What is Siguran E Plus?
Siguran E Plus contains a combination of Acetaminophen (Siguran E Plus), aspirin, and Caffeine (Siguran E Plus). Acetaminophen (Siguran E Plus) is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates. It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine (Siguran E Plus) is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
Siguran E Plus is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.
Siguran E Plus may also be used for purposes not listed in this medication guide.
Siguran E Plus indications
This medication contains a combination of Acetaminophen (Siguran E Plus), aspirin, and Caffeine (Siguran E Plus). Acetaminophen (Siguran E Plus) is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine (Siguran E Plus) is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.
This medication is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.
Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.
How should I use Siguran E Plus?
Use Acetaminophen (Siguran E Plus)/Caffeine (Siguran E Plus) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Acetaminophen (Siguran E Plus)/Caffeine (Siguran E Plus) may be taken with or without food.
- If you miss a dose of Acetaminophen (Siguran E Plus)/Caffeine (Siguran E Plus) and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Acetaminophen (Siguran E Plus)/Caffeine (Siguran E Plus).
Uses of Siguran E Plus in details
Use: Labeled Indications
Pain: For the temporary relief of pain caused by headache or muscle aches
Siguran E Plus description
Each caplet contains Acetaminophen (Siguran E Plus) 500 mg and Caffeine (Siguran E Plus) 65 mg.
Siguran E Plus dosage
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Tablet,
Oral:
Siguran E Plus Tension Headache: Acetaminophen (Siguran E Plus) 500 mg and Caffeine (Siguran E Plus) 65 mg [contains benzoic acid, brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #6 (sunset yellow)]
Siguran E Plus Tension Headache: Acetaminophen (Siguran E Plus) 500 mg and Caffeine (Siguran E Plus) 65 mg [DSC] [contains benzoic acid, fd&c blue #1 aluminum lake, fd&c red #40, fd&c yellow #10 aluminum lake]
Siguran E Plus Tension Headache: Acetaminophen (Siguran E Plus) 500 mg and Caffeine (Siguran E Plus) 65 mg [aspirin free; contains benzoic acid, fd&c blue #1 aluminum lake, fd&c red #40]
Siguran E Plus Tension Headache: Acetaminophen (Siguran E Plus) 500 mg and Caffeine (Siguran E Plus) 65 mg [DSC] [aspirin free; contains fd&c blue #2 aluminum lake, fd&c yellow #6 aluminum lake]
Dosing: Adult
Pain:
Oral: Acetaminophen (Siguran E Plus) 1 g/Caffeine (Siguran E Plus) 130 mg every 6 hours as needed (maximum: Acetaminophen (Siguran E Plus) 3 g/Caffeine (Siguran E Plus) 390 mg per 24 hours)
Dosing: Geriatric
Refer to adult dosing.
Dosing: Pediatric
Pain: Children ≥12 years and Adolescents: Refer to adult dosing.
Siguran E Plus interactions
See also:
What other drugs will affect Siguran E Plus?
Acetaminophen (Siguran E Plus) is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen (Siguran E Plus) [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen (Siguran E Plus) and may decrease the action of Acetaminophen (Siguran E Plus). Doses of Acetaminophen (Siguran E Plus) greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen (Siguran E Plus) to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Acetaminophen (Siguran E Plus) by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen (Siguran E Plus) should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen (Siguran E Plus) doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen (Siguran E Plus) should be avoided during warfarin therapy
Siguran E Plus side effects
See also:
What are the possible side effects of Siguran E Plus?
Get emergency medical help if you have any of these signs of an allergic reaction to Siguran E Plus: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:
weakness or fainting;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
severe nausea, vomiting, or stomach pain;
redness or swelling;
low fever with nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
fever lasting longer than 3 days;
pain lasting longer than 10 days; or
hearing problems, ringing in your ears.
Less serious side effects may include:
upset stomach, heartburn;
feeling nervous or excited; or
sleep problems (insomnia).
Siguran E Plus contraindications
See also:
What is the most important information I should know about Siguran E Plus?
This medicaion should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin in this medicine can cause a serious and sometimes fatal condition called Reye’s syndrome in children. You should not use this if you are allergic to Acetaminophen (Siguran E Plus) (Tylenol), aspirin, or Caffeine (Siguran E Plus), or if you have:
a recent history of stomach or intestinal bleeding;
liver disease;
asthma or severe allergic reaction caused by taking aspirin or a non-steroidal anti-inflammatory drug (NSAID), especially "aspirin triad syndrome"; or
if you are allergic to an NSAID such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:
asthma or seasonal allergies;
fever with a stiff neck;
a stomach ulcer, heartburn, or stomach pain;
a bleeding or blood clotting disorder such as hemophilia;
diabetes; or
gout.
Active ingredient matches for Siguran E Plus:
Acetaminophen/Caffeine in Germany.
Caffeine/Paracetamol in Germany.
List of Siguran E Plus substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Sevedol (Colombia) | |
| Sindo (Mexico) | |
| Tablet; Oral; Acetaminophen; Caffeine (Nordin) | |
| Skdol Cafein (Vietnam) | |
| Skdol Cafein 3 Blister x 10 Tablet | |
| Skdol Cafein 6 Blister x 10 Tablet | |
| Skdol Cafein 10 Blister x 10 Tablet | |
| Skdol Cafein 25 Blister x 10 Tablet | |
| Skdol Cafein 30 Blister x 10 Tablet | |
| Skdol Cafein 50 Blister x 10 Tablet | |
| Skdol Cafein 1 Bottle 100 Tablet | |
| Skdol Cafein 1 Bottle 250 Tablet | |
| Skdol Cafein 1 Bottle 500 Tablet | |
| solpa-extra (Ireland) | |
| Solpadeine (United Kingdom) | |
| Capsule; Oral; Acetaminophen 500 mg; Caffeine 30 mg; Codeine Phosphate 8 mg (Glaxosmithkline consumer healthcare) | |
| Tablet, Orally Disintegrating; Oral; Acetaminophen 500 mg; Caffeine 30 mg; Codeine Phosphate 8 mg (Glaxosmithkline consumer healthcare) | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 30 mg; Codeine Phosphate 8 mg (Glaxosmithkline consumer healthcare) | |
| Solpadeine Express (Estonia, Lithuania) | |
| Solpadeine Extracaf (Romania) | |
| Solpadeine Headache (United Kingdom) | |
| Tablet; Oral; Acetaminophen 500 mg; Caffeine 65 mg (Gsk consumer) | |
| Sonridor caf (Brazil) | |
| STOPACHE | |
| STOPACHE TABLET 1 strip / 10 tablets each (Paras Pharmaceuticals Ltd) | $ 0.13 |
| Stopalgic extra (Tunisia) | |
| Sudis MR | |
| Tablet, Film-Coated; Oral; Acetaminophen 500 mg; Caffeine 50 mg | |
| Tachicaf (Italy) | |
| Tamen-X (Bangladesh) | |
| Tapsin 2 Analgesico (Chile) | |
| Tapsin Analgesico (Chile) | |
| Tablet; Oral; Acetaminophen 400 mg; Caffeine 33 mg (Maver) | |
| Tapsin Analgésico (Chile, Peru) | |
| Tablet; Oral; Acetaminophen 400 mg; Caffeine 33 mg | |
| Tablet; Oral; Acetaminophen 400 mg; Caffeine 33 mg | |
| Tapsin Forte (Chile) | |
| Tapsin UP | |
| Tatanol Plus (Vietnam) | |
| Tatanol Plus 20 Blister x 4 Tablet, 10 Blister x 10 Tablet | |
| Tatanol Plus 20 Blister x 4 Tablet | |
| Tatanol Plus 10 Blister x 10 Tablet | |
| Temagin Paracetamol plus (Germany) | |
| Tempol Plus (Bangladesh) | |
| Tempra MF (Mexico) | |
| Tempra Plus | |
| Tempraplus (Venezuela) | |
| Temrif Plus (Bangladesh) | |
| Termalgine Plus (Turkey) | |
| Tablet; Oral; Acetaminophen; 500 mg; Caffeine 30 mg (Novartis) | |
| Théinol (France) | |
| Solution; Oral; Acetaminophen 405 mg; Caffeine Monohydrate 39.9 mg / 5 ml | |
| Theinol | |
| Solution; Oral; Acetaminophen 405 mg; Caffeine Monohydrate 39.9 mg / 5 ml | |
See 508 substitutes for Siguran E Plus | |
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "caffeine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Siguran E Plus are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Siguran E Plus. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
No survey data has been collected yetConsumer reported price estimates
No survey data has been collected yetConsumer reported time for results
No survey data has been collected yetConsumer reported age
No survey data has been collected yetConsumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
