Actions of Rhinathiol 5% Expectorant Carbocistéine in details
Rhinathiol 5% Expectorant Carbocistéine, a derivative of acetylcysteine, is a mucoregulating agent. Its major action is thought to be on the metabolism of mucus-producing cells. The mucus produced under the influence of Rhinathiol 5% Expectorant Carbocistéine has an increased content of the less viscous sialomucin and a reduced content of the highly viscous fucomucin. Sialomucins influence the rheological properties of mucus and may also, through the inhibition of kinins, reduce or prevent bronchial inflammation and bronchospasm.
Rhinathiol 5% Expectorant Carbocistéine is rapidly and well-absorbed after oral administration. Following oral administration of 1.5 g Rhinathiol 5% Expectorant Carbocistéine, peak serum concentration of 13-16 mg/L was reached in 1-2 hrs. Plasma t½ was 1.5-2 hrs. Rhinathiol 5% Expectorant Carbocistéine penetrates well into lung tissues and respiratory mucus suggesting local action. Rhinathiol 5% Expectorant Carbocistéine undergoes acetylation, decarboxylation and sulfoxidation. Majority of Rhinathiol 5% Expectorant Carbocistéine is excreted unchanged in the urine.
Rhinathiol 5% Expectorant Carbocistéine administration
Should be taken with food.
Rhinathiol 5% Expectorant Carbocistéine pharmacology
Rhinathiol 5% Expectorant Carbocistéine enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
