Pregnancy of Pro in details
Pro crosses the placenta; serum concentrations in the fetus are similar to those in the mother (Grosso 2005).
Based on current studies, usual dietary exposure to Pro is unlikely to cause congenital malformations (Brent 2011). However, available data show conflicting results related to maternal Pro use and the risk of other adverse events, such as spontaneous abortion or growth retardation (Brent 2011; Jahanfar 2013; Nehlig 1994). Chronic maternal consumption of high amounts of Pro during pregnancy may lead to neonatal withdrawal at delivery (eg, apnea, irritability, jitteriness, vomiting) (Martin 2007).
The half-life of Pro is prolonged during the second and third trimesters of pregnancy and maternal and fetal exposure is also influenced by maternal tobacco or alcohol consumption (Brent 2011; Koren 2000). Current guidelines recommend limiting Pro intake from all sources to ≤200 mg/day during pregnancy (ACOG 2010).
Pro breastfeeding
Pro citrate is not indicated for use in adult patients. Excreted into human milk: Yes Comments: -Pro readily crosses the placenta into the fetal circulation. -Breastfeeding mothers of infants receiving Pro citrate should not ingest Pro-containing foods, beverages, and medicinal products.
See references
References for pregnancy information
- "Product Information. Cafcit (Pro)" Roxane Laboratories Inc, Columbus, OH.
References for breastfeeding information
- "Product Information. Cafcit (Pro)" Roxane Laboratories Inc, Columbus, OH.
References
- DailyMed. "PIROXICAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Promethazine (Into the rectum) (Phenadoz): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
