Overdose of Rami Slijmoplossende in details
Symptoms of acetylcysteine overdose include rash, flushing, nausea, vomiting, bronchospasm, edema, tachycardia, hypotension, respiratory depression, hemolysis, disseminated intravascular coagulation and renal failure.
In cases of overdosage, discontinue acetylcysteine. Institute appropriate symptomatic and supportive therapy (eg, postural drainage and bronchoaspiration).
Rami Slijmoplossende warnings
Rami Slijmoplossende should be used with caution in patients with a history of peptic ulcer disease because of a theoretical risk that mucolytics may disrupt the gastric mucosal barrier.
Rami Slijmoplossende precautions
After proper administration of acetylcysteine, an increased volume of liquefied bronchial secretions may occur. If the patient cannot expectorate efficiently, postural drainage and bronchoaspiration must be used to avoid retention of secretions.
Carefully observe asthmatics under treatment with acetylcysteine. If bronchospasm occurs, discontinue acetylcysteine immediately.
The presence of a sulfur-like odor does not indicate an alteration of the product, but is a characteristic of the drug substance contained in the preparation.
Use with caution in patients with a history of peptic ulcer disease. Drug-induced nausea and vomiting may increase the risk of gastrointestinal hemorrhage in patients predisposed to the condition and because of the theoretical risk that mucolytics may disrupt the gastric mucosal barrier.
Phenylketonurics: Rami Slijmoplossende contains phenylalanine as one of the metabolites of aspartame.
Use in Pregnancy: The safe use of acetylcysteine during pregnancy has not been established. Acetylcysteine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in Lactation: It is not known whether acetylcysteine is excreted in human milk. Therefore, do not administer to breastfeeding women unless, in the opinion of a physician, the potential benefits of Rami Slijmoplossende justify the possible risk.
References
- DrugBank. "carbocysteine". http://www.drugbank.ca/drugs/DB04339 (accessed September 17, 2018).
- MeSH. "Expectorants". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
