What happens if I overdose Symax FasTab?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, dizziness, headache, nausea, or vomiting; trouble breathing or swallowing.
Proper storage of Symax FasTab orally disintegrating tablets:
Store Symax FasTab orally disintegrating tablets at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Symax FasTab orally disintegrating tablets out of the reach of children and away from pets.
Overdose of Symax FasTab in details
The signs and symptoms of overdose are headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation.
Measures to be taken are immediate lavage of the stomach and injection of physostigmine 0.5 to 2 mg intravenously and repeated as necessary up to a total of 5 mg. Fever may be treated symptomatically (tepid water sponge baths, hypothermic blanket). Excitement to a degree which demands attention may be managed with sodium thiopental 2% solution given slowly intravenously or chloral hydrate (100-200 mL of a 2% solution) by rectal infusion. In the event of progression of the curare-like effect to paralysis of the respiratory muscles, artificial respiration should be instituted and maintained until effective respiratory action returns.
In rats, the LD for Symax FasTab is 375 mg/kg. Symax FasTab® (Symax FasTab) is dialyzable.
What should I avoid while taking Symax FasTab?
Avoid taking antacids at the same time you take Symax FasTab. Antacids can make it harder for your body to absorb Symax FasTab. If you use an antacid, take it after you have taken Symax FasTab and eaten a meal.
Symax FasTab may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Drinking alcohol can increase drowsiness and dizziness while you are taking Symax FasTab.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Symax FasTab can decrease sweating and you may be more prone to heat stroke.
Symax FasTab warnings
In the presence of high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating). Diarrhea may be an early symptom of incomplete intestinal obstruction especially in patients with ileostomy or colostomy. In this instance, treatment with this drug would be inappropriate and possibly harmful. Like other anticholinergic agents, Symax FasTab® (Symax FasTab) may produce drowsiness, dizziness or blurred vision. In this event, the patient should be warned not to engage in activities requiring mental alertness such as operating a motor vehicle or other machinery or to perform hazardous work while taking this drug.
Psychosis has been reported in sensitive individuals given anticholinergic drugs including Symax FasTab sulfate. CNS signs and symptoms include confusion, disorientation, short-term memory loss, hallucinations, dysarthria, ataxia, euphoria, anxiety, fatigue, insomnia, agitation and mannerisms, and inappropriate affect. These CNS signs and symptoms usually resolve within 12 to 48 hours after discontinuation of the drug.
What should I discuss with my healthcare provider before taking Symax FasTab?
Some medical conditions may interact with Symax FasTab drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have nerve problems, prostate problems, esophagus problems (eg, reflux), stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
- if you have diarrhea or fever, have been very ill, or are in poor health
Some MEDICINES MAY INTERACT with Symax FasTab drops. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Symax FasTab drops's side effects
- Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Symax FasTab drops
- Ketoconazole or metoclopramide because their effectiveness may be decreased by Symax FasTab drops
This may not be a complete list of all interactions that may occur. Ask your health care provider if Symax FasTab drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Symax FasTab precautions
General
Use with caution in patients with: autonomic neuropathy, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac arrhythmias, hypertension, and renal disease. Investigate any tachycardia before giving any anticholinergic drug since they may increase the heart rate. Use with caution in patients with hiatal hernia associated with reflux esophagitis.
Carcinogenesis, Mutagenesis, Impairment of Fertility
No long-term studies in animals have been performed to determine the carcinogenic, mutagenic or impairment of fertility potential of Symax FasTab® (Symax FasTab); however, 40 years of marketing experience with Symax FasTab sulfate shows no demonstrable evidence of a problem.
Pregnancy–Pregnancy Category C
Animal reproduction studies have not been conducted with Symax FasTab® (Symax FasTab). It is also not known whether Symax FasTab® (Symax FasTab) can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Symax FasTab® (Symax FasTab) should be given to a pregnant woman only if clearly needed.
Nursing Mothers
Symax FasTab® (Symax FasTab) is excreted in human milk. Caution should be exercised when Symax FasTab® (Symax FasTab) is administered to a nursing woman.
Geriatric Use
Reported clinical experience has not identified differences in safety between patients aged 65 and over and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
What happens if I miss a dose of Symax FasTab?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DrugBank. "hyoscyamine". http://www.drugbank.ca/drugs/DB00424 (accessed September 17, 2018).
- MeSH. "Parasympatholytics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
- Safe Work Australia - HCIS. "hyoscyamine: The Hazardous Chemical Information System (HCIS) at the Safe Work Australia is a database of chemical classifications and workplace exposure standards. It allows users to find information on chemicals that have been classified in accordance with the GHS or which have an Australian Workplace Exposure Standard.". http://hcis.safeworkaustralia.gov.au... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
