What is Procaine Hydrochloride?
Procaine Hydrochloride (Procaine Hydrochloride) is a local anesthetic. Procaine Hydrochloride causes loss of feeling (numbness) of skin and mucous membranes.
Procaine Hydrochloride is used as an injection during surgery and other medical and dental procedures.
Procaine Hydrochloride may also be used for purposes other than those listed here.
Procaine Hydrochloride indications
local anaesthesia
How should I use Procaine Hydrochloride?
Your healthcare provider will administer Procaine Hydrochloride as an injection.
Uses of Procaine Hydrochloride in details
Procaine Hydrochloride is used for inducing local anaesthesia (loss of sensation) during surgical operations, dental procedures or other such medical procedures.
Procaine Hydrochloride description
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
Procaine Hydrochloride dosage
Procaine Hydrochloride Dosage
Generic name: Procaine Hydrochloride
Dosage form: injection, USP
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
As with all local anesthetics, the dose of Procaine Hydrochloride varies and depends upon the area to be anesthetized, the vascularity of the tissues, the number of neuronal segments to be blocked, individual tolerance, and the technique of anesthesia. The lowest dose needed to provide effective anesthesia should be administered. For specific techniques and procedures, refer to standard textbooks.
| Extent of Anesthesia | Procaine Hydrochloride 10% Solution | Total Dose (mg) | Site of Injection (lumbar interspace) | |
| Volume of 10% Solution (mL) | Volume of Dilution (mL) | |||
| Perineum | 0.5 | 0.5 | 50 | 4th |
| Perineum and lower extremities | 1 | 1 | 100 | 3rd or 4th |
| Up to costal margin | 2 | 1 | 200 | 2nd, 3rd or 4th |
The diluent may be sterile normal saline, sterile distilled water, spinal fluid; and for hyperbaric technique, sterile dextrose solution.
The usual rate of injection is 1 mL per 5 seconds. Full anesthesia and fixation usually occur in 5 minutes.
STERILIZATION
The drug in intact ampuls is sterile. The preferred method of destroying bacteria on the exterior of ampuls before opening is heat sterilization (autoclaving). Immersion in antiseptic solution is not recommended.
Autoclave at 15-pound pressure, at 121°C (250°F), for 15 minutes. The diluent dextrose may show some brown discoloration due to caramelization.
Protect solutions from light.
More about Procaine Hydrochloride (Procaine Hydrochloride)
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Professional resources
- Procaine Hydrochloride (AHFS Monograph)
- Procaine Hydrochloride (FDA)
Related treatment guides
- Local Anesthesia
Procaine Hydrochloride interactions
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What other drugs will affect Procaine Hydrochloride?
Anticholinesterases
Concurrent use of Procaine Hydrochloride and anticholinesterase agents may result in increased systemic toxicity since anticholinesterases inhibit the breakdown of Procaine Hydrochloride.
Antimyasthenics
Concurrent use of Procaine Hydrochloride and antimyasthenics may result in loss of control of symptoms of myasthenia gravis due to antagonism of the effects of antimyasthenics on skeletal muscle. Temporary dosage adjustment of antimyasthenics may be required. Also antimyasthenics may have anticholinesterase activity.
CNS depressant medications
Concurrent use of Procaine Hydrochloride and CNS depressant medications may result in additive depressant effects.
Hyaluronidase
Hyaluronidase may increase the diffusion rate of Procaine Hydrochloride, resulting in a decreased time of onset, but an increase in systemic toxicity.
Neuromuscular blocking agents (such as suxamethonium chloride)
Concurrent use of Procaine Hydrochloride and neuromuscular blocking agents may result in prolongation or enhancement of the neuromuscular blockade.
Sulfonamides
Concurrent use of Procaine Hydrochloride and sulfonamides may result in a reduction of the antibacterial action of the sulfonamide.
Acetazolamide
Concurrent use of acetazolamide and Procaine Hydrochloride may extend the plasma half-life of Procaine Hydrochloride.
Procaine Hydrochloride side effects
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What are the possible side effects of Procaine Hydrochloride?
Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels due to excessive dosage, rapid absorption, or inadvertent intravascular injection. In addition, use of inappropriate doses or techniques may result in extensive spinal blockade leading to hypotension and respiratory arrest.
A small number of reactions may result from hypersensitivity, idiosyncrasy, or diminished tolerance to normal dosage.
Excitatory CNS effects (nervousness, dizziness, blurred vision, tremors) commonly represent the initial signs of local anesthetic systemic toxicity. However, these reactions may be very brief or absent in some patients in which case the first manifestation of toxicity may be drowsiness or convulsions merging into unconsciousness and respiratory arrest.
Cardiovascular system reactions include depression of the myocardium, hypotension (or sometimes hypertension), bradycardia, and even cardiac arrest.
Allergic reactions are characterized by cutaneous lesions of delayed onset, or urticaria, edema, and other manifestations of allergy. The detection of sensitivity by skin testing is of limited value. As with other local anesthetics, hypersensitivity, idiosyncrasy and anaphylactoid reactions have occurred rarely. The reaction may be abrupt and severe and is not usually dose related.
The following adverse reactions may occur with spinal anesthesia: Central Nervous System: postspinal headache, meningismus, arachnoiditis, palsies, or spinal nerve paralysis. Cardiovascular: hypotension due to vasomotor paralysis and pooling of the blood in the venous bed. Respiratory: respiratory impairment or paralysis due to the level of anesthesia extending to the upper thoracic and cervical segments. Gastrointestinal: nausea and vomiting.
Treatment of Reactions. Toxic effects of local anesthetics require symptomatic treatment: there is no specific cure. The physician should be prepared to maintain an airway and to support ventilation with oxygen and assisted or controlled respiration as required. Supportive treatment of the cardiovascular system includes intravenous fluids and, when appropriate, vasopressors (preferably those that stimulate the myocardium, such as ephedrine). Convulsions may be controlled with oxygen and by the intravenous administration of diazepam or ultrashort-acting barbiturates or a short-acting muscle relaxant (succinylcholine).
Intravenous anticonvulsant agents and muscle relaxants should only be administered by those familiar with their use and only when ventilation and oxygenation are assured. In spinal and epidural anesthesia, sympathetic blockade also occurs as a pharmacological reaction, resulting in peripheral vasodilation and often hypotension. The extent of the hypotension will usually depend on the number of dermatomes blocked. The blood pressure should therefore be monitored in the early phases of anesthesia. If hypotension occurs, it is readily controlled by vasoconstrictors administered either by the intramuscular or the intravenous route, the dosage of which would depend on the severity of the hypotension and the response to treatment.
Procaine Hydrochloride contraindications
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What is the most important information I should know about Procaine Hydrochloride?
Spinal anesthesia with Procaine Hydrochloride is contraindicated in patients with generalized septicemia: sepsis at the proposed injection site; certain diseases of the cerebrospinal system, e.g., meningitis, syphilis; and a known hypersensitivity to the drug, drugs of a similar chemical configuration, or aminobenzoic acid or its derivatives.
The decision as to whether or not spinal anesthesia should be used in an individual case should be made by the physician after weighing the advantages with the risks and possible complications.
Active ingredient matches for Procaine Hydrochloride:
Procaine Hydrochloride
List of Procaine Hydrochloride substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Procaïne chlorhydrate Lavoisier (France) | |
| Injectable; Injection; Procaine Hydrochloride 20 mg / ml | |
| Procaine Hcl (Malaysia) | |
| Procaine HCl 20 mg/1 mL x 20 mL | |
| Procaine HCL Sterop (Belgium) | |
| Procaine Hydrochloride 1% Kobayashi (Japan) | |
| Procaine Hydrochloride Demo (Greece) | |
| Procaine Hydrochloride Hoei (Japan) | |
| Procaine Hydrochloride Injection (Australia, New Zealand) | |
| Procaine Hydrochloride Maruishi (Japan) | |
| Procaine Hydrochloride Mylan (Japan) | |
| Procaine Hydrochloride Nisshin Seiyaku - Yamagata (Japan) | |
| Procaine Hydrochloride Towa Yakuhin (Japan) | |
| Procaine Hydrochloride Yamazen Seiyaku (Japan) | |
| Procaine Sterop-1% (Luxembourg) | |
| Procaine, Base | |
| Procaine-New Asiatic (China) | |
| Procaine-Stella (Luxembourg) | |
| Procainova (Colombia) | |
| Procamidor (Austria, Finland, France, Germany, Italy) | |
| Procamidor 20 mg/ml (Austria, Netherlands) | |
| Procamidor vet (Iceland) | |
| Procanest (Argentina) | |
| Procanin (Japan) | |
| Procanin 1000's | |
| Procanine 0.5% (Japan) | |
| Procanine 1% (Japan) | |
| Procasel (Germany) | |
| Procasel-2% (Germany) | |
| Prodacid | |
| Injectable; Injection; Procaine Hydrochloride 10 mg / ml | |
| Injectable; Injection; Procaine Hydrochloride 20 mg / ml | |
| Prokain (Hungary) | |
| Prokain-Hidroklorid Teva 10 mg/ml (Hungary) | |
| Rocain (Japan) | |
| Rocain 1% (Japan) | |
| Rocain 2% (Japan) | |
| Scurocaine | |
| Solution of Novocain (Georgia) | |
| Spinocaine | |
| Stoff H3 | |
| Syntocaine (Switzerland) | |
| Venocaina (Spain) | |
| Vina-H3 (Vietnam) | |
| Vina-H3 5 mL x 12 tube | |
| Vitamin H3 | |
See 187 substitutes for Procaine Hydrochloride | |
References
- PubChem. "procaine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "procaine". http://www.drugbank.ca/drugs/DB00721 (accessed September 17, 2018).
- DTP/NCI. "procaine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
