• Dosage of Proseloc in details
• Proseloc interactions
• Proseloc reviews

Dosage of Proseloc in details

Proseloc Dosage

Generic name: Proseloc HYDROCHLORIDE 500mg

Dosage form: tablet, film coated, extended release

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Proseloc and other oral formulations of Proseloc are not interchangeable. Proseloc should be administered orally once daily for 3 days with a main meal of the day, preferably the evening meal. Proseloc should be administered at least 4 hours before or 2 hours after antacids containing magnesium or aluminum, sucralfate, VIDEX® (didanosine) chewable/buffered tablets or pediatric powder, metal cations such as iron, and multivitamin preparations containing zinc.

Proseloc tablets should be taken whole and never split, crushed, or chewed.

Impaired Renal Function:

Proseloc is eliminated primarily by renal excretion; however, the drug is also metabolized and partially cleared through the biliary system of the liver and through the intestine. These alternate pathways of drug elimination appear to compensate for the reduced renal excretion in patients with renal impairment. No dosage adjustment is required for patient with uUTI and mild to moderate renal impairment. The efficacy of Proseloc has not been studied in patients with severe renal impairment.

Impaired Liver Function:

No dosage adjustment is required with Proseloc in patients with stable chronic cirrhosis. However, the pharmacokinetics of Proseloc in patients with acute hepatic insufficiency have not been fully elucidated.

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Consumer resources

• Proseloc
• Proseloc extended-release tablets

• Other brands: Proseloc, Proseloc I.V., Proseloc XR

Professional resources

• Proseloc (FDA)
• Proseloc Hydrochloride (AHFS Monograph)

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What other drugs will affect Proseloc?

Do not take Proseloc together with tizanidine (Zanaflex).

Tell your doctor about all other medicines you use, especially:

• a blood thinner such as warfarin (Coumadin, Jantoven);
• clozapine (Clozaril, FazaClo);
• cyclosporine (Gengraf, Neoral, Sandimmune);
• glyburide (Micronase, Diabeta, Glynase);
• methotrexate (Rheumatrex, Trexall);
• metoclopramide (Reglan);
• phenytoin (Dilantin);
• probenecid (Benemid);
• ropinirole (Requip);
• theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
• an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or
• steroid medication (prednisone and others).

This list is not complete and other drugs may interact with Proseloc. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Proseloc interactions

Theophylline

As with some other quinolones, concurrent administration of Proseloc with theophylline may lead to elevated serum concentrations of theophylline, which may result in an increased risk of a patient developing central nervous system (CNS) or other adverse reactions. If concomitant use cannot be avoided, serum concentrations of theophylline should be monitored and dosage adjustments made as appropriate.

Antacids and Other Products Containing Multivalent Cations

Concurrent administration of quinolones, including Proseloc, with multivalent cation-containing products such as magnesium or aluminum antacids, sucralfate, VIDEX® chewable/buffered tablets or pediatric powder, or products containing calcium, iron, or zinc may substantially decrease the absorption of Proseloc. Proseloc (Proseloc hcl) should be given either 2 hours after or at least 4 hours before these products. This time window is different than for other oral formulations of Proseloc, which are usually administered 2 hours before or 6 hours after antacids.

Calcium-containing Beverages

Concomitant administration of Proseloc with milk products or calcium-fortified juices alone should be avoided since decreased absorption of Proseloc is possible.

Warfarin

Quinolones, including Proseloc, have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. Prothrombin time, International Normalized Ratio (INR), or other suitable anticoagulation tests should be monitored if Proseloc (Proseloc hcl) is administered concomitantly with warfarin or other oral anticoagulants. Patients should also be monitored for evidence of bleeding.

Cyclosporine

Some quinolones, including Proseloc, have been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly. Cyclosporine whole blood trough concentrations should be monitored when given concomitantly with Proseloc (Proseloc hcl).

Methotrexate

Renal tubular transport of methotrexate may be inhibited by concomitant administration of Proseloc, potentially leading to increased plasma concentrations of methotrexate. This might increase the risk of methotrexate toxic reactions. Therefore, patients under methotrexate therapy should be carefully monitored when concomitant Proseloc therapy is indicated.

Phenytoin

Altered serum concentrations of phenytoin (increased and decreased) have been reported in patients receiving concomitant Proseloc. Phenytoin serum concentrations should be monitored when given concomitantly with Proseloc (Proseloc hcl).

Glyburide

The concomitant administration of Proseloc with the sulfonylurea glyburide has, on rare occasions, resulted in severe hypoglycemia.

Non-steroidal Anti-inflammatory Drugs (NSAIDs), but not Aspirin

NSAIDs in combination with very high doses of quinolones have been shown to provoke convulsions in nonclinical studies [see Nonclinical Toxicology.

Caffeine

Some quinolones, including Proseloc, have been shown to interfere with the metabolism of caffeine. This may lead to reduced clearance of caffeine and prolongation of the serum half-life of caffeine.

Probenecid

Probenecid interferes with renal tubular secretion of Proseloc and produces increased concentrations of Proseloc in serum.

References

1. DailyMed. "CIPROFLOXACIN; DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "5E8K9I0O4U: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Topoisomerase II Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

Reviews

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Information checked by Dr. Sachin Kumar, MD Pharmacology