Dosage of Targifor in details
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution,
Intravenous, as hydrochloride [preservative free]:
R-Gene 10: 10% (300 mL) [latex free]
Dosing: Adult
Diagnostic aid (pituitary function): Note: Dosing based on Targifor hydrochloride product. IV: 30 g as a single dose
Hyperammonemia, acute (urea cycle disorders) (off-label use): Note: Dosing based on Targifor hydrochloride product and on specific enzyme deficiency. Therapy should continue until ammonia levels are in normal range. If a loading dose is used, it should not be repeated. Targifor dose may be adjusted downward if patient becomes hypotensive and/or when the exact enzyme deficiency is identified. Administer concomitantly with sodium benzoate and sodium phenylacetate along with dialysis (NORD 2012).
Weight-directed dosing:
Argininosuccinate synthetase (ASS, Citrullinemia) or Argininosuccinate lyase (ASL) deficiency: IV: Loading dose: 600 mg/kg followed by a continuous IV infusion of 600 mg/kg/day (NORD 2012)
Carbamyl phosphate synthetase (CPS), ornithine transcarbamylase (OTC) or N-acetylglutamate synthetase (NAGS) deficiency: IV: Loading dose: 200 mg/kg followed by a continuous IV infusion of 200 mg/kg/day (NORD 2012)
Unconfirmed/pending diagnosis: IV: Loading dose: 600 mg/kg followed by a continuous IV infusion of 600 mg/kg/day (NORD 2012); if ASS and ASL are excluded as diagnostic possibilities, reduce dose to 200 mg/kg/day
BSA-directed dosing:
Argininosuccinate synthetase (ASS, Citrullinemia) or Argininosuccinate lyase (ASL) deficiency: IV: Loading dose: 12 g/m/day in 3 to 4 divided doses
Targifor interactions
Cyclosporine - L-Targifor may counteract the antinaturetic effect of cyclosporin. Ibuprofen - L-Targifor may increase the absorption of ibuprofen if taken concomitantly. Organic nitrates - L-Targifor supplements theoretically may potentiate the effects of organic nitrates if taken concomitantly. Sildenafil citrate - Theoretically, L-Targifor supplements taken concomitantly with sildenafil citrate, may potentiate the effects of the drug.
Reviews
The results of a survey conducted on ndrugs.com for Targifor are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Targifor. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
No survey data has been collected yetConsumer reported doses
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Information checked by Dr. Sachin Kumar, MD Pharmacology
