Actions of Spasmo-PROXYVON INJ in details
Spasmo-PROXYVON INJ relieves smooth muscle spasm of the gastrointestinal tract. Animal studies indicate that this action is achieved via a dual mechanism:
- a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites with approximately 1/8 the milligram potency of atropine (in vitro, guinea pig ileum); and
- a direct effect upon smooth muscle (musculotropic) as evidenced by Spasmo-PROXYVON INJ's antagonism of bradykinin- and histamine-induced spasms of the isolated guinea pig ileum.
Atropine did not affect responses to these two agonists. In vivo studies in cats and dogs showed Spasmo-PROXYVON INJ to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl2)-induced intestinal spasm while atropine was at least 200 times more potent against effects of ACh than BaCl2. Tests for mydriatic effects in mice showed that Spasmo-PROXYVON INJ was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Spasmo-PROXYVON INJ to be 1/300 as potent as atropine.
How should I take Spasmo-PROXYVON INJ?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Spasmo-PROXYVON INJ oral is taken by mouth.
Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).
Spasmo-PROXYVON INJ injection is given in a muscle if you are unable to take the medicine by mouth.
Call your doctor if your symptoms do not improve after 2 weeks.
Store at room temperature away from moisture and heat.
Detailed Spasmo-PROXYVON INJ dosage information Free Drugs.com Discount Card
- Save up to 80% on your prescriptions.
- Accepted at over 65,000 pharmacies.
Spasmo-PROXYVON INJ administration
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Spasmo-PROXYVON INJ is usually taken 4 times each day. Your doctor may occasionally change your dose to make sure you get the best results.
Take this medicine with a full glass of water.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Talk with your doctor if your symptoms do not improve after 2 weeks of treatment.
Store at room temperature away from moisture and heat.
Spasmo-PROXYVON INJ pharmacology
Mechanism Of Action
Spasmo-PROXYVON INJ relieves smooth muscle spasm of the gastrointestinal tract. Animal studies indicate that this action is achieved via a dual mechanism:
- a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites with approximately 1/8 the milligram potency of atropine (in vitro, guinea pig ileum); and
- a direct effect upon smooth muscle (musculotropic) as evidenced by Spasmo-PROXYVON INJ's antagonism of bradykinin- and histamine-induced spasms of the isolated guinea pig ileum.
Atropine did not affect responses to these two agonists. In vivo studies in cats and dogs showed Spasmo-PROXYVON INJ to be equally potent against acetylcholine (ACh)- or barium chloride (BaCl. Tests for mydriatic effects in mice showed that Spasmo-PROXYVON INJ was approximately 1/500 as potent as atropine; antisialagogue tests in rabbits showed Spasmo-PROXYVON INJ to be 1/300 as potent as atropine.
Pharmacodynamics
Spasmo-PROXYVON INJ can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, cause drowsiness, dilate the pupils, increase heart rate, and depress motor function.
Pharmacokinetics
Absorption And Distribution
In man, Spasmo-PROXYVON INJ is rapidly absorbed after oral administration, reaching peak values within 60-90 minutes. Mean volume of distribution for a 20 mg oral dose is approximately 3.65 L/kg suggesting exentsive distribution in tissues.
Elimination
The metabolism of Spasmo-PROXYVON INJ was not studied. The principal route of excretion is via the urine (79.5% of the dose). Excretion also occurs in the feces, but to a lesser extent (8.4%). Mean half-life of plasma elimination in one study was determined to be approximately 1.8 hours when plasma concentrations were measured for 9 hours after a single dose. In subsequent studies, plasma concentrations were followed for up to 24 hours after a single dose, showing a secondary phase of elimination with a somewhat longer half-life.
Clinical Studies
In controlled clinical trials involving over 100 patients who received drug, 82% of patients treated for functional bowel/irritable bowel syndrome with Spasmo-PROXYVON INJ at initial doses of 160 mg daily (40 mg four times daily) demonstrated a favorable clinical response compared with 55% treated with placebo (p<0.05).
References
- NCIt. "Dicyclomine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Dicyclomine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Spasmo-PROXYVON INJ are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Spasmo-PROXYVON INJ. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported administration
When best can I take Spasmo-PROXYVON INJ, on an empty stomach, before or after food?ndrugs.com website users have also released a report stating that Spasmo-PROXYVON INJ should be taken After food. In any case, this may not be the right description on how you ought to take this Spasmo-PROXYVON INJ. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Spasmo-PROXYVON INJ can be taken.
| Users | % | ||
|---|---|---|---|
| After food | 1 | 100.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
