What is Prodent Forte 20?
Prodent Forte 20 is a nonsteroidal anti-inflammatory drug (NSAID). Prodent Forte 20 works by reducing hormones that cause inflammation and pain in the body.
Prodent Forte 20 is used short-term (5 days or less) to treat moderate to severe pain.
Prodent Forte 20 may also be used for purposes not listed in this medication guide.
Prodent Forte 20 indications
Carefully consider the potential benefits and risks of Prodent Forte 20 Tromethamine and other treatment options before deciding to use Prodent Forte 20. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Acute Pain in Adult Patients
Prodent Forte 20 Tromethamine is indicated for the short-term (≤5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of Prodent Forte 20 Tromethamine, and oral Prodent Forte 20 Tromethamine is to be used only as continuation treatment, if necessary.
The total combined duration of use of Prodent Forte 20 Tromethamine injection and oral Prodent Forte 20 Tromethamine is not to exceed 5 days of use because of the potential of increasing the frequency and severity of adverse reactions associated with the recommended doses. Patients should be switched to alternative analgesics as soon as possible, but Prodent Forte 20 Tromethamine therapy is not to exceed 5 days.
Prodent Forte 20 Tromethamine injection has been used concomitantly with morphine and meperidine and has shown an opioid-sparing effect. For breakthrough pain, it is recommended to supplement the lower end of the Prodent Forte 20 Tromethamine injection dosage range with low doses of narcotics prn, unless otherwise contraindicated. Prodent Forte 20 Tromethamine injection and narcotics should not be administered in the same syringe.
How should I use Prodent Forte 20?
Use Prodent Forte 20 spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Prodent Forte 20 spray comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Prodent Forte 20 spray refilled.
- Do not take Prodent Forte 20 spray by mouth. Use in your nose only.
- Before you use each bottle for the first time, you must prime it. Remove the clear plastic cover and the blue plastic safety clip. Hold the bottle at arm's length away from you. Using your index and middle fingers on the top of the bottle and your thumb on the bottom of the bottle, press down evenly and release the pump 5 times. The bottle is now ready to use.
- To use this nose spray, gently blow your nose. Sit up straight or stand and tilt your head forward slightly. Place the tip of the spray container into the nose. Be sure to point the container away from the center of your nose. Breathe gently through the nostril and squeeze the spray container. If your dose requires 2 sprays, repeat the process for your other nostril. Replace the clear plastic cover after each use.
- Do NOT use Prodent Forte 20 spray for more than 5 days. Prodent Forte 20 spray is not for the treatment of mild to moderate or chronic pain (eg, headache).
- Avoid contact with the eyes. If you get Prodent Forte 20 spray in your eyes, rinse it out with water. If eye irritation persists for more than 1 hour, contact your doctor.
- Each bottle contains 1 day's supply of Prodent Forte 20 spray. Discard each bottle within 24 hours of opening it, even if it still contains some unused medicine.
- If you miss a dose of Prodent Forte 20 spray and you are taking it regularly, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Prodent Forte 20 spray.
Uses of Prodent Forte 20 in details
Use: Labeled Indications
Pain, moderate to moderately severe: Short-term (up to 5 days) management of moderate to moderately severe pain in adults that requires analgesia at the opioid level.
Off Label Uses
Migraine
Data from a prospective, randomized, double-blind, double-dummy, placebo and active comparator, crossover, non-inferiority trial suggests that intranasal Prodent Forte 20 may be beneficial for acute abortive treatment of migraine in patients with a history of episodic migraines for at least 1 year.
Prodent Forte 20 description
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Prodent Forte 20 is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Prodent Forte 20 dosage
Carefully consider the potential benefits and risks of Prodent Forte 20 tromethamine tablets and other treatment options before deciding to use Prodent Forte 20 tromethamine tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals. In adults, the combined duration of use of IV or IM dosing of Prodent Forte 20 tromethamine and Prodent Forte 20 tromethamine tablets is not to exceed 5 days. In adults, the use of Prodent Forte 20 tromethamine tablets is only indicated as continuation therapy to IV or IM dosing of Prodent Forte 20 tromethamine.
Transition from IV or IM dosing of Prodent Forte 20 tromethamine (single- or multiple-dose) to multiple-dose Prodent Forte 20 tromethamine tablets:
Patients age 17 to 64: 20 mg PO once followed by 10 mg q4 to 6 hours prn not > 40 mg/day
Patients age ≥ 65, renally impaired, and/or weight < 50 kg (110 lbs): 10 mg PO once followed by 10 mg q4 to 6 hours prn not > 40 mg/day
Note:
Oral formulation should not be given as an initial dose.
Use minimum effective dose for the individual patient.
Do not shorten dosing interval of 4 to 6 hours.
Total duration of treatment in adult patients: the combined duration of use of IV or IM dosing of Prodent Forte 20 tromethamine and Prodent Forte 20 tromethamine tablets is not to exceed 5 days.
The following table summarizes Prodent Forte 20 tromethamine tablet dosing instructions in terms of age group:
| Patient Population | Prodent Forte 20 Tromethamine Tablets (following IV or IM dosing of Prodent Forte 20 tromethamine) |
| Age < 17 years | Oral not approved |
| Adult Age 17 to 64 years | 20 mg once, then 10 mg q4 to 6 hours prn not > 40 mg/day |
| Adult Age ≥ 65 years, renally impaired, and/or weight < 50 kg | 10 mg once, then 10 mg q4 to 6 hours prn not > 40 mg/day |
Prodent Forte 20 interactions
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What other drugs will affect Prodent Forte 20?
Prodent Forte 20 slightly reduces the plasma protein-binding of warfarin. In vitro studies indicate that at therapeutic concentration of salicylate, the binding of Prodent Forte 20 reduces from approximately 99.2-97.5%; representing a potential 2-fold increase in unbound plasma Prodent Forte 20 levels. Prodent Forte 20 has been reported to reduce the diuretic response to furosemide in normovolemic individuals by approximately 20%.
Concomitant administration of Prodent Forte 20 and probenecid results in decreased clearance of Prodent Forte 20 and significant increase in Prodent Forte 20 plasma levels (approximately 3-fold increase), and there is an increase of approximately 2-fold in terminal half-life.
Increase in plasma lithium concentration due to inhibition of renal lithium clearance has been reported with some NSAIDs. There have been some reports of increased lithium plasma levels with Prodent Forte 20 also.
There have been reports of a possible interaction of Prodent Forte 20 and nondepolarizing muscle relaxants, which lead to apnea. Concomitant use of Prodent Forte 20 and angiotensin-converting enzyme inhibitors may increase the risk of renal impairment, particularly in volume-depleted patients.
Very few cases of seizure have been reported with concomitant use of Prodent Forte 20 and antiepileptic drugs (phenytoin, carbamazepine). There have been reports of hallucinations when Prodent Forte 20 is concomitantly used with psychoactive drugs (fluoxetine, thiothixene, alprazolam).
Laboratory Tests: Prodent Forte 20 inhibits platelet aggregation and may prolong bleeding time.
Food: Food reduces the rate but not the extent of absorption.
Prodent Forte 20 side effects
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What are the possible side effects of Prodent Forte 20?
Applies to Prodent Forte 20 ophthalmic: ophthalmic solution
In addition to its needed effects, some unwanted effects may be caused by Prodent Forte 20 ophthalmic. In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Prodent Forte 20 ophthalmic:
More common:
- Itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
- redness of the clear part of the eye
- sensitivity to light
- swelling of the eye
- tearing
- throbbing pain
- Blurred vision or other change in vision
- eye irritation or redness
Minor Side Effects
Some of the side effects that can occur with Prodent Forte 20 ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Stinging or burning of the eye when medicine is applied
- Dry eyes
- headache
Prodent Forte 20 contraindications
See also:
What is the most important information I should know about Prodent Forte 20?
Prodent Forte 20 Tromethamine is contraindicated in patients with previously demonstrated hypersensitivity to Prodent Forte 20 Tromethamine.
Prodent Forte 20 Tromethamine is contraindicated in patients with active peptic ulcer disease, in patients with recent gastrointestinal bleeding or perforation and in patients with a history of peptic ulcer disease or gastrointestinal bleeding.
Prodent Forte 20 Tromethamine should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Prodent Forte 20 Tromethamine is contraindicated as prophylactic analgesic before any major surgery.
Prodent Forte 20 Tromethamine is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
Prodent Forte 20 Tromethamine is contraindicated in patients with advanced renal impairment or in patients at risk for renal failure due to volume depletion.
Prodent Forte 20 Tromethamine is contraindicated in labor and delivery because, through its prostaglandin synthesis inhibitory effect, it may adversely affect fetal circulation and inhibit uterine musculature, thus increasing the risk of uterine hemorrhage.
Prodent Forte 20 Tromethamine inhibits platelet function and is, therefore, contraindicated in patients with suspected or confirmed cerebrovascular bleeding, hemorrhagic diathesis, incomplete hemostasis and those at high risk of bleeding.
Prodent Forte 20 Tromethamine is contraindicated in patients currently receiving aspirin or NSAIDs because of the cumulative risks of inducing serious NSAID-related adverse events.
The concomitant use of Prodent Forte 20 Tromethamine and probenecid is contraindicated.
The concomitant use of Prodent Forte 20 Tromethamine and pentoxifylline is contraindicated.
Prodent Forte 20 Tromethamine injection is contraindicated for neuraxial (epidural or intrathecal) administration due to its alcohol content.
Active ingredient matches for Prodent Forte 20:
Ketorolac in Paraguay.
List of Prodent Forte 20 substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Prodent Forte (Paraguay) | |
| Quetorol (Peru) | |
| Rapix (Guatemala, Mexico) | |
| Capsule; Oral; Ketorolac Tromethamine 10 mg (Senosiain) | |
| Injectable; Injection; Ketorolac Tromethamine 15 mg / ml (Senosiain) | |
| Capsules; Oral; Ketorolac Tromethamine 10 mg (Senosiain) | |
| ratio-Ketorolac | |
| Solution; Ophthalmic; Ketorolac Tromethamine 0.5% | |
| Ratio-ketorolac solution 0.5 % (Ratiopharm Inc Division Of Teva Canada Limited (Canada)) | |
| Rativol (Indonesia) | |
| Rativol / amp 10 mg/1 mL x 1 mL x 5's (Sanbe) | |
| Rativol / amp 30 mg/1 mL x 1 mL x 5's (Sanbe) | $ 18.60 |
| Remopain (Indonesia, Philippines) | |
| Remopain 30 mg/1 mL x 1 mL x 5's (Dexa Medica) | $ 10.52 |
| Remopain 10 mg/1 mL x 5's (Dexa Medica) | $ 12.09 |
| Remopain 30 mg/1 mL x 5's (Dexa Medica) | $ 18.60 |
| Remopain inj 30 mg/mL 5's (Dexa Medica) | |
| Remopain inj 30 mg/mL 1 mL x 5 x 1's (Dexa Medica) | $ 10.56 |
| Rikedol (Italy) | |
| Rindopain (Indonesia) | |
| Rindopain 10 mg x 2 x 10's (Yarindo Farmatama) | $ 7.44 |
| Rindopain / amp 30 mg/1 mL x 5's (Yarindo Farmatama) | $ 8.68 |
| Rolac (Bangladesh, Indonesia) | |
| Rolac 200 mg x 1 Blister 10 Tablet (Actavis) | |
| Rolac 400 mg x 1 Blister 10 Tablet (Actavis) | |
| Rolac 30 mg/1 mL x 1 mL x 5's (Actavis) | $ 16.12 |
| ROLAC 0.50% EYE DROPS 1 packet / 5 ML eye drop each (Actavis) | $ 0.54 |
| Rolac 0.5% w/v Eye Drop (Actavis) | $ 0.54 |
| ROLAC (ALKEM) | |
| ROLAC 30MG INJECTION 1 vial / 1 ML injection each (Alkem Laboratories Ltd) | $ 0.08 |
| Rolacsin (Italy) | |
| Rolesen (Ecuador, Mexico, Peru) | |
| Rolodiquim (Mexico) | |
| Rometran-K (Mexico) | |
| Romilac (Bangladesh) | |
| Ropain (Indonesia) | |
| Rotek (Bangladesh) | |
| Rotoket (Philippines) | |
| Samulgin 0.5% (Egypt) | |
| Sanagese (Peru) | |
| Sanoket (Bangladesh) | |
| Sauran (Paraguay) | |
| Sauran Forte (Paraguay) | |
| Scelto (Indonesia) | |
| Scelto / amp 10 mg/1 mL x 5's (Pharos) | $ 13.39 |
| Scelto 30 mg/1 mL x 5's (Pharos) | $ 19.59 |
| Sebapain (Mexico) | |
| Sinalgico (Argentina) | |
| Sinalgico SL (Argentina) | |
| Sirolac (Taiwan) | |
| Sirolac 30 mg/1 mL x 1 mL | |
See 936 substitutes for Prodent Forte 20 | |
References
- PubChem. "ketorolac". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "ketorolac". http://www.drugbank.ca/drugs/DB00465 (accessed September 17, 2018).
- MeSH. "Cyclooxygenase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Prodent Forte 20 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Prodent Forte 20. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
