What is Rexidin PLUS?
Rexidin PLUS is a germicidal mouthwash that reduces bacteria in the mouth.
Rexidin PLUS oral rinse is used to treat gingivitis (swelling, redness, bleeding gums). Rexidin PLUS is usually prescribed by a dentist.
Rexidin PLUS oral rinse is not for treating all types of gingivitis. Use the medication only to treat the condition your dentist prescribed it for. Do not share this medication with another person, even if they have the same gum symptoms you have.
Rexidin PLUS may also be used for purposes not listed in this medication guide.
Rexidin PLUS indications
Rexidin PLUS® (Rexidin PLUS
Oral Rinse USP, 0.12%) is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. Rexidin PLUS® has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.
How should I use Rexidin PLUS?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Rinse your mouth with Rexidin PLUS twice daily after brushing your teeth.
Measure your dose using the cup provided with the medication. Swish the medicine in your mouth for at least 30 seconds, then spit it out. Do not swallow the mouthwash.
Do not add water to the oral rinse. Do not rinse your mouth with water or other mouthwashes right after using Rexidin PLUS.
Rexidin PLUS may leave an unpleasant taste in your mouth. Do not rinse your mouth to remove this taste after using the medication. You may rinse the medicine away and reduce its effectiveness.
Use this medication for the full prescribed length of time. Your symptoms may improve before your gingivitis is completely cleared. Rexidin PLUS will not treat a viral or fungal infection such as cold sores, canker sores, or oral thrush (yeast infection).
Visit your dentist at least every 6 months for preventive tooth and gum care.
Store Rexidin PLUS at room temperature away from moisture and heat.
Uses of Rexidin PLUS in details
Use: Labeled Indications
Gingivitis:
Oral rinse: Antimicrobial dental rinse for gingivitis treatment
Periodontitis: Periodontal chip: Adjunctive therapy to scaling and root planning procedures to reduce pocket depth in patients with periodontitis
Off Label Uses
Medication-related osteonecrosis of the jaw (MRONJ), adjunctive therapy:
Oral rinse:
Based on a position paper by the American Association of Maxillofacial Surgeons (AAOMS), Rexidin PLUS oral rinse is an effective and recommended adjunctive treatment strategy in the management of medication-related osteonecrosis of the jaw (MRONJ) (stage 1 and above [eg, patients with exposed and necrotic bone or fistulae that probes to bone]).
Oropharyngeal decontamination to reduce the risk of ventilator-associated or hospital-acquired pneumonia, Cardiac surgical patients:
Oral rinse:
Data from a prospective, randomized, double-blind, placebo-control trial and a prospective, randomized, case-controlled trial in patients undergoing coronary artery bypass grafting, valve, or other open heart surgical procedures who received Rexidin PLUS 0.12% oral rinse during the perioperative period showed a decreased rate in hospital-acquired pneumonia. However, the trials used in both meta-analyses were heterogeneous and included patients in a variety of settings (eg, cardiothoracic, general ICU, mixed medical-surgical ICU, trauma ICU). The trials also displayed significant variability with Rexidin PLUS treatment regimens. Rexidin PLUS concentration varied from 0.12%, 0.2%, or 2% across studies. Frequency of administration, Rexidin PLUS dosage form (oral rinse, gel, paste, foam), and technique of application also varied across studies. In the US, Rexidin PLUS for use in the oral cavity is commercially available only as 0.12% solution. Additional trials may be necessary to further define the role of Rexidin PLUS oral rinse in this condition.
Rexidin PLUS description
Each chip contains chlorhexidine gluconate 2.5 mg in a biodegradable matrix of hydrolyzed gelatin (cross-linked with glutaraldehyde).
Rexidin PLUS also contains glycerin and purified water as excipients.
Rexidin PLUS, an antimicrobial agent, is 1, 1'-hexamethylenebis [5-(p-chlorophenyl)biguanide] di-D-gluconate. Molecular Formula: C22H30Cl2N10·2C6H12O7. Molecular Weight: 897.8.
Rexidin PLUS dosage
Rexidin PLUS Dosage
Generic name: Rexidin PLUS 1.2mg in 1mL
Dosage form: mouthwash
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Rexidin PLUS therapy should be initiated directly following a dental prophylaxis. Patients using Rexidin PLUS should be reevaluated and given a thorough prophylaxis at intervals no longer than six months. Recommended use is twice daily oral rinsing for 30 seconds, morning and evening after toothbrushing. Usual dosage is 15ml (marked in cap) of undiluted Rexidin PLUS. Patients should be instructed to not rinse with water or other mouthwashes, brush teeth or eat immediately after using Rexidin PLUS. Rexidin PLUS is not intended for ingestion and should be expectorated after rinsing.
More about Rexidin PLUS (Rexidin PLUS topical)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Support Group
- Pricing & Coupons
- En Espanol
- 2 Reviews - Add your own review/rating
- Generic Availability
Consumer resources
- Rexidin PLUS solution
- Rexidin PLUS oral rinse
- Rexidin PLUS (Advanced Reading)
- Other brands: Hibiclens, Betasept, Rexidin PLUS, ChloraPrep One-Step, More (9) »
Professional resources
- Rexidin PLUS (FDA)
- Rexidin PLUS topical (AHFS Monograph)
Related treatment guides
- Gingivitis
- Mucositis
- Periodontitis
Rexidin PLUS interactions
See also:
What other drugs will affect Rexidin PLUS?
Rexidin PLUS is incompatible with the soap, and detergents containing anionic group (saponins, sodium lauryl sulfate, sodium carboxymethyl cellulose).
Rexidin PLUS Pharmaniaga is compatible with any medication containing cationic group (cetrimonium bromide, benzalkonium chloride).
Rexidin PLUS side effects
See also:
What are the possible side effects of Rexidin PLUS?
The most common side effects associated with Rexidin PLUS oral rinses are (1) an increase in staining of teeth and other oral surfaces, (2) an increase in calculus formation; and (3) an alteration in taste perception; see WARNINGS and PRECAUTIONS.
Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with the use of Rexidin PLUS rinse.
The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum. Each occurred at a frequency of less than 1.0%.
Among post marketing reports, the most frequently reported oral mucosal symptoms associated with Rexidin PLUS oral rinse are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia.
Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using Rexidin PLUS oral rinse.
There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using Rexidin PLUS oral rinse.
Rexidin PLUS contraindications
See also:
What is the most important information I should know about Rexidin PLUS?
You should not use this medication if you are allergic to Rexidin PLUS.
If you have periodontal disease, you may need special treatments while you are using Rexidin PLUS.
Rexidin PLUS oral rinse is not for treating all types of gingivitis. Use the medication only to treat the condition your dentist prescribed it for. Do not share this medication with another person, even if they have the same gum symptoms you have.
Do not give this medication to a child or teenager without a doctor's advice.
Do not add water to Rexidin PLUS oral rinse. Do not rinse your mouth with water or other mouthwashes right after using Rexidin PLUS.
Avoid eating, drinking, or brushing your teeth just after using this medication.
Do not use any other mouthwash unless your doctor has told you to.
Rexidin PLUS can stain teeth, dentures, tooth restorations, your tongue, or the inside of your mouth. Talk with your dentist about ways to remove staining from these surfaces. Stains may be harder to remove from false teeth that have scratches in their surfaces.
Visit your dentist at least every 6 months for preventive tooth and gum care.
Active ingredient matches for Rexidin PLUS:
Chlorhexidine gluconate in India.
| Unit description / dosage (Manufacturer) | Price, USD |
| 150ml | $ 0.83 |
List of Rexidin PLUS substitutes (brand and generic names): | |
| Rexidin | |
| Rexidin 0.2% w/v M-WASH / 100ml | $ 0.52 |
| Rexidin 0.2% w/v M-WASH / 1l | $ 2.88 |
| Rexidin 0.2% w/v M-WASH / 50ml | $ 0.28 |
| 0.2 % w/v x 100ml | $ 0.52 |
| 0.2 % w/v x 1l | $ 2.88 |
| 0.2 % w/v x 50ml | $ 0.28 |
| REXIDIN 0.2% MOUTH WASH 1 bottle / 120 ML mouth wash each (Indoco Remedies Ltd) | $ 0.89 |
| REXIDIN 0.2% MOUTH WASH 1 bottle / 170 ML mouth wash each (Indoco Remedies Ltd) | $ 0.87 |
| REXIDIN 0.2% MOUTH WASH 1 bottle / 50 ML mouth wash each (Indoco Remedies Ltd) | $ 0.78 |
| REXIDIN 0.25% GEL 1 tube / 20 GM gel each (Indoco Remedies Ltd) | $ 0.08 |
| Rexidin 0.2% Mouth Wash (Indoco Remedies Ltd) | $ 0.94 |
| Rexidin 0.25% Gel (Indoco Remedies Ltd) | $ 0.08 |
| RINZIN (MEDMANOR) | |
| RINZIN / MEDMANOR 0.20% MOUTH WASH 1 bottle / 100 ML mouth wash each (Med Manor Organics Pvt Ltd) | $ 0.56 |
| Rouhex-g (Canada) | |
| Savlorin | |
| Scrub Care | |
| Scrub Care solution 4 mg/100mL (Productos Urologos De Mexico, S.A. De C.V. (US)) | |
| SEPTLON | |
| SEPTLON SCRUB 1 packet / 100 ML scrub each (West-Coast Pharmaceutical Works Ltd) | $ 1.20 |
| Septofervex (Poland) | |
| Sicura 3 (Italy) | |
| SILKIN SOAP (India) | |
| 75g (Haledew) | $ 0.48 |
| Silkin Soap Chlorhexidine gluconate 1.5 %w/w, Aloe vera 1 % w/w, Glycerin 2 % w/w. SOAP / 75g (Haledew) | $ 0.48 |
| SILKIN SOAP soap 75g (Haledew) | $ 0.48 |
| Silkin Soap Chlorhexidine gluconate 1.5 %w/w, Aloe vera 1 % w/w, Glycerin 2 % w/w. SOAP / 75g (Haledew) | $ 0.48 |
| SKINN C | |
| Spectrum-4 | |
| STARLON | |
| STARLON SOLUTION 1 bottle / 100 ML solution each (Cadila Pharmaceuticals Ltd) | $ 0.37 |
| Superdent Chlorhexidine Gluconate Oral Rinse | |
| Superdent Chlorhexidine Gluconate Oral Rinse liquid .12 g/100mL (Darby Dental Supply, LLC (US)) | |
| SUTHOL | |
| SUTHOL ANTISEPTIC SPRAY 1 packet / 100 ML spray each (G D Pharmaceuticals Pvt Ltd) | $ 0.72 |
| SYMODENT M-WASH (India) | |
| 0.2 % w/v x 100ml (Symbiosis) | $ 0.46 |
| Symodent M-Wash 0.2% w/v M-WASH / 100ml (Symbiosis) | $ 0.46 |
| SYMODENT M-WASH mouthwash 0.2 % w/v x 100ml (Symbiosis) | $ 0.46 |
| Symodent M-Wash 0.2% w/v M-WASH / 100ml (Symbiosis) | $ 0.46 |
| Trihexid (Singapore) | |
| Trihexid 0.2 % x 200 mL x 1's | |
| TROGYL-DENTA (India) | |
| 1 % w/w x 15g (JB Chemicals) | $ 0.30 |
| TROGYL-DENTA dental gel 1 % w/w x 15g (JB Chemicals) | $ 0.30 |
| Welwash | |
| Welwash 0.002% w/v Mouth Wash (Fitwel Pharmaceuticals Private Limited) | $ 1.14 |
| WONDENT MOUTH WASH (India) | |
| WONDENT MOUTH WASH mouthwash 0.2 % w/v x 100ml (Wonder (Wonder HC)) | $ 0.48 |
| WYDENT MOUTH WASH (India) | |
| WYDENT MOUTH WASH mouthwash 150ml (CE-Biotec) | $ 0.95 |
| Xtragene 2/Xtragene 4 (Indonesia) | |
| Zak Mouthwash Mint | |
| Zak Mouthwash Strawberry | |
See 284 substitutes for Rexidin PLUS | |
References
- DailyMed. "CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "chlorhexidine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "chlorhexidine". http://www.drugbank.ca/drugs/DB00878 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Rexidin PLUS are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Rexidin PLUS. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported useful
Was the Rexidin PLUS drug useful in terms of decreasing the symptom or the disease?According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
| Users | % | ||
|---|---|---|---|
| Useful | 1 | 100.0% | |
Consumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yet1 consumer reported age
| Users | % | ||
|---|---|---|---|
| > 60 | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
