What is Semintra 4 mg/ml for Cats?
Semintra 4 mg/ml for Cats is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can reduce the risk of strokes and heart attacks.
Semintra 4 mg/ml for Cats is also used to lower the risk of heart attacks or stroke in patients 55 years of age and older who have diabetes or heart problems.
Semintra 4 mg/ml for Cats is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. As a result, Semintra 4 mg/ml for Cats relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
Semintra 4 mg/ml for Cats is available only with your doctor's prescription.
Semintra 4 mg/ml for Cats indications
Hypertension: Treatment of essential hypertension.
Cardiovascular Risk Reduction: Semintra 4 mg/ml for Cats is indicated for reduction of the risk of myocardial infarction, stroke, or death from cardiovascular causes in patients 55 years of age or older at high risk of developing major cardiovascular events who are unable to take ACE inhibitors.
High risk of cardiovascular events can be evidenced by history of coronary artery disease, peripheral arterial disease, stroke, transient ischemic attack, or high-risk diabetes (insulin-dependent or non-insulin dependent) with evidence of end-organ damage. Semintra 4 mg/ml for Cats can be used in additional to other needed treatment (such as antihypertensive, antiplatelet or lipid-lowering therapy).
Studies of Semintra 4 mg/ml for Cats in this setting do not exclude that it may not preserve a meaningful fraction of the effect of the ACE inhibitor to which it was compared. Consider using the ACE inhibitor first, and, if it is stopped for cough only, consider re-trying the ACE inhibitor after the cough resolves.
Use of Semintra 4 mg/ml for Cats with an ACE inhibitor is not recommended.
How should I use Semintra 4 mg/ml for Cats?
Use Semintra 4 mg/ml for Cats as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Semintra 4 mg/ml for Cats. Talk to your pharmacist if you have questions about this information.
- Take Semintra 4 mg/ml for Cats by mouth with or without food.
- Do not remove the tablet from the blister seal until you are ready to take your dose.
- Take Semintra 4 mg/ml for Cats on a regular schedule to get the most benefit from it. Taking Semintra 4 mg/ml for Cats at the same time each day will help you remember to take it.
- Continue to take Semintra 4 mg/ml for Cats even if you feel well. Do not miss any doses.
- If you miss a dose of Semintra 4 mg/ml for Cats, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Semintra 4 mg/ml for Cats.
Uses of Semintra 4 mg/ml for Cats in details
Semintra 4 mg/ml for Cats belongs to a class of medicines known as angiotensin II receptor blockers. It is used to treat high blood pressure, prevention and treatment of heart attack (myocardial Infarction) and heart failure; when heart is unable to pump sufficient blood. It is also used for kidney failure in patients with diabetes.
Semintra 4 mg/ml for Cats description
Semintra 4 mg/ml for Cats is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as Semintra 4 mg/ml for Cats bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure. Recent studies suggest that Semintra 4 mg/ml for Cats may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.
Semintra 4 mg/ml for Cats dosage
Semintra 4 mg/ml for Cats Dosage
Generic name: Semintra 4 mg/ml for Cats 20mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
2.1 Hypertension
Dosage must be individualized. The usual starting dose of Semintra 4 mg/ml for Cats tablets is 40 mg once a day. Blood pressure response is dose-related over the range of 20 to 80 mg.
Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks. When additional blood pressure reduction beyond that achieved with 80 mg Semintra 4 mg/ml for Cats is required, a diuretic may be added.
No initial dosage adjustment is necessary for elderly patients or patients with renal impairment, including those on hemodialysis. Patients on dialysis may develop orthostatic hypotension; their blood pressure should be closely monitored.
Semintra 4 mg/ml for Cats tablets may be administered with other antihypertensive agents.
Semintra 4 mg/ml for Cats tablets may be administered with or without food.
2.2 Cardiovascular Risk Reduction
The recommended dose of Semintra 4 mg/ml for Cats tablets is 80 mg once a day and can be administered with or without food. It is not known whether doses lower than 80 mg of Semintra 4 mg/ml for Cats are effective in reducing the risk of cardiovascular morbidity and mortality.
When initiating Semintra 4 mg/ml for Cats therapy for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of medications that lower blood pressure may be necessary.
More about Semintra 4 mg/ml for Cats (Semintra 4 mg/ml for Cats)
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Consumer resources
- Semintra 4 mg/ml for Cats
- Semintra 4 mg/ml for Cats (Advanced Reading)
Professional resources
- Semintra 4 mg/ml for Cats (AHFS Monograph)
- Semintra 4 mg/ml for Cats (FDA)
Other formulations
- Semintra 4 mg/ml for Cats HCT
Related treatment guides
- Cardiovascular Risk Reduction
- High Blood Pressure
- Prevention of Cardiovascular Disease
Semintra 4 mg/ml for Cats interactions
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What other drugs will affect Semintra 4 mg/ml for Cats?
Aliskiren: Do not co-administer aliskiren with Semintra 4 mg/ml for Cats in patients with diabetes. Avoid use of aliskiren with Semintra 4 mg/ml for Cats in patients with renal impairment (GFR < 60 mL/min).
Digoxin: When Semintra 4 mg/ml for Cats was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed. Therefore, monitor digoxin levels when initiating, adjusting, and discontinuing Semintra 4 mg/ml for Cats for the purpose of keeping the digoxin level within the therapeutic range.
Lithium: Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists including Semintra 4 mg/ml for Cats. Therefore, monitor serum lithium levels during concomitant use.
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including Semintra 4 mg/ml for Cats, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Semintra 4 mg/ml for Cats and NSAID therapy.
The antihypertensive effect of angiotensin II receptor antagonists, including Semintra 4 mg/ml for Cats may be attenuated by NSAIDs including selective COX-2 inhibitors.
Ramipril and Ramiprilat: Co-administration of Semintra 4 mg/ml for Cats 80 mg once daily and ramipril 10 mg once daily to healthy subjects increases steady-state Cmax and AUC of ramipril 2.3-and 2.1-fold, respectively, and Cmax and AUC of ramiprilat 2.4-and 1.5-fold, respectively. In contrast, Cmax and AUC of Semintra 4 mg/ml for Cats decrease by 31% and 16%, respectively. When co-administering Semintra 4 mg/ml for Cats and ramipril, the response may be greater because of the possibly additive pharmacodynamic effects of the combined drugs, and also because of the increased exposure to ramipril and ramiprilat in the presence of Semintra 4 mg/ml for Cats. Concomitant use of Semintra 4 mg/ml for Cats and ramipril is not recommended.
Other Drugs: Co-administration of Semintra 4 mg/ml for Cats did not result in a clinically significant interaction with acetaminophen, amlodipine, glyburide, simvastatin, hydrochlorothiazide, warfarin, or ibuprofen. Semintra 4 mg/ml for Cats is not metabolized by the cytochrome P450 system and had no effects in vitro on cytochrome P450 enzymes, except for some inhibition of CYP2C19. Semintra 4 mg/ml for Cats is not expected to interact with drugs that inhibit cytochrome P450 enzymes; it is also not expected to interact with drugs metabolized by cytochrome P450 enzymes, except for possible inhibition of the metabolism of drugs metabolized by CYP2C19.
Semintra 4 mg/ml for Cats side effects
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What are the possible side effects of Semintra 4 mg/ml for Cats?
The following adverse reaction is described elsewhere in labeling:
Renal dysfunction upon use with ramipril
Clinical Trials Experience
Because clinical studies are conducted under widely varying conditions, adverse reactions rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.
Hypertension
Semintra 4 mg/ml for Cats has been evaluated for safety in more than 3700 patients, including 1900 treated for over 6 months and more than 1300 for over one year. Adverse experiences have generally been mild and transient in nature and have infrequently required discontinuation of therapy.
In placebo-controlled trials involving 1041 patients treated with various doses of Semintra 4 mg/ml for Cats (20 to 160 mg) monotherapy for up to 12 weeks, the overall incidence of adverse events was similar to that in patients treated with placebo.
Adverse events occurring at an incidence of ≥1% in patients treated with Semintra 4 mg/ml for Cats and at a greater rate than in patients treated with placebo, irrespective of their causal association, are presented in Table 1.
Table 1 Adverse Events Occurring at an Incidence of ≥1% in Patients Treated with Semintra 4 mg/ml for Cats and at a Greater Rate Than Patients Treated with Placebo
| Semintra 4 mg/ml for Cats n=1455 % | Placebo n=380 % | |
| Upper respiratory tract infection | 7 | 6 |
| Back pain | 3 | 1 |
| Sinusitis | 3 | 2 |
| Diarrhea | 3 | 2 |
| Pharyngitis | 1 | 0 |
In addition to the adverse events in the table, the following events occurred at a rate of ≥1% but were at least as frequent in the placebo group: influenza-like symptoms, dyspepsia, myalgia, urinary tract infection, abdominal pain, headache, dizziness, pain, fatigue, coughing, hypertension, chest pain, nausea, and peripheral edema. Discontinuation of therapy because of adverse events was required in 2.8% of 1455 patients treated with Semintra 4 mg/ml for Cats tablets and 6.1% of 380 placebo patients in placebo-controlled clinical trials.
The incidence of adverse events was not dose-related and did not correlate with gender, age, or race of patients.
The incidence of cough occurring with Semintra 4 mg/ml for Cats in 6 placebo-controlled trials was identical to that noted for placebo-treated patients (1.6%).
In addition to those listed above, adverse events that occurred in more than 0.3% of 3500 patients treated with Semintra 4 mg/ml for Cats monotherapy in controlled or open trials are listed below. It cannot be determined whether these events were causally related to Semintra 4 mg/ml for Cats tablets:
Autonomic Nervous System: impotence, increased sweating, flushing; Body as a Whole: allergy, fever, leg pain, malaise; Cardiovascular: palpitation, dependent edema, angina pectoris, tachycardia, leg edema, abnormal ECG; CNS: insomnia, somnolence, migraine, vertigo, paresthesia, involuntary muscle contractions, hypoesthesia; Gastrointestinal: flatulence, constipation, gastritis, vomiting, dry mouth, hemorrhoids, gastroenteritis, enteritis, gastroesophageal reflux, toothache, non-specific gastrointestinal disorders; Metabolic: gout, hypercholesterolemia, diabetes mellitus; Musculoskeletal: arthritis, arthralgia, leg cramps; Psychiatric: anxiety, depression, nervousness; Resistance Mechanism: infection, fungal infection, abscess, otitis media; Respiratory: asthma, bronchitis, rhinitis, dyspnea, epistaxis; Skin: dermatitis, rash, eczema, pruritus; Urinary: micturition frequency, cystitis; Vascular: cerebrovascular disorder; and Special Senses: abnormal vision, conjunctivitis, tinnitus, earache.
During initial clinical studies, a single case of angioedema was reported (among a total of 3781 patients treated).
Clinical Laboratory Findings
In placebo-controlled clinical trials, clinically relevant changes in standard laboratory test parameters were rarely associated with administration of Semintra 4 mg/ml for Cats tablets.
Hemoglobin: A greater than 2 g/dL decrease in hemoglobin was observed in 0.8% Semintra 4 mg/ml for Cats patients compared with 0.3% placebo patients. No patients discontinued therapy because of anemia.
Creatinine: A 0.5 mg/dL rise or greater in creatinine was observed in 0.4% Semintra 4 mg/ml for Cats patients compared with 0.3% placebo patients. One Semintra 4 mg/ml for Cats-treated patient discontinued therapy because of increases in creatinine and blood urea nitrogen.
Liver Enzymes: Occasional elevations of liver chemistries occurred in patients treated with Semintra 4 mg/ml for Cats; all marked elevations occurred at a higher frequency with placebo. No Semintra 4 mg/ml for Cats-treated patients discontinued therapy because of abnormal hepatic function.
Cardiovascular Risk Reduction
Because common adverse reactions were well characterized in studies of Semintra 4 mg/ml for Cats in hypertension, only adverse events leading to discontinuation and serious adverse events were recorded in subsequent studies of Semintra 4 mg/ml for Cats for cardiovascular risk reduction. In TRANSCEND (N=5926, 4 years and 8 months of follow-up), discontinuations for adverse events were 8.4% on Semintra 4 mg/ml for Cats and 7.6% on placebo. The only serious adverse events at least 1% more common on Semintra 4 mg/ml for Cats than placebo were intermittent claudication (7% vs 6%) and skin ulcer (3% vs 2%).
Postmarketing Experience
The following adverse reactions have been identified during post-approval use of Semintra 4 mg/ml for Cats. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure. Decisions to include these reactions in labeling are typically based on one or more of the following factors: (1) seriousness of the reaction, (2) frequency of reporting, or (3) strength of causal connection to Semintra 4 mg/ml for Cats.
The most frequent spontaneously reported events include: headache, dizziness, asthenia, coughing, nausea, fatigue, weakness, edema, face edema, lower limb edema, angioneurotic edema, urticaria, hypersensitivity, sweating increased, erythema, chest pain, atrial fibrillation, congestive heart failure, myocardial infarction, blood pressure increased, hypertension aggravated, hypotension (including postural hypotension), hyperkalemia, syncope, dyspepsia, diarrhea, pain, urinary tract infection, erectile dysfunction, back pain, abdominal pain, muscle cramps (including leg cramps), myalgia, bradycardia, eosinophilia, thrombocytopenia, uric acid increased, abnormal hepatic function/liver disorder, renal impairment including acute renal failure, anemia, increased CPK, anaphylactic reaction, tendon pain (including tendonitis, tenosynovitis), drug eruption (toxic skin eruption mostly reported as toxicoderma, rash, and urticaria), hypoglycemia (in diabetic patients), and angioedema (with fatal outcome).
Rare cases of rhabdomyolysis have been reported in patients receiving angiotensin II receptor blockers, including Semintra 4 mg/ml for Cats.
Semintra 4 mg/ml for Cats contraindications
See also:
What is the most important information I should know about Semintra 4 mg/ml for Cats?
Hypersensitivity to Semintra 4 mg/ml for Cats or to any of the excipients of Semintra 4 mg/ml for Cats.
Biliary obstructive disorders and severe hepatic impairment.
The concomitant use with aliskiren is contraindicated in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m2).
In case of rare hereditary conditions that may be incompatible with an excipient of Semintra 4 mg/ml for Cats, the use of Semintra 4 mg/ml for Cats is contraindicated.
Use in pregnancy: The use of angiotensin II receptor antagonists is not recommended during the 1st trimester of pregnancy and should not be initiated during pregnancy.
Nonclinical studies with Semintra 4 mg/ml for Cats do not indicate teratogenic effect, but have shown fetotoxicity.
Angiotensin II receptor antagonist exposure during the 2nd and 3rd trimester is known to induce human fetotoxicity (decreased renal function, oligohydramnios, skull ossification retardation) and neonatal toxicity (renal failure, hypotension, hyperkalemia).
Unless continued and angiotensin II receptor antagonist therapy is considered essential, patients planning pregnancy should be changed to alternative antihypertensive treatments which have an established safety profile for use in pregnancy. When pregnancy is diagnosed, treatment with angiotensin II receptor antagonist should be stopped immediately and if appropriate, alternative therapy should be started.
Should exposure to angiotensin II receptor antagonists have occurred from the 2nd trimester of pregnancy, ultrasound check of renal function and skull is recommended.
Infants whose mothers have taken angiotensin II receptor antagonist should be closely observed for hypotension.
Use in lactation: Semintra 4 mg/ml for Cats is contraindicated during lactation since it is not known whether it is excreted in human milk.
Animal studies have shown excretion of Semintra 4 mg/ml for Cats in breast milk.
Active ingredient matches for Semintra 4 mg/ml for Cats:
Telmisartan in Australia.
List of Semintra 4 mg/ml for Cats substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Semintra chats (Belgium) | |
| Sha Tai Qi (China) | |
| Sha Ting Ning (China) | |
| Shang Er Ning (China) | |
| Shi Ji (China) | |
| Shu Luo Ning (China) | |
| Si Tai Le (China) | |
| Simtel | |
| Simtel 40 mg Tablet (Research Medicure Pvt. Ltd.) | $ 0.09 |
| Siterbon (Portugal) | |
| SLEW | |
| SLEW 20 MG TABLET 1 strip / 10 tablets each (Avinash Health Products Pvt Ltd) | $ 0.34 |
| SLEW 40 MG TABLET 1 strip / 10 tablets each (Avinash Health Products Pvt Ltd) | $ 0.66 |
| Slew 20mg Tablet (Avinash Health Products Pvt Ltd) | $ 0.03 |
| Slew 40mg Tablet (Avinash Health Products Pvt Ltd) | $ 0.07 |
| Sonia (China) | |
| STALIA | |
| STALIA 20MG TABLET 1 strip / 10 tablets each (Wanbury Ltd) | $ 0.41 |
| STALIA 40MG TABLET 1 strip / 10 tablets each (Wanbury Ltd) | $ 0.83 |
| Stalia 40mg Tablet (Wanbury Ltd) | $ 0.08 |
| STARTEL (India) | |
| 40 mg x 10's (Invision Medi Sciences) | $ 0.84 |
| Startel 40 mg Tablet (Invision Medi Sciences) | $ 0.08 |
| Startel 40mg TAB / 10 (Invision Medi Sciences) | $ 0.84 |
| STARTEL tab 40 mg x 10's (Invision Medi Sciences) | $ 0.90 |
| Startel 40mg TAB / 10 (Invision Medi Sciences) | $ 0.84 |
| Startel H | |
| Startel H 40+12.5 Tablet (Invision Medi Sciences) | $ 0.10 |
| Su Ding (China) | |
| SUPERTEL | |
| SUPERTEL TABLET 1 strip / 10 tablets each (Gland Pharma Limited) | $ 0.79 |
| T MART | |
| T Mart 20mg Tablet (Wallace Pharmaceuticals Pvt Ltd) | $ 0.04 |
| T Mart R Tablet (Wallace Pharmaceuticals Pvt Ltd) | $ 0.17 |
| T Press | |
| T Press 20mg TAB / 100 (Talent Laboratories) | $ 4.22 |
| T Press 40mg TAB / 100 (Talent Laboratories) | $ 7.11 |
| T Press 40 mg Tablet (Talent Laboratories) | $ 0.07 |
| T Press 20 mg Tablet (Talent Laboratories) | $ 0.04 |
| T-Mart (India) | |
| T-Mart 40mg TAB / 10 (Wallace (Lyfestyle DC)) | $ 0.78 |
| T-MART 40 MG TABLET 1 strip / 10 tablets each (Wallace (Lyfestyle DC)) | $ 0.77 |
| T-MART tab 40 mg x 10's (Wallace (Lyfestyle DC)) | $ 0.78 |
| T-PRESS (India) | |
| 20 mg x 100's (Talent) | $ 4.22 |
| 40 mg x 100's (Talent) | $ 7.11 |
| T-Press 20mg TAB / 100 (Talent) | $ 4.22 |
| T-Press 40mg TAB / 100 (Talent) | $ 7.11 |
| T-PRESS tab 20 mg x 30's (Talent) | $ 0.84 |
| T-PRESS tab 40 mg x 30's (Talent) | $ 1.42 |
| T-Press 20mg TAB / 100 (Talent) | $ 4.22 |
| T-Press 40mg TAB / 100 (Talent) | $ 7.11 |
See 1793 substitutes for Semintra 4 mg/ml for Cats | |
References
- DailyMed. "AMLODIPINE BESYLATE; TELMISARTAN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "Telmisartan". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "Telmisartan". http://www.drugbank.ca/drugs/DB00966 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
