Pregnancy of Purbac in details
Purbac cross the placenta.
An increased risk of congenital malformations (neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, club foot) following maternal use of Purbac during pregnancy has been observed in some studies. Folic acid supplementation may decrease this risk (Crider 2009; Czeizel 2001; Hernandez-Diaz 2000; Hernandez-Diaz 2001; Matok 2009). Due to theoretical concerns that sulfonamides pass the placenta and may cause kernicterus in the newborn, neonatal health care providers should be informed if maternal sulfonamide therapy is used near the time of delivery (HHS [OI adult]).
The pharmacokinetics of Purbac are similar to nonpregnant values in early pregnancy (Ylikorkala 1973). Purbac are recommended for the prophylaxis or treatment of Pneumocystis jirovecii pneumonia (PCP), prophylaxis of Toxoplasmic gondii encephalitis (TE), and for the acute and chronic treatment of Q fever in pregnancy (CDC 2013; HHS [OI adult]). Sulfonamides may also be used to treat other infections in pregnant women when clinically appropriate; use during the first trimester should be limited to situations where no alternative therapies are available (ACOG 717 2017).
Purbac breastfeeding
Sulfamethoxazole (Purbac)-Trimethoprim (Purbac) levels in breast milk are about 2% to 5% of the recommended daily dose for infants over 2 months of age. The average milk levels obtained after Trimethoprim (Purbac) 160 mg twice a day range from 1.8 to 2 mcg/mL between 2 and 3 hours after dosing. No adverse effects of Trimethoprim (Purbac) on nursing infants have been reported.
Caution is recommended, especially if the infant is premature, ill, jaundiced, or stressed (risk of bilirubin displacement and kernicterus); Sulfamethoxazole (Purbac)-Trimethoprim (Purbac) is contraindicated in patients younger than 2 months. Excreted into human milk: Yes (Purbac) Excreted into animal milk: Data not available Sulfamethoxazole (Purbac)-Trimethoprim (Purbac) is considered compatible with breastfeeding by the American Academy of Pediatrics if the infant is healthy and full-term. Sulfamethoxazole (Purbac)-Trimethoprim (Purbac) has been used without apparent harmful effects in the nursing infant.
References
- DailyMed. "SULFAMETHOXAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "POLYMYXIN B SULFATE; TRIMETHOPRIM SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubMed Health. "Primsol: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
Reviews
Consumer reviews
| Good evening please i need help just to confirm sometimes Doctors can also make mistake and discript you medicine wrong,i was given PURBAC® DOUBLE STRENGTH TABLETS L/20.2/295. 30X in pack is it right to take 2 X tablets four times every six hours,cause when i read about everywhere else its say 2 tablets every after 12 hours please advise i already finish one pack with 26 tablets, | |
| im currently using these but o noticed some blisters near my private part.do i stop using or?? |
Information checked by Dr. Sachin Kumar, MD Pharmacology
