What is Syn MD?
Preventing infection during prostate surgery or other urinary tract surgeries. It may also be used for other conditions as determined by your doctor.
Syn MD irrigation solution is a hexitol irrigant. It works by flushing debris out of the surgical area to help prevent infection.
Syn MD indications
It has been employed as a 30% solution as an alternative to glucose in parenteral nutrition but its use is not recommended because of the risk of lactic acidosis.
Syn MD may be administered by mouth or rectally as an osmotic laxative in the management of constipation doses of 20 to 50 g have been suggested.
Solutions containing about 3% of Syn MD are used as irrigating fluids in transurethral surgical procedures.
Syn MD also acts as a bulk sweetening agent. It is used in limited quantities as a sweetener in energy-reduced diabetic food products. It is also used as an alternative to sucrose in many sugar-free oral liquid preparations and in sugar-free foods as it is less likely to cause dental caries.
Syn MD also has humectant and stabilising properties and is used in various pharmaceutical and cosmetic products including toothpaste.
How should I use Syn MD?
Use Syn MD solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Syn MD solution may be taken with or without food.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Do not take additional laxatives or stool softeners while taking Syn MD solution unless directed by your doctor.
- If you are using Syn MD solution as a rectal enema, follow the directions given with the enema. Ask your doctor or pharmacist any questions you may have about giving an enema.
- Do not exceed the recommended dose or use Syn MD solution for longer than 1 week without checking with your doctor.
- If you miss a dose of Syn MD solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Syn MD solution.
Uses of Syn MD in details
Syn MD is used to treat occasional constipation.
Syn MD description
A polyhydric alcohol with about half the sweetness of sucrose. Syn MD occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures.
Syn MD dosage
Syn MD Dosage
Applies to the following strength(s): 70%; 3.3%; 3%
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Constipation
Usual Pediatric Dose for:
- Constipation
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
Usual Adult Dose for Constipation
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Usual Pediatric Dose for Constipation
2 to 11 years:
Oral: 2 mL/kg (70% solution) once.
Rectal: 30 to 60 mL (25% to 30% solution) as a rectal enema once.
Greater than or equal to 12 years:
Oral: 30 to 150 mL (70% solution) once.
Rectal: 120 mL (25% to 30% solution) as a rectal enema once.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The use of Syn MD is contraindicated in patients with anuria. Syn MD should not be used in patients with suspected or documented fructose intolerance. Syn MD should not given by injection.
Sudden severe abdominal bloating and diarrhea have been reported in patients ingesting Syn MD.
Solutions for urologic irrigation should be used with caution in patients with severe cardiopulmonary or renal dysfunction.
Irrigating fluids used during transurethral prostatectomy have been demonstrated to enter the systemic circulation in relatively large volumes; thus Syn MD irrigating solution must be regarded as a systemic agent. Absorption of large amounts of fluids containing Syn MD may significantly alter cardiopulmonary and renal dynamics. Appropriate patient monitoring should be conducted due to the possibility of fluid overload. If fluid overload occurs, intensive fluid and electrolyte management should be initiated. Monitoring of fluid and electrolyte levels beyond the acute phase may be necessary due to the possibility of delayed fluid absorption.
Hyperglycemia from metabolism of absorbed Syn MD may be observed in patients with diabetes mellitus.
The cardiovascular status, especially of the patient with cardiac disease, should be carefully monitored before and during transurethral resection of the prostate when using 3% Syn MD urologic irrigating solution, because the quantity of fluid absorbed into the systemic circulation by opened prostatic veins may produce significant expansion of the intravascular fluid and lead to fulminating congestive heart failure.
Shift of sodium free intracellular fluid into the extracellular compartment, following systemic absorption could lower serum concentration and aggravate preexisting hyponatremia.
Excessive loss of water and electrolytes may lead to serious imbalances. With continuous use of solution, loss of water may occur in excess of electrolytes, producing hypernatremia.
Sustained diuresis that results from transurethral irrigation with Syn MD irrigating solutions could obscure and intensify inadequate hydration or hypovolemia.
Dialysis
Data not available
More about Syn MD
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Espanol
- 1 Review - Add your own review/rating
Consumer resources
- Syn MD solution
- Syn MD
Related treatment guides
- Constipation
Syn MD interactions
See also:
What other drugs will affect Syn MD?
Calcium Polystyrene Sulfonate: Syn MD may enhance the adverse/toxic effect of Calcium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
LamiVUDine: Syn MD may decrease the serum concentration of LamiVUDine. Management: When possible, avoid chronic coadministration of Syn MD-containing solutions with lamivudine, but if this combination cannot be avoided, monitor patients more closely for possible therapeutic failure associated with decreased lamivudine exposure. Consider therapy modification
Sodium Polystyrene Sulfonate: Syn MD may enhance the adverse/toxic effect of Sodium Polystyrene Sulfonate. More specifically, concomitant use of these agents may increase the risk for intestinal necrosis. Avoid combination
Syn MD side effects
See also:
What are the possible side effects of Syn MD?
Life threatening adverse reactions with intravenous Syn MD infusions have been reported in patients with fructose intolerance.
The literature reports occasional adverse reactions for intravenous Syn MD infusions. These include disturbances such as acidosis, electrolyte loss, marked diuresis, urinary retention, edema, dryness of mouth and thirst, and dehydration; cardiovascular/pulmonary disorders such as pulmonary congestion, hypotension, tachycardia, angina-like pains, and other general reactions such as blurred vision, convulsions, nausea, vomiting, diarrhea, rhinitis, chills, vertigo, and backache. Allergic reactions reported to occur from Syn MD include urticaria.
Should adverse reactions occur, discontinue the irrigant and reevaluate the clinical status of the patient.
Post-Marketing Experience
Following off-label use of 3% Syn MD Urologic Irrigating Solution for hysteroscopic procedures in women, life-threatening adverse events related to fluid overload have been reported.
Syn MD contraindications
See also:
What is the most important information I should know about Syn MD?
Syn MD should not be given to patients with hereditary fructose intolerance. It should be given with caution to patients with impaired kidney function or severe liver damage.
Active ingredient matches for Syn MD:
Sorbitol in Switzerland.
List of Syn MD substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Sorbitol Bidiphar (Vietnam) | |
| Sorbitol Bidiphar 5 g x 25 Packs | |
| Sorbitol Corsa (Indonesia) | |
| Sorbitol Corsa/Sanofi-Synthelabo (Indonesia) | |
| Sorbitol Corsa/Sanofi-Synthelabo 5 g x 20's (Sanofi-Synthelabo) | $ 2.25 |
| Sorbitol Danapha (Vietnam) | |
| Sorbitol Danapha 5 g x 20 Packs | |
| Sorbitol Delalande (Belgium, France, Luxembourg, Vietnam) | |
| Sorbitol Delalande 5 g x 20 Packs | |
| Sorbitol Delalande 5g (Luxembourg) | |
| Sorbitol Domesco (Vietnam) | |
| Sorbitol DOMESCO 5 g x 20 Packs | |
| Sorbitol DOMESCO 5 g x 25 Packs | |
| Sorbitol Donaipharm (Vietnam) | |
| Sorbitol Donaipharm 5 g x 20 Packs x 5 g | |
| Sorbitol F | |
| Sorbitol FP | |
| Sorbitol Glomed (Vietnam) | |
| Sorbitol Glomed 5 g x 20 Packs | |
| Sorbitol Hypertonique Biosedra | |
| Injectable; Injection; Sorbitol 10% | |
| Sorbitol in plastic container | |
| Solution; Irrigation; Sorbitol 3.3 g / 100 ml | |
| Solution; Irrigation; Sorbitol 3 g / 100 ml | |
| Sorbitol Infomed (Romania) | |
| Sorbitol Irrigation Solution | |
| Sorbitol Mebiphar (Vietnam) | |
| Sorbitol Mebiphar 5 g x 20 g | |
| Sorbitol Mipharmco (Vietnam) | |
| Sorbitol Mipharmco 20 Packs x 5 g | |
| Sorbitol Mipharmco 25 Packs x 5 g | |
| Sorbitol Phapharco (Vietnam) | |
| Sorbitol Phapharco 5 g x 25 Packs x 5 g | |
| Sorbitol Richard (France) | |
| Sorbitol Sanofi (Vietnam) | |
| Sorbitol Sanofi 5 g x 25 Packs | |
| Sorbitol Solution | |
| Sorbitol Stada (Vietnam) | |
| Sorbitol Stada 5 g x 20 Packs x 5 g | |
| Sorbitol Synth (Egypt) | |
| Sorbitol Vidipha (Vietnam) | |
| Sorbitol Vidipha 5 g x 25 Packs | |
| Sorbitol, liquid (crystallising) ph eur | |
| Sorbitol, liquid (non-crystallising) ph eur | |
| Sorbitol, liquid, partially dehydrated ph eur | |
| Sorbitol-Infusionslösung (Germany) | |
| Sorbitur (Sweden) | |
| Sorbosan (Ethiopia) | |
| Sorbostyl (France) | |
| Synolis V-A (Peru) | |
| Szorbit (Hungary) | |
| Tendisorbitol (Vietnam) | |
| Tendisorbitol 5 g x 20 Packs | |
| Theo Salhexin Oral | |
| Theo Salhexin Oral 100 ml Syrup (Duckbill Drugs Pvt Ltd) | $ 0.03 |
| Tricholiv | |
| Tricholiv 200 ml Syrup (Oyster Labs Limited) | $ 0.04 |
| Uromatic S (Japan) | |
| Uromatic S 3% (Japan) | |
See 106 substitutes for Syn MD | |
Reviews
The results of a survey conducted on ndrugs.com for Syn MD are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Syn MD. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
