Actions of Sp-Mucoplex in details
Sp-Mucoplex, a derivative of acetylcysteine, is a mucoregulating agent. Its major action is thought to be on the metabolism of mucus-producing cells. The mucus produced under the influence of Sp-Mucoplex has an increased content of the less viscous sialomucin and a reduced content of the highly viscous fucomucin. Sialomucins influence the rheological properties of mucus and may also, through the inhibition of kinins, reduce or prevent bronchial inflammation and bronchospasm.
Sp-Mucoplex is rapidly and well-absorbed after oral administration. Following oral administration of 1.5 g Sp-Mucoplex, peak serum concentration of 13-16 mg/L was reached in 1-2 hrs. Plasma t½ was 1.5-2 hrs. Sp-Mucoplex penetrates well into lung tissues and respiratory mucus suggesting local action. Sp-Mucoplex undergoes acetylation, decarboxylation and sulfoxidation. Majority of Sp-Mucoplex is excreted unchanged in the urine.
Sp-Mucoplex administration
Should be taken with food.
Sp-Mucoplex pharmacology
Sp-Mucoplex enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
