Terpect Tab Tablet Dosage

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Dosage of Terpect Tab Tablet in details

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Terpect Tab Tablet Dosage

Applies to the following strength(s): 2.5 mg; 5 mg; 0.2 mg/inh; 1 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Asthma - Maintenance

Tablets: 5 mg orally 3 times a day at 6 hour intervals during waking hours. May decrease to 2.5 mg/dose if side effects are pronounced. Do not exceed 15 mg in 24 hours.

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Usual Adult Dose for Premature Labor

Tablets: 2.5 to 7.5 mg orally every 6 hours. Therapy should be continued until 36 to 37 weeks gestation.

Continuous intravenous infusion: 10 to 25 mcg/min. Therapy should be continued until labor has been arrested. Maximum dose 80 mcg/min.

Subcutaneous injection: 0.25 mg every 6 hours. Subcutaneous therapy should be continued until labor has been arrested.

Usual Adult Dose for Asthma - Acute

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Subcutaneous Injection: 0.25 mg into the lateral deltoid area. A second 0.25 mg dose can be administered in 15 to 30 minutes if needed. Do not exceed 0.5 mg in 4 hours.

Continuous intravenous infusion: 0.08 to 6 mcg/kg/min.

Usual Pediatric Dose for Asthma - Acute

Subcutaneous Injection: 0.005 to 0.01 mg/kg/dose to a maximum dose of 0.4 mg every 15 to 20 minutes for 2 doses.

Nebulization: 0.01 to 0.03 mg/kg/dose with a minimum dose of 0.1 mg; maximum dose is 2.5 mg diluted with 1 to 2 mL of normal saline every 4 to 6 hours.

Continuous intravenous infusion: 0.08 to 6 mcg/kg/min.

> 12 years:

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

Subcutaneous Injection: 0.25 mg into the lateral deltoid area. A second 0.25 mg dose can be administered in 15-30 minutes if needed. Maximum dose 0.5 mg in 4 hours.

Usual Pediatric Dose for Asthma - Maintenance

< 12 years:

Tablets: 0.05 mg/kg/day divided into three doses. Gradually increase to 0.15 mg/kg/day. Maximum dose is 5 mg per day.

>=12 years:

Inhalation aerosol: 2 inhalations separated by 60 seconds every 4 to 6 hours. Do not repeat more often than every 4 to 6 hours.

>=12 <15 years:

Tablets: 2.5 mg orally every 6 to 8 hours. Do not exceed 7.5 mg in 24 hours

>=15 years:

Tablets: 2.5 mg to 5 mg orally every 6 to 8 hours. Do not exceed 15 mg in 24 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Terpect Tab Tablet is not approved by the FDA for use as a tocolytic agent. Although Terpect Tab Tablet and other beta-agonists have been shown to be effective in arresting episodes of premature labor, there are few studies which evaluate its use for maintenance therapy after successful treatment of an episode of premature labor. A meta-analysis of those few studies did not support its use for maintenance therapy.

Dialysis

Data not available

More about Terpect Tab Tablet

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What other drugs will affect Terpect Tab Tablet?

You should not take Terpect Tab Tablet if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Terpect Tab Tablet, especially:

This list is not complete. Other drugs may interact with Terpect Tab Tablet, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Terpect Tab Tablet interactions

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Drug Interactions

The concomitant use of Terpect Tab Tablet with other sympathomimetic agents is not recommended, since the combined effect on the cardiovascular system may be deleterious to the patient

Monoamine Oxidase Inhibitors or Tricyclic Antidepressants: Terpect Tab Tablet should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, since the action of Terpect Tab Tablet on the vascular system may be potentiated

Beta-Blockers Beta-adrenergic receptor blocking agents not only block the pulmonary effect of beta-agonists, such as Terpect Tab Tablet, but may produce severe bronchospasm in asthmatic patients. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, e.g., as prophylaxis after myocardial infarction, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution

Diuretics The ECG changes and/or hypokalemia that may result from the administration of nonpotassium-sparing diuretics (such as loop or thiazide diuretics) can be acutely worsened by beta-agonists, especially when the recommended dose of the beta-agonist is exceeded. Although the clinical significance of these effects is not known, caution is advised in the coadministration of beta-agonists with nonpotassium-sparing diuretics.


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References

  1. DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. MeSH. "Tocolytic Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "terbutaline: The European Chemicals Agency (ECHA) is an agency of the European Union which is the driving force among regulatory authorities in implementing the EU's groundbreaking chemicals legislation for the benefit of human health and the environment as well as for innovation and competitiveness.". https://echa.europa.eu/ (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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