What are the possible side effects of Procaine Hydrochloride?
Stop using Procaine Hydrochloride and seek emergency medical attention or contact your doctor immediately if you experience any of the following rare but serious side effects:
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an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
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chest pain or slow or irregular heartbeats;
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dizziness or drowsiness;
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anxiety or restlessness;
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nausea or vomiting; or
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trembling, shaking, or seizures (convulsions).
Other less serious side effects such as numbness, tingling, or minor pain at or around the injection site are more likely to occur. Contact your healthcare provider if these effects seem excessive or prolonged.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Side effects of Procaine Hydrochloride in details
Systemic adverse reactions involving the central nervous system and the cardiovascular system usually result from high plasma levels due to excessive dosage, rapid absorption, or inadvertent intravascular injection. In addition, use of inappropriate doses or techniques may result in extensive spinal blockade leading to hypotension and respiratory arrest.
A small number of reactions may result from hypersensitivity, idiosyncrasy, or diminished tolerance to normal dosage.
Excitatory CNS effects (nervousness, dizziness, blurred vision, tremors) commonly represent the initial signs of local anesthetic systemic toxicity. However, these reactions may be very brief or absent in some patients in which case the first manifestation of toxicity may be drowsiness or convulsions merging into unconsciousness and respiratory arrest.
Cardiovascular system reactions include depression of the myocardium, hypotension (or sometimes hypertension), bradycardia, and even cardiac arrest.
Allergic reactions are characterized by cutaneous lesions of delayed onset, or urticaria, edema, and other manifestations of allergy. The detection of sensitivity by skin testing is of limited value. As with other local anesthetics, hypersensitivity, idiosyncrasy and anaphylactoid reactions have occurred rarely. The reaction may be abrupt and severe and is not usually dose related.
The following adverse reactions may occur with spinal anesthesia: Central Nervous System: postspinal headache, meningismus, arachnoiditis, palsies, or spinal nerve paralysis. Cardiovascular: hypotension due to vasomotor paralysis and pooling of the blood in the venous bed. Respiratory: respiratory impairment or paralysis due to the level of anesthesia extending to the upper thoracic and cervical segments. Gastrointestinal: nausea and vomiting.
Treatment of Reactions. Toxic effects of local anesthetics require symptomatic treatment: there is no specific cure. The physician should be prepared to maintain an airway and to support ventilation with oxygen and assisted or controlled respiration as required. Supportive treatment of the cardiovascular system includes intravenous fluids and, when appropriate, vasopressors (preferably those that stimulate the myocardium, such as ephedrine). Convulsions may be controlled with oxygen and by the intravenous administration of diazepam or ultrashort-acting barbiturates or a short-acting muscle relaxant (succinylcholine).
Intravenous anticonvulsant agents and muscle relaxants should only be administered by those familiar with their use and only when ventilation and oxygenation are assured. In spinal and epidural anesthesia, sympathetic blockade also occurs as a pharmacological reaction, resulting in peripheral vasodilation and often hypotension. The extent of the hypotension will usually depend on the number of dermatomes blocked. The blood pressure should therefore be monitored in the early phases of anesthesia. If hypotension occurs, it is readily controlled by vasoconstrictors administered either by the intramuscular or the intravenous route, the dosage of which would depend on the severity of the hypotension and the response to treatment.
What is the most important information I should know about Procaine Hydrochloride?
Since there will be decreased sensation of the area where Procaine Hydrochloride is injected, use caution to avoid injury to the area during and following treatment.
Procaine Hydrochloride contraindications
Spinal anesthesia with Procaine Hydrochloride is contraindicated in patients with generalized septicemia: sepsis at the proposed injection site; certain diseases of the cerebrospinal system, e.g., meningitis, syphilis; and a known hypersensitivity to the drug, drugs of a similar chemical configuration, or aminobenzoic acid or its derivatives.
The decision as to whether or not spinal anesthesia should be used in an individual case should be made by the physician after weighing the advantages with the risks and possible complications.
References
- DTP/NCI. "procaine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Procaine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
- HSDB. "PROCAINE". https://toxnet.nlm.nih.gov/cgi-bin/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Procaine Hydrochloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Procaine Hydrochloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported side effects
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Information checked by Dr. Sachin Kumar, MD Pharmacology
