What is Prépacol?
Prépacol (Prépacol) is a laxative that stimulates bowel movements.
Prépacol is used to treat constipation or to empty the bowels before surgery, colonoscopy, x-rays, or other intestinal medical procedure.
Prépacol tablets generally produce a bowel movement in 6 to 12 hours. Prépacol suppositories generally produces bowel movements in 15 minutes to 1 hour.
Prépacol indications
Prépacol is a laxative that stimulates bowel movements.
Prépacol is used to treat constipation or to empty the bowels before surgery, colonoscopy, x-rays, or other intestinal medical procedure.
How should I use Prépacol?
Use Prépacol enema as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before and after using Prépacol enema.
- Lie on left side with knee bent and arms resting comfortably. You may also kneel, then lower head and chest forward until left side of face is resting on surface with left arm folded comfortably.
- Remove protective shield from enema tip.
- Gently insert enema tip into rectum using steady pressure with a slight side-to-side movement, with tip pointing toward navel. Do not force the enema tip into rectum because this can cause injury. Insertion may be easier if you bear down as if having a bowel movement because this helps to relax the muscles around the anus.
- Squeeze bottle until nearly all the liquid is gone. It is not necessary to empty the bottle completely because it contains more liquid than needed.
- Remove enema from rectum and maintain position until the urge to evacuate the bowels is strong (5 to 20 minutes if possible).
- Drinking extra fluids while you are taking Prépacol enema is recommended. Check with your doctor for instructions.
- If you miss a dose of Prépacol enema and are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Prépacol enema.
Uses of Prépacol in details
Prépacol is used to treat constipation. It may also be used to clean out the intestines before a bowel examination/surgery. Prépacol is known as a stimulant laxative. It works by increasing the movement of the intestines, helping the stool to come out.
How to use Prépacol
Take this medication by mouth as directed by your doctor. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.
Swallow this medication whole. Do not crush, chew, or break the tablet or take it within 1 hour of antacids, milk, or milk products. Doing so can destroy the coating on the tablet and may increase the risk of stomach upset and nausea.
Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take this medication for more than 7 days unless directed by your doctor. Serious side effects may occur with overuse of this medication.
It may take 6 to 12 hours before this medication causes a bowel movement. Tell your doctor if your condition persists or worsens, or if bleeding from the rectum occurs. If you think you may have a serious medical problem, seek immediate medical attention.
Prépacol description
Prépacol may also contain the following excipients: Tablet: Lactose monohydrate, dried and undried maize starch, glycerol, magnesium stearate, crystallized sugar, talc, acacia, titanium dioxide, methacrylic acid-methyl methacrylate copolymer (1:1) and (1:2), PEG 6000, ferric oxide yellow (E172), beeswax white, carnauba wax, dibutyl phthalate, p-hydroxybenzoic acid methyl ester, p-hydroxybenzoic acid propyl ester. Suppositories: Hard fat Witepsol W45, E76.
Prépacol is 4,4'-diacetoxy-diphenyl-(pyridyl-2)-methane.
Prépacol dosage
Prépacol Dosage
Applies to the following strength(s): 5 mg; 10 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Bowel Preparation
- Constipation
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dialysis
- Other Comments
Usual Adult Dose for Bowel Preparation
5 to 15 mg (1 to 3 tablets) orally once a day as needed or
10 mg (1 suppository) rectally once a day as needed or
10 mg rectal liquid once a day as needed.
Usual Adult Dose for Constipation
5 to 15 mg (1 to 3 tablets) orally once a day as needed or
10 mg (1 suppository) rectally once a day as needed or
10 mg rectal liquid once a day as needed.
Renal Dose Adjustments
No adjustment recommended.
Caution is recommended when using Prépacol enemas containing monobasic or dibasic Prépacol in patients with impaired renal function or where colostomy exists as hypocalcemia, hyperphosphatemia, hypernatremia, and acidosis may occur.
Liver Dose Adjustments
No adjustment recommended
Dialysis
No adjustment recommended
Other Comments
Alleviation of constipation can be expected within 8 to 12 hours if taken at bedtime or within 6 hours if taken during waking hours.
More about Prépacol
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Espanol
- 526 Reviews - Add your own review/rating
Consumer resources
- Prépacol
- Prépacol enema
- Prépacol suppositories
- Prépacol oral and rectal
- Other brands: Prépacol, Correctol, Bisac-Evac, Prépacol Laxative, More (13) »
Professional resources
- Prépacol (AHFS Monograph)
- More (2) »
Related treatment guides
- Constipation
- Bowel Preparation
Prépacol interactions
See also:
What other drugs will affect Prépacol?
Antacids: May diminish the therapeutic effect of Prépacol. Antacids may cause the delayed-release Prépacol tablets to release drug prior to reaching the large intestine. Gastric irritation and/or cramps may occur. Management: Antacids should not be used within 1 hour before Prépacol administration. Consider therapy modification
Dichlorphenamide: Laxatives may enhance the hypokalemic effect of Dichlorphenamide. Monitor therapy
Polyethylene Glycol-Electrolyte Solution: Prépacol may enhance the adverse/toxic effect of Polyethylene Glycol-Electrolyte Solution. Monitor therapy
Prépacol side effects
See also:
What are the possible side effects of Prépacol?
Applies to Prépacol: oral tablets delayed-release, rectal suppositories, rectal suspension
Side effects include:
Some degree of abdominal discomfort, nausea, cramps, griping, and/or faintness with therapeutic doses.
Diarrhea, GI irritation, and fluid and electrolyte depletion.
Gastric irritation and the possibility of vomiting if enteric coating of tablets is disrupted.
Rectal administration of Prépacol (the active ingredient contained in Prépacol Uniserts) suspensions or suppositories may cause irritation and a sensation of burning of the rectal mucosa and mild proctitis.
Hepatotoxicity if sufficient tannic acid is absorbed from Prépacol tannex.
Prépacol contraindications
See also:
What is the most important information I should know about Prépacol?
Hypersensitivity to any component.
- Colopathies organic inflammatory (ulcerative colitis, Crohn’s disease...).
- Subocclusif occlusive syndrome.
- Abdominal pain syndromes of unknown cause.
- States of severe dehydration with electrolyte depletion.
RECOMMENDED:
- Pregnancy: there is no reliable data on teratogenesis in animals. Clinically, there is currently no adequate data to evaluate a possible effect of malformation or Prépacol fetotoxic when administered during pregnancy. Consequently, the use of Prépacol is not recommended during pregnancy. This item does not recommend a systematic argument for abortion, but leads to an attitude of caution and a prenatal care oriented.
- Breast-feeding: Because it passes through breast milk, the use of Prépacol is discouraged.
- Concomitant use not recommended: medication torsade de pointes (amiodarone, astemizole, bepridil, bretylium, disopyramide, erythromycin IV, halofantrine, pentamidine, quinidine, sparfloxacin, sotalol, sultopride, terfenadine, vincamine).
Active ingredient matches for Prépacol:
Bisacodyl in France.
4 Tablets, bisacodyl/monobasic sodium phosphate/oral solution, dibasic sodium phosphate in France, Austria, Germany, Czech Republic.
Sodium Phosphate in France.
| Unit description / dosage (Manufacturer) | Price, USD |
| Tablet, Film-Coated; Oral; Bisacodyl 5 mg / Solution; Oral; Sodium Phosphate Dibasic Anhydrous 9.54 g; Sodium Phosphate Monobasic Anhydrous 41.74 g / 100 ml | |
List of Prépacol substitutes (brand and generic names): | |
| Prontonema (Uruguay) | |
| Purgo Pil (Belgium, Luxembourg) | |
| Purgo-Pil (Belgium) | |
| Puritone Bisacodyl Laxative (South Africa) | |
| Pyrilax (Germany) | |
| Dragee, Gastro-Resistant; Oral; Bisacodyl 5 mg (Berlin-chemie) | |
| Suppositories; Rectal; Bisacodyl 10 mg (Berlin-chemie) | |
| Pyroscint 60 mg (Hungary) | |
| Qing Ke Long (China) | |
| ratio-Bisacodyl (Canada) | |
| Suppositories; Rectal; Bisacodyl 10 mg | |
| Ratio-bisacodyl suppository 10 mg (Teva Canada Limited (Canada)) | |
| Razilax 10 | |
| Rectanal (Poland) | |
| Reliable Gentle Laxative Tablets (United States) | |
| Rhabarex B (Germany) | |
| RISS (Thailand) | |
| RISS 90 mL | |
| S.L. Laxative (Singapore) | |
| S.L. Laxative 5 mg x 1's | |
| Sabax Fosenema (South Africa) | |
| Sacodil (Italy) | |
| Saflax (India) | |
| Saflax 5mg TAB / 100 (Psyco Remedies.) | $ 0.96 |
| 5 mg x 100's (Psyco Remedies.) | $ 0.96 |
| Saflax 5 mg Tablet (Psyco Remedies.) | $ 0.01 |
| SAFLAX tab 5 mg x 10's (Psyco Remedies.) | $ 0.10 |
| Satolax (Japan) | |
| Sekolaks (Turkey) | |
| Silaxa (Argentina, Czech Republic, Portugal) | |
| Silver Bullet | |
| Suppositories; Rectal; Bisacodyl 10 mg | |
| Sodaphos (Australia) | |
| Sodilaxan (Argentina) | |
| Sodio Fosfato Angenerico (Italy) | |
| Sodio Fosfato QualiFarma (Italy) | |
| Sodio Fosfato Ramini (Italy) | |
| Sodio Fosfato Sella (Italy) | |
| Sodium Acid Phosphate (Malta, New Zealand) | |
| Sodium Acid Phosphate Biomed (New Zealand) | |
| Sodium Acid Phosphate Chimico (Malta) | |
| Sodium Acid Phosphate Enema (Malta) | |
| Sodium Phosphate (Belgium, Brazil, Canada, Chile, China, Ecuador, Greece, Hong Kong, Indonesia, Israel, Luxembourg, Malaysia, Peru, Philippines, Singapore, Taiwan, Turkey, United States, Vietnam) | |
| Tablet; Oral; Sodium Phosphate Dibasic 6 x (Godjay Labs) | |
| Liquid; Sublingual; Sodium Phosphate Dibasic 1 x / ml (Godjay Labs) | |
| SODIUM PHOSPHATE / GODJAY enema 100ml (Godjay Labs) | $ 0.43 |
| Sodium Phosphate, P-32 | |
| Solution; Injection, Oral; Sodium Phosphate, P-32 0.67 MCI / ml | |
| Solution; Injection, Sodium Phosphate, P-32 Oral; 1.5 MCI | |
| Sodium Phosphates Sandoz (Canada) | |
See 889 substitutes for Prépacol | |
References
- DailyMed. "BISACODYL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "bisacodyl". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Bisacodyl". http://www.drugbank.ca/drugs/DB09020 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Prépacol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Prépacol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
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Information checked by Dr. Sachin Kumar, MD Pharmacology
