Dosage of Semintra 4 mg/ml for Cats in details
Semintra 4 mg/ml for Cats Dosage
Generic name: Semintra 4 mg/ml for Cats 20mg
Dosage form: tablet
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2.1 Hypertension
Dosage must be individualized. The usual starting dose of Semintra 4 mg/ml for Cats tablets is 40 mg once a day. Blood pressure response is dose-related over the range of 20 to 80 mg.
Most of the antihypertensive effect is apparent within 2 weeks and maximal reduction is generally attained after 4 weeks. When additional blood pressure reduction beyond that achieved with 80 mg Semintra 4 mg/ml for Cats is required, a diuretic may be added.
No initial dosage adjustment is necessary for elderly patients or patients with renal impairment, including those on hemodialysis. Patients on dialysis may develop orthostatic hypotension; their blood pressure should be closely monitored.
Semintra 4 mg/ml for Cats tablets may be administered with other antihypertensive agents.
Semintra 4 mg/ml for Cats tablets may be administered with or without food.
2.2 Cardiovascular Risk Reduction
The recommended dose of Semintra 4 mg/ml for Cats tablets is 80 mg once a day and can be administered with or without food. It is not known whether doses lower than 80 mg of Semintra 4 mg/ml for Cats are effective in reducing the risk of cardiovascular morbidity and mortality.
When initiating Semintra 4 mg/ml for Cats therapy for cardiovascular risk reduction, monitoring of blood pressure is recommended, and if appropriate, adjustment of medications that lower blood pressure may be necessary.
More about Semintra 4 mg/ml for Cats (Semintra 4 mg/ml for Cats)
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Consumer resources
- Semintra 4 mg/ml for Cats
- Semintra 4 mg/ml for Cats (Advanced Reading)
Professional resources
- Semintra 4 mg/ml for Cats (AHFS Monograph)
- Semintra 4 mg/ml for Cats (FDA)
Other formulations
- Semintra 4 mg/ml for Cats HCT
Related treatment guides
- Cardiovascular Risk Reduction
- High Blood Pressure
- Prevention of Cardiovascular Disease
What other drugs will affect Semintra 4 mg/ml for Cats?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Semintra 4 mg/ml for Cats, especially:
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digoxin;
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lithium;
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a diuretic or "water pill";
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NSAIDs (non-steroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, or meloxicam, and others; or
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ramipril or other blood pressure medicines.
This list is not complete. Other drugs may interact with Semintra 4 mg/ml for Cats, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Semintra 4 mg/ml for Cats interactions
Aliskiren: Do not co-administer aliskiren with Semintra 4 mg/ml for Cats in patients with diabetes. Avoid use of aliskiren with Semintra 4 mg/ml for Cats in patients with renal impairment (GFR < 60 mL/min).
Digoxin: When Semintra 4 mg/ml for Cats was co-administered with digoxin, median increases in digoxin peak plasma concentration (49%) and in trough concentration (20%) were observed. Therefore, monitor digoxin levels when initiating, adjusting, and discontinuing Semintra 4 mg/ml for Cats for the purpose of keeping the digoxin level within the therapeutic range.
Lithium: Reversible increases in serum lithium concentrations and toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists including Semintra 4 mg/ml for Cats. Therefore, monitor serum lithium levels during concomitant use.
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including Semintra 4 mg/ml for Cats, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving Semintra 4 mg/ml for Cats and NSAID therapy.
The antihypertensive effect of angiotensin II receptor antagonists, including Semintra 4 mg/ml for Cats may be attenuated by NSAIDs including selective COX-2 inhibitors.
Ramipril and Ramiprilat: Co-administration of Semintra 4 mg/ml for Cats 80 mg once daily and ramipril 10 mg once daily to healthy subjects increases steady-state Cmax and AUC of ramipril 2.3-and 2.1-fold, respectively, and Cmax and AUC of ramiprilat 2.4-and 1.5-fold, respectively. In contrast, Cmax and AUC of Semintra 4 mg/ml for Cats decrease by 31% and 16%, respectively. When co-administering Semintra 4 mg/ml for Cats and ramipril, the response may be greater because of the possibly additive pharmacodynamic effects of the combined drugs, and also because of the increased exposure to ramipril and ramiprilat in the presence of Semintra 4 mg/ml for Cats. Concomitant use of Semintra 4 mg/ml for Cats and ramipril is not recommended.
Other Drugs: Co-administration of Semintra 4 mg/ml for Cats did not result in a clinically significant interaction with acetaminophen, amlodipine, glyburide, simvastatin, hydrochlorothiazide, warfarin, or ibuprofen. Semintra 4 mg/ml for Cats is not metabolized by the cytochrome P450 system and had no effects in vitro on cytochrome P450 enzymes, except for some inhibition of CYP2C19. Semintra 4 mg/ml for Cats is not expected to interact with drugs that inhibit cytochrome P450 enzymes; it is also not expected to interact with drugs metabolized by cytochrome P450 enzymes, except for possible inhibition of the metabolism of drugs metabolized by CYP2C19.
References
- DailyMed. "AMLODIPINE BESYLATE; TELMISARTAN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "U5SYW473RQ: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Angiotensin II Type 1 Receptor Blockers". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
