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Dosage of Sortum in details
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Important Administration Instructions
- Sortum tablets USP and Sortum for oral suspension are not bioequivalent and are therefore not substitutable on a milligram-per-milligram basis.
- Administer Sortum tablets USP tablets as described in the appropriate dosage guidelines.
- Administer Sortum tablets USP with or without food.
- Pediatric patients (aged 13 years and older) who cannot swallow the Sortum tablets USP whole should receive Sortum for oral suspension because the tablet has a strong, persistent bitter taste when crushed.
Dosage for Sortum tablets USP
Administer Sortum tablets USP as described in the dosage guidelines table below with or without food.
| Infection | Dosage | Duration (Days) |
| Adults and Adolescents (13 years and older) | ||
| Pharyngitis/tonsillitis (mild to moderate) | 250 mg every 12 hours | 10 |
| Acute bacterial maxillary sinusitis (mild to moderate) | 250 mg every 12 hours | 10 |
| Acute bacterial exacerbations of chronic bronchitis (mild to moderate) | 250 or 500 mg every 12 hours | 10a |
| Secondary bacterial infections of acute bronchitis | 250 or 500 mg every 12 hours | 5 to 10 |
| Uncomplicated skin and skin-structure infections | 250 or 500 mg every 12 hours | 10 |
| Uncomplicated urinary tract infections | 250 mg every 12 hours | 7 to 10 |
| Uncomplicated gonorrhea | 1,000 mg | single dose |
| Early Lyme disease | 500 mg every 12 hours | 20 |
| Pediatric Patients younger than 13 years (who can swallow tablets whole)b | ||
| Acute bacterial otitis media | 250 mg every 12 hours | 10 |
| Acute bacterial maxillary sinusitis | 250 mg every 12 hours | 10 |
Dosage in Patients with Impaired Renal Function
A dosage interval adjustment is required for patients whose creatinine clearance is <30 mL/min, as listed in Table 4 below, because Sortum is eliminated primarily by the kidney.
| Creatinine Clearance (mL/min) | Recommended Dosage |
| ≥30 | No dosage adjustment |
| 10 to ˂30 | Standard individual dose given every 24 hours |
| ˂10 (without hemodialysis) | Standard individual dose given every 48 hours |
| Hemodialysis | A single additional standard dose should be given at the end of each dialysis |
Sortum interactions
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Concomitant administration of probenecid with Sortum tablets increases the area under the serum concentration versus time curve by 50%. The peak serum Sortum concentration after 1.5-g single dose is greater when taken with probenecid 1 g than without probenecid. Drugs that reduce gastric acidity may result in a lower bioavailability of Sortum compared with that of fasting state and tend to cancel the effect of postprandial absorption.
References
- FDA/SPL Indexing Data. "O1R9FJ93ED: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- European Chemicals Agency - ECHA. "Cefuroxime: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Sortum are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Sortum. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yet2 consumers reported doses
What doses of Sortum drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Sortum drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 201-500mg | 2 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
