Sulphamethoxazole/trimethoprim indications
Infectious-inflammatory diseases caused by sensitive to co-trimoxazole microorganisms: respiratory tract infections (including acute and chronic bronchitis, empyema, bronchiectasis, lung abscess, pneumonia, tonsillitis, pharyngitis); urinary tract infections (including gonococcal urethritis), cystitis, pyelonephritis, prostatitis; gastrointestinal infections (including enteritis, typhoid, paratyphoid, dysentery, cholecystitis, cholangitis); infections of skin and soft tissue (including pyoderma, furunculosis, wound infection), septicemia, brucellosis.
Sulphamethoxazole/trimethoprim dosage
Individual. Doses of Sulphamethoxazole/trimethoprim are given on the basis of sulfamethoxazole. For oral administration for adults and children older than 12 years the average dose is 0.4-2 g every 12 hours (2 times / day), course of treatment - 5-14 days.
Orally for children aged 2-5 months - 100 mg 2 times / day; 1-2 years - 100 mg 2 times / day; 3-6 years - 200 mg 2 times / day; 6-12 years at 200-400 mg 2 times / day.
Parenterally administered only in the absence of the possibility of oral administration. IM for adults and children over 12 years - 800 mg every 12 hours; for children aged 6-12 years - 30 mg / kg / day, interval between each dose - 12 hours.
If necessary prescribed IV as drops at 0.8-1.6 g every 12 hours (2 times / day) within 5 days. For children aged 6-12 years are prescribed at 15 mg / kg every 12 hours. Average duration of Sulphamethoxazole/trimethoprim injection - 30-60 minutes but no more than 1.5 hours. The course of treatment is average 5 days, then if necessary go to oral administration. The maximum oral daily dose for adults is 3.6 g.
Sulphamethoxazole/trimethoprim interactions
With the simultaneous application of co-trimoxazole effect of anticoagulants of indirect action is greatly enhanced due to slow inactivation of the latter, as well as their release from binding with plasma proteins.
In an application with some sulfonylureas may increase hypoglycemic effect which is associated with an increased concentration of free fraction of co-trimoxazole.
The simultaneous use of co-trimoxazole and methotrexate may increase the toxicity of the latter (in particular to the appearance of pancytopenia) due to its release from binding to plasma proteins.
Influenced butadion, indomethacin, naproxen, salicylates and other NSAIDs may increase the action co-trimoxazole with the development of undesirable effects, since there release of active substances from binding with blood proteins and increase their concentration.
Simultaneous treatment with diuretics and co-trimoxazole increases the risk of thrombocytopenia caused by the latter especially in elderly patients.
In the case of co-administration chloridine with Sulphamethoxazole/trimethoprim antimicrobial effect is enhanced because chloridine inhibits the formation of tetrahydrofolic acid required for the synthesis of nucleic acids and proteins. In turn sulfonamides inhibit the formation of dihydrofolic acid, a precursor of tetrahydrofolic acid. This combination is widely used in the treatment of toxoplasmosis.
Absorption of sulfamethoxazole and trimethoprim at their joint reception with cholestyramine decreases the formation of insoluble complexes, which leads to a decrease in their concentration in the blood.
Sulphamethoxazole/trimethoprim side effects
Digestive system: nausea, vomiting, diarrhea, glossitis, pseudomembranous colitis, cholestatic hepatitis.
Allergic reactions: skin rash, angioedema, Stevens-Johnson syndrome, Lyell's syndrome.
Hemopoietic system: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia.
Urinary system: crystalluria, hematuria, interstitial nephritis.
Local reactions: phlebitis (when IV injected).
Other: purpura, impaired thyroid function.
Sulphamethoxazole/trimethoprim contraindications
Expressed disorders of liver and kidney function, blood diseases, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation (breastfeeding), hypersensitivity to sulfonamides and trimethoprim.
Active ingredient matches for Sulphamethoxazole/trimethoprim:
Sulphamethoxazole/trimethoprim
List of Sulphamethoxazole/trimethoprim substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| MOUNTRIM (India) | |
| Mountrim Sulphamethoxazole 800 mg, Trimethoprim 160 mg. DISPERTAB / 10 (Mount Mettur) | $ 0.22 |
| Mountrim Sulphamethoxazole 200 mg, Trimethoprim 40 mg. SUSP / 50ml (Mount Mettur) | $ 0.11 |
| MOUNTRIM tab 10's (Mount Mettur) | $ 0.10 |
| MOUNTRIM dispertab 10's (Mount Mettur) | $ 0.22 |
| MOUNTRIM oral susp 50ml (Mount Mettur) | $ 0.11 |
| Mountrim Sulphamethoxazole 400 mg, Trimethoprim 80 mg. TAB / 10 (Mount Mettur) | $ 0.10 |
| Mountrim Sulphamethoxazole 800 mg, Trimethoprim 160 mg. DISPERTAB / 10 (Mount Mettur) | $ 0.22 |
| Mountrim Sulphamethoxazole 200 mg, Trimethoprim 40 mg. SUSP / 50ml (Mount Mettur) | $ 0.11 |
| ORIPRIM TAB (India) | |
| 10's (Zydus Cadila) | $ 0.09 |
| Oriprim Tab Sulphamethoxazole 800 mg, Trimethoprim 160 mg. TAB / 10 (Zydus Cadila) | $ 0.13 |
| Oriprim Tab Sulphamethoxazole 400 mg, Trimethoprim 80 mg. TAB / 10 (Zydus Cadila) | $ 0.09 |
| ORIPRIM TAB tab 10's (Zydus Cadila) | $ 0.09 |
| Oriprim Tab Sulphamethoxazole 800 mg, Trimethoprim 160 mg. TAB / 10 (Zydus Cadila) | $ 0.13 |
| Oriprim Tab Sulphamethoxazole 400 mg, Trimethoprim 80 mg. TAB / 10 (Zydus Cadila) | $ 0.09 |
| Primzole (Singapore) | |
| Primzole 1's | |
| SUMETROL (India) | |
| 10's (Themis Chemicals Ltd.) | $ 0.15 |
| 50ml (Themis Chemicals Ltd.) | $ 0.10 |
| Sumetrol 400+80 Tablet (Themis Chemicals Ltd.) | $ 0.01 |
| Sumetrol 50 ml Suspension (Themis Chemicals Ltd.) | $ 0.01 |
| Sumetrol Trimethoprim 80 mg, Sulphamethoxazole 400 mg. TAB / 10 (Themis Chemicals Ltd.) | $ 0.08 |
| Sumetrol Trimethoprim 160 mg, Sulphamethoxazole 800 mg. DS-TAB / 10 (Themis Chemicals Ltd.) | $ 0.15 |
| Sumetrol Trimethoprim 40 mg, Sulphamethoxazole 200 mg/5 mL. SUSP / 50ml (Themis Chemicals Ltd.) | $ 0.10 |
| SUMETROL tab 10's (Themis Chemicals Ltd.) | $ 0.08 |
| SUMETROL oral susp 50ml (Themis Chemicals Ltd.) | $ 0.10 |
| Sumetrol Trimethoprim 80 mg, Sulphamethoxazole 400 mg. TAB / 10 (Themis Chemicals Ltd.) | $ 0.08 |
| Sumetrol Trimethoprim 160 mg, Sulphamethoxazole 800 mg. DS-TAB / 10 (Themis Chemicals Ltd.) | $ 0.15 |
| Sumetrol Trimethoprim 40 mg, Sulphamethoxazole 200 mg/5 mL. SUSP / 50ml (Themis Chemicals Ltd.) | $ 0.10 |
| TABROL-DS (India) | |
| TABROL-DS tab 10's (Aristo) | $ 0.13 |
| TPRIM (India) | |
| 10's (Alkem) | $ 0.21 |
| 60ml (Alkem) | $ 0.15 |
| Tprim Trimethoprim 160 mg, sulphamethoxazole 800 mg. TAB / 10 (Alkem) | $ 0.21 |
| Tprim Trimethoprim 40 mg, sulphamethoxazole 200 mg/5 mL. SUSP / 60ml (Alkem) | $ 0.15 |
| TPRIM tab 10's (Alkem) | $ 0.21 |
| TPRIM oral susp 60ml (Alkem) | $ 0.15 |
| Tprim Trimethoprim 160 mg, sulphamethoxazole 800 mg. TAB / 10 (Alkem) | $ 0.21 |
| Tprim Trimethoprim 40 mg, sulphamethoxazole 200 mg/5 mL. SUSP / 60ml (Alkem) | $ 0.15 |
| TRIMZOLE DS (India) | |
| 200's (Laborate Pharmaceuticals India Ltd.) | $ 2.87 |
| Trimzole DS 800+160 Tablet (Laborate Pharmaceuticals India Ltd.) | $ 0.01 |
| Trimzole DS Trimethoprim 160 mg, Sulphamethoxazole 800 mg. TAB / 200 (Laborate Pharmaceuticals India Ltd.) | $ 2.87 |
| TRIMZOLE DS tab 10's (Laborate Pharmaceuticals India Ltd.) | $ 0.14 |
| Trimzole DS Trimethoprim 160 mg, Sulphamethoxazole 800 mg. TAB / 200 (Laborate Pharmaceuticals India Ltd.) | $ 2.87 |
See 63 substitutes for Sulphamethoxazole/trimethoprim | |
References
- DailyMed. "POLYMYXIN B SULFATE; TRIMETHOPRIM SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "trimethoprim". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "trimethoprim". http://www.drugbank.ca/drugs/DB00440 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
