Rythma Pregnancy

• Pregnancy of Rythma in details
• Rythma breastfeeding
• Rythma reviews

Pregnancy of Rythma in details

Rythma and the active metabolite, N-desethylamiodarone, cross the placenta (Plomp 1992).

In utero exposure may cause fetal harm. Reported risks include neonatal bradycardia, QT prolongation, and periodic ventricular extrasystoles; neonatal hypothyroidism (with or without goiter); neonatal hyperthyroxinemia; neurodevelopmental abnormalities independent of thyroid function; jerk nystagmus with synchronous head titubation; fetal growth retardation; and/or premature birth.

Oral or IV Rythma should be used in pregnancy only to treat arrhythmias refractory to other treatments or when other treatments are contraindicated (ACC/AHA/HRS [Page 2015]).

Rythma (administered either maternally or directly to the fetus) may be considered for the in utero management of fetal atrial flutter and in life-threatening cases of sustained fetal supraventricular tachycardia refractory to first and second line agents, but because of potential toxicity, risks and benefits should be assessed (AHA [Donofrio 2014]; Kang 2015).

If in utero exposure occurs, newborns should be monitored for thyroid disorders and cardiac arrhythmias.

Rythma breastfeeding

Some authorities believe this drug can be used during breastfeeding with periodic monitoring of infant cardiac and thyroid function, especially if only one dose is administered.

Use is considered contraindicated and should not be used during breastfeeding. Excreted into human milk: Yes

See references

References for pregnancy information

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Cordarone

   Intravenous (Rythma)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

4. "Product Information. Cordarone (Rythma)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

References for breastfeeding information

1. "Product Information. Cordarone

   Intravenous (Rythma)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

2. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
3. "Product Information. Cordarone (Rythma)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
4. Cerner Multum, Inc. "Australian Product Information." O 0
5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

References

1. PubMed Health. "Pacerone: This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
2. Human Metabolome Database (HMDB). "Amiodarone: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology