Actions of Spiramycine 1.5 in details
Description: Spiramycine 1.5 is a macrolide antibacterial that inhibits protein synthesis by irreversibly binding to the 50S subunit of the ribosomal subunit thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Pharmacokinetics:
Absorption: Incompletely absorbed from the GI tract (oral); peak plasma concentrations after 1.5-3 hr.
Distribution: Widely distributed into tissues, enters breast milk. Protein binding: 10-25%.
Metabolism: Metabolised hepatically to active metabolites.
Excretion: Via bile (as metabolites), via urine (10%); 5-8 hr (elimination half-life).
How should I take Spiramycine 1.5?
Spiramycine 1.5 is best taken on an empty stomach.
To help clear up your infection completely, keep taking Spiramycine 1.5 for the full time of treatment, even if you begin to feel better after a few days. If you stop taking Spiramycine 1.5 too soon, your symptoms may return.
Spiramycine 1.5 works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times day and night. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.
For patients using Spiramycine 1.5 suppositories:
- First remove the foil wrapper and moisten the suppository with cold water. Lie down on your side and use your finger to push the suppository well up into the rectum.
Dosing
The dose of Spiramycine 1.5 will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Spiramycine 1.5. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage forms (capsules or tablets):
- For treatment of infections:
- Adults and teenagers—1 to 2 grams (3,000,000 to 6,000,000 International Units [IU]) two times a day, or 500 mg to 1 gram (1,500,000 to 3,000,000 IU) three times a day. For severe infections, the dose is 2 to 2.5 grams (6,000,000 to 7,500,000 IU) two times a day.
- Children weighing 20 kilograms (kg) (44 pounds) or more—Dose is based on body weight. The usual dose is 25 mg (75,000 IU) per kg (11.4 mg per pound) of body weight two times a day, or 17 mg (51,000 IU) per kg (7.7 mg per pound) of body weight three times a day.
- For treatment of infections:
- For injection dosage form:
- For treatment of infections:
- Adults and teenagers—500 mg (1,500,000 IU) injected slowly into a vein every eight hours. For severe infections, the dose is 1 gram (3,000,000 IU) injected slowly into a vein every eight hours.
- Children—Use and dose must be determined by your doctor.
- For treatment of infections:
- For rectal dosage form (suppository):
- For treatment of infections:
- Adults and children 12 years of age and over—Two or three 750 mg (1,950,000 IU) suppositories per day.
- Children up to 12 years of age—Two or three 500 mg (1,300,000 IU) suppositories per day.
- Newborns—Dose is based on body weight. The usual dose is one 250 mg (650,000 IU) suppository per 5 kg (250 mg suppository per 11 pounds) of body weight once a day.
- For treatment of infections:
Missed Dose
If you miss a dose of Spiramycine 1.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Spiramycine 1.5 administration
May be taken with or without food.
Spiramycine 1.5 pharmacology
Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Reviews
The results of a survey conducted on ndrugs.com for Spiramycine 1.5 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Spiramycine 1.5. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
