachycardia, bradycardia, heart failure and myocardial infarction have been reported in at most 1%.
Piprataz 375mg/3gr contraindications
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What is the most important information I should know about Piprataz 375mg/3gr?
Piprataz 375mg/3gr and Tazobactam (Piprataz 375mg/3gr) for injection is contraindicated in patients with a history of allergic reactions to any of the penicillins, cephalosporins, or β-lactamase inhibitors.
Active ingredient matches for Piprataz 375mg/3gr:
List of Piprataz 375mg/3gr substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| PIPRATAZ 500mg/4gr | |
| PIPRATAZO (India) | |
| PIPRAVIZ-T (India) | |
| Pipraz (India) | |
| Pipraz Piperacillin 4 g, Tazobactam0.5 g. VIAL / 1 (Green Lab) | $ 6.33 |
| PIPREL (India) | |
| PIPRID-TZ (India) | |
| 1's (Intra Labs) | $ 4.39 |
| Piprid-TZ Piperacillin 4 g, tazobactam0.5 g. INJ / 1 (Intra Labs) | $ 4.39 |
| Piprid-TZ Piperacillin 4 g, tazobactam0.5 g. INJ / 1 (Intra Labs) | $ 4.39 |
| PIPROTACT (India) | |
| PIPROTIS (India) | |
| PIPSAFE-T (India) | |
| Piptabac (Mexico) | |
| PIPTAC (India) | |
| 1's (Indkus) | $ 7.83 |
| Piptac Piperacillin 4 g, tazobactam0.5 g. VIAL / 1 (Indkus) | $ 7.83 |
| Piptac Piperacillin 4 g, tazobactam0.5 g. VIAL / 1 (Indkus) | $ 7.83 |
| PIPTAM (India) | |
| Piptam 4.5gm Injection (Phoenix) | $ 5.42 |
| PIPTAMATE (India) | |
| 1's (Baxter) | $ 9.04 |
| Piptamate Piperacillin 4gm, Tazobactam500mg VIAL / 1 (Baxter) | $ 9.04 |
| Piptamate Piperacillin 4gm, Tazobactam500mg VIAL / 1 (Baxter) | $ 9.04 |
| Piptason (India) | |
| Piptason Piperacillin sodium 4 g, tazobactam 0.5 g. POWD / 1 (Intellect) | $ 5.42 |
| PIPTAZ (India, Philippines) | |
| PIPTAZ Injection / 4g - 500mg / 4.5gm units (UAP) | $ 7.96 |
| PIPTAZ Injection / 2g - 250mg / 2.25g units (UAP) | $ 4.75 |
| Piptaz Piperacillin Na 4g, Tazobactam0.5g VIAL / 1 (UAP) | $ 8.06 |
| Piptaz Piperacillin Na 2g, Tazobactam250mg VIAL / 1 (UAP) | $ 5.22 |
| 1's (UAP) | $ 5.22 |
| Piptaz / vial 2 g/250 mg x 1's (UAP) | $ 14.68 |
| Piptaz 4 g/500 mg x 1's (UAP) | $ 25.54 |
| Piptaz 1 Bottle (UAP) | |
| PIPTAZ 2000 MG/250 MG INJECTION 1 vial / 10 ML injection each (UAP) | $ 5.22 |
| PIPTAZ 4000 MG/500 MG INJECTION 1 vial / 20 ML injection each (UAP) | $ 9.02 |
| Piptaz Piperacillin Na 4g, Tazobactam0.5g VIAL / 1 (UAP) | $ 8.06 |
| Piptaz Piperacillin Na 2g, Tazobactam250mg VIAL / 1 (UAP) | $ 5.22 |
| Piptaz 2000 mg/250 mg Injection (UAP) | $ 0.52 |
| Piptaz 2000mg/250mg Injection (UAP) | $ 1.64 |
| Piptaz 4.5gm Injection (UAP) | $ 7.11 |
| Piptaz 4000 mg/500 mg Injection (UAP) | $ 0.45 |
| Piptaz 4000mg/500mg Injection (UAP) | $ 3.07 |
| PipTaz-AFT (Australia) | |
| Piptazone (India, Philippines) | |
| Piptazone Piperacillin 1g, Tazobactam125mg INJ / 1 (Galpha) | $ 1.07 |
| Piptazone Piperacillin 4g, Tazobactam0.5g INJ / 1 (Galpha) | $ 2.28 |
| PIPTAZONE 4000MG/500MG INJECTION 1 vial / 1 injection each (Galpha) | $ 2.50 |
| PIPTAZONE INJECTION 1 vial / 1 injection each (Galpha) | $ 1.17 |
See 1079 substitutes for Piprataz 375mg/3gr | |
References
- PubChem. "piperacillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- PubChem. "Tazobactam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Tazobactam". http://www.drugbank.ca/drugs/DB01606 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
