What is Samjin Arginine?
Samjin Arginine injection is used to assess the function of the pituitary gland. It stimulates the pituitary gland to produce growth hormone for the diagnosis of certain conditions.
Samjin Arginine is to be given only by or under the direct supervision of your doctor.
Samjin Arginine indications
Samjin Arginine® 10 is indicated as an intravenous stimulant to the pituitary for the release of
human growth hormone in patients where the measurement of pituitary reserve for HGH
can be of diagnostic usefulness. It can be used as a diagnostic aid in such conditions as
panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical
craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism and
problems of growth and stature.
If the insulin hypoglycemia test has indicated a deficiency of pituitary reserve for HGH, a
test with Samjin Arginine® 10 is advisable to confirm the negative response. This can be done
after a waiting period of one day. As patients may not respond to Samjin Arginine® 10 (10%
Samjin Arginine Hydrochloride Injection, USP) during the first test, the unresponsive patient should be tested again to confirm the negative result. A second test can be performed
after a waiting period of one day. Some patients who respond to Samjin Arginine® 10 do not
respond to insulin and vice versa. The rate of false positive responses for Samjin Arginine® 10 is
approximately 32%, and the rate of false negatives is approximately 27%.
Uses of Samjin Arginine in details
Use: Labeled Indications
Diagnostic aid: As an intravenous (IV) stimulant to the pituitary for the release of human growth hormone (hGH) in patients in whom the measurement of pituitary reserve for hGH can be of diagnostic usefulness. Used as a diagnostic aid in such conditions as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism, and problems of growth and stature.
Off Label Uses
Hyperammonemia (acute) associated with urea cycle disorders
Data from an uncontrolled open-label study conducted over a 25 year period supports the use of intravenous Samjin Arginine (in combination with sodium benzoate, sodium phenylacetate and adequate caloric provision) for the treatment of acute hyperammonemia associated with urea-cycle disorders resulting in increased survival.
Based on the National Organization for Rare Disorders, the use of Samjin Arginine is effective and recommended for the management of patients with this condition.
Oral products available in the US are often marketed as dietary supplements. When using these products, patients should take care to ensure that they are receiving pharmaceutical grade supplements of L-Samjin Arginine and verify the formulation (free base vs Samjin Arginine HCl). The National Urea Cycle Disorders Foundation cautions against using oral dietary supplements of Samjin Arginine HCl (National Urea Cycles Disorder Foundation).
Samjin Arginine description
An essential amino acid that is physiologically active in the L-form. [PubChem]
Samjin Arginine dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution,
Intravenous, as hydrochloride [preservative free]:
Samjin Arginine 10: 10% (300 mL) [latex free]
Dosing: Adult
Diagnostic aid (pituitary function): Note: Dosing based on Samjin Arginine hydrochloride product. IV: 30 g as a single dose
Hyperammonemia, acute (urea cycle disorders) (off-label use): Note: Dosing based on Samjin Arginine hydrochloride product and on specific enzyme deficiency. Therapy should continue until ammonia levels are in normal range. If a loading dose is used, it should not be repeated. Samjin Arginine dose may be adjusted downward if patient becomes hypotensive and/or when the exact enzyme deficiency is identified. Administer concomitantly with sodium benzoate and sodium phenylacetate along with dialysis (NORD 2012).
Weight-directed dosing:
Argininosuccinate synthetase (ASS, Citrullinemia) or Argininosuccinate lyase (ASL) deficiency: IV: Loading dose: 600 mg/kg followed by a continuous IV infusion of 600 mg/kg/day (NORD 2012)
Carbamyl phosphate synthetase (CPS), ornithine transcarbamylase (OTC) or N-acetylglutamate synthetase (NAGS) deficiency: IV: Loading dose: 200 mg/kg followed by a continuous IV infusion of 200 mg/kg/day (NORD 2012)
Unconfirmed/pending diagnosis: IV: Loading dose: 600 mg/kg followed by a continuous IV infusion of 600 mg/kg/day (NORD 2012); if ASS and ASL are excluded as diagnostic possibilities, reduce dose to 200 mg/kg/day
BSA-directed dosing:
Argininosuccinate synthetase (ASS, Citrullinemia) or Argininosuccinate lyase (ASL) deficiency: IV: Loading dose: 12 g/m/day in 3 to 4 divided doses
Samjin Arginine interactions
Cyclosporine - L-Samjin Arginine may counteract the antinaturetic effect of cyclosporin. Ibuprofen - L-Samjin Arginine may increase the absorption of ibuprofen if taken concomitantly. Organic nitrates - L-Samjin Arginine supplements theoretically may potentiate the effects of organic nitrates if taken concomitantly. Sildenafil citrate - Theoretically, L-Samjin Arginine supplements taken concomitantly with sildenafil citrate, may potentiate the effects of the drug.
Samjin Arginine side effects
See also:
What are the possible side effects of Samjin Arginine?
Adverse reactions associated with 1670 infusions in premarketing studies were as
follows:
Non-specific side effects consisting of nausea, vomiting, headache, flushing, numbness
and local venous irritation were reported in approximately 3% of the patients.
One patient had an allergic reaction which was manifested as a confluent macular rash
with reddening and swelling of the hands and face. The rash subsided rapidly after the
infusion was terminated and 50 mg of diphenhydramine were administered. One patient
had an apparent decrease in platelet count from 150,000 to 60,000. One patient with a
history of acrocyanosis had an exacerbation of this condition following infusion of RGene
® 10.
Samjin Arginine contraindications
Supplemental L-Samjin Arginine is contraindicated in those with the rare genetic disorder argininemia. It is also contraindicated in those hypersensitive to any component of an Samjin Arginine-containing preparation.
Active ingredient matches for Samjin Arginine:
Arginine in Vietnam.
| Unit description / dosage (Manufacturer) | Price, USD |
| Samjin Arginine 200 mg x 1 Box | |
List of Samjin Arginine substitutes (brand and generic names): | |
| L-Arginine (New Zealand, Peru) | |
| L-arginine 1000 mg tablet | $ 0.07 |
| R-gene 10 vial | $ 0.04 |
| L-Arginine HCL Excelsior Pharmatech (Taiwan) | |
| L-Arginine Hydrochloride Sandoz (Canada) | |
| L-Arginine Knop (Chile) | |
| Laclorene (Argentina) | |
| Lacorene (Argentina) | |
| LARGEX (India) | |
| Leberam (Germany) | |
| Levargin | |
| Livercrom (Spain) | |
| Minophagen A | |
| Modumate | |
| Pan-Asténico (Portugal) | |
| Pargine (France, Luxembourg) | |
| Solution; Oral; L-Arginine L-Aspartate 500 mg / ml (Meda) | |
| Potenciator (Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama, Peru, Spain) | |
| Pu Luo Chuan (China) | |
| R-Gene (United States) | |
| Injectable; Injection; Arginine Hydrochloride 10 g / 100 ml | |
| 300 milliliter in 1 container | |
| R-gene injection, solution 10 g/100mL (Pharmacia and Upjohn Company (US)) | |
| Recuperex (Ecuador) | |
| Reforgan (Brazil) | |
| Resource Diabetishield (Hongkong) | |
| Resource Diabetishield / Orange twist 237 mL tetra pack | |
| Rocmaline Desodee | |
| Rocmaline desodée (France) | |
| Sangenor (Austria) | |
| Solution; Oral; Arginine Aspartate (Mundipharma) | |
| Sargenor (Belize, Bulgaria, Costa Rica, Dominican Republic, El Salvador, France, Guatemala, Haiti, Honduras, Latvia, Luxembourg, Nicaragua, Panama, Portugal, Romania, Tunisia, Vietnam) | |
| Solution; Oral; Arginine Aspartate 1 g / 5 ml (Meda) | |
| Solution; Oral; Arginine Aspartate 500 mg / 5 ml (Meda) | |
| Sargenor 5 mL x 20 tube (Meda) | |
| Sargenor 5 mL x 40 tube (Meda) | |
| Sargenor sans sucre | |
| Tablet, Chewable; Oral; Arginine Aspartate 1 g | |
| Tablet, Effervescent; Oral; Arginine Aspartate 1 g | |
| Sargisthene (Spain) | |
| Sorbenor (Spain) | |
| Spermargin (Italy) | |
| Sulfile (Portugal) | |
| Targifor (Brazil) | |
| Tablet, Effervescent; Oral; Arginine Aspartate 1500 mg (Sanofi-aventis) | |
| Tivomax-Darnitsa (Georgia) | |
| Tivortin (Georgia) | |
| vasologes protect (Germany) | |
| Viteron Forte (El Salvador, Guatemala, Honduras) | |
See 120 substitutes for Samjin Arginine | |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
