Actions of Sekitarl in details
Description: Sekitarl is a piperazine derivative sedating antihistamine. It also has mast-cell stabilising properties.
Pharmacokinetics:
Absorption: Almost completely absorbed from the GI tract. Peak plasma levels within 2 hr.
Distribution: Protein-binding: 98%.
Metabolism: Hepatic via aromatic hydroxylation, oxidative N-dealkylation and conjugation.
Excretion: Mainly via faeces (60%) from the bile; via urine. Half-life: 14 hr.
Sekitarl administration
Should be taken with food. Take after meals.
Sekitarl pharmacology
Sekitarl is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
References
- EPA DSStox. "Oxatomide: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Sekitarl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Sekitarl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
