Terpect Tablet Uses

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Terpect Tablet indications

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Terpect Tablet hydrochloride SYRUP indicated for cough associated with wheeziness (bronchospasm) and tenacious phlegm (sputum).

Uses of Terpect Tablet in details

Terpect Tablet is used to treat breathing difficulties caused by excessive mucus secretions in the air passages associated with respiratory tract infections.

Terpect Tablet description

Each tablet also contains lactose, maize or potato starch, gelatine and magnesium stearate as excipients.

The oral/inhalation solution also contains tartaric acid and methyl parahydroxybenzoate as excipients.

The syrup also contains tartaric acid, benzoic acid, sodium carboxymethylcellulose, glycerol, sorbitol solution, pharma flavor and ethanol as excipients.

Each capsule also contains lactose, cornstarch and magnesium stearate as excipients.

Terpect Tablet HCl is N-cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)amine hydrochloride.

Terpect Tablet dosage

Unless otherwise prescribed, the following doses are recommended:

Tablet: Adults and Children >12 years: 8 mg (1 tab) thrice daily; 6-12 years: 4 mg (½ tab) thrice daily; 2-6 years: 4 mg (½ tab) twice daily.

Oral Solution:

Adults and Children >12 years: 4 mL thrice daily; 6-12 years: 2 mL thrice daily; 2-6 years: 20 drops thrice daily; <2 years: 10 drops thrice daily.

Inhalation Solution (with aerosol apparatus): It is generally recommended to warm inhalation solution to body temperature before inhalation. Patients with bronchial asthma may be advised to commencing inhalation after they have taken their regular bronchospasmolytic therapy.

Adults: 4 mL. Children >12 years: 2 mL; 6-12 years: 1 mL; 2-6 years: 10 drops; <2 years: 5 drops. All doses to be taken twice daily.

The solution may be diluted 1:1 in physiological saline solution. In order to avoid precipitation, the solution should be inhaled immediately after mixing. The combined administration of inhalation and oral application intensifies the effect, and is especially suited for the commencement of treatment in cases where the full effect is to be reached quickly.

Syrup: Adults and Children >12 years: 5 ml (1 tsp) thrice daily.

At commencement of treatment, it may be necessary to increase the total daily dose up to 48 mg in adults.

The syrup is sugar-free and therefore suitable for diabetics and small children.

Ampoule: Severe cases, before and after surgical intervention: 1 amp SC, IM or IV (duration of injection: 2-3 min) 2-3 times daily.

Capsule: Adults: 1 cap 3 times daily.

It is recommended for the initial phase of treatment usually lasting not more than a week.

Patients being treated with Terpect Tablet should be notified of an expected increase in the flow of secretions.

Terpect Tablet interactions

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A reduction in dose of cardiac glycosides (e.g. digitalis) and quinidine might become necessary in patients suffering from congestive cardiac failure because of the positive inotropic effect of orciprenaline sulphate.

Terpect Tablet hydrochloride SYRUP should not be administered concomitantly with beta-blocking agents, due to orciprenaline’s reversal of anti-hypertensive action.

The concomitant use of other sympathomimetic agents should be carefully controlled to avoid potentiation of effects.

Terpect Tablet side effects

Terpect Tablet’s pharmacological action may lead to gastric irritation. A transient rise in serum aminotransferase values have been reported due to Terpect Tablet.

Orciprenaline sulphate, as a sympathomimetic agent, may precipitate a wide range of adverse effects. Side-effects include fear; anxiety, restlessness, tremor, insomnia, confusion, irritability, weakness and psychotic states. Appetite may be reduced and nausea and vomiting may occur. A rise in blood pressure which may produce cerebral haemorrhage and pulmonary oedema, tachycardia and cardiac arrhythmias, anginal pain, palpitations, and cardiac arrest. Hypotension with dizziness and fainting and flushing may occur. Other effects that may occur include difficulty in micturition and urinary retention; dyspnoea; weakness; headache; disturbances of glucose metabolism; sweating and hypersalivation. Muscle cramps or twitching or unpleasant taste may occur.

Terpect Tablet contraindications

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Terpect Tablet hydrochloride SYRUP is contra-indicated in patients with known hypersensitivity to sympathomimetic amines or any of the other ingredients; hypertrophic obstructive cardiomyopathy; and tachyarrhythmia.

Sympathomimetics, such as orciprenaline sulphate, may interact with monoamine oxidase inhibitors (MAOI), and therefore Terpect Tablet hydrochloride SYRUP should not be given to patients receiving such treatment or within 14 days of MAOI treatment termination.

Safety in pregnancy and lactation has not been established.

Active ingredient matches for Terpect Tablet:

Bromhexine

Guaifenesin/Terbutaline


Unit description / dosage (Manufacturer)Price, USD
Terpect Tablet$ 0.03

List of Terpect Tablet substitutes (brand and generic names):

TERLINE syr 100ml (Pure Win Labs Pvt. Ltd.)$ 0.48
Solution; Oral; Bromhexine Hydrochloride 4 mg / 5 ml (Novartis)
Solution; Oral; Bromhexine Hydrochloride 8 mg / 5 ml (Novartis)
THEOSAL PD SYRUP 1 bottle / 100 ML syrup each (Monichem Healthcare Pvt Ltd)$ 0.63
Thephidron 8 mg x 200's (Combiphar)$ 2.88
Tolbin Expectorant 100 mL
Topcure 170 ml Syrup (Serve Pharmaceuticals)$ 0.02
Topcure 100 ml Syrup (Serve Pharmaceuticals)$ 0.02
Topcure 60 ml Syrup (Serve Pharmaceuticals)$ 0.02
Torex BR 100 ml Syrup (Torque Pharmaceuticals Pvt. Ltd.)$ 0.03
Torex BR 50 ml Syrup (Torque Pharmaceuticals Pvt. Ltd.)$ 0.03
Torex BR Syrup (Torque Pharmaceuticals Pvt. Ltd.)$ 0.21
Torex Tablet (Torque Pharmaceuticals Pvt. Ltd.)$ 0.04
Torlin BR 60 ml Syrup (Laborate Pharmaceuticals India Ltd.)$ 0.03
Torlin BR 100 ml Syrup (Laborate Pharmaceuticals India Ltd.)$ 0.03
TORLIN BR 100MG/8MG/2.5MG SYRUP 1 bottle / 60 ML syrup each (Laborate Pharmaceuticals India Ltd.)$ 0.14
TORLIN BR 50MG/1.25MG/4MG SYRUP 1 bottle / 100 ML syrup each (Laborate Pharmaceuticals India Ltd.)$ 0.20
Torlin BR 100 mg/8 mg/2.5 mg Syrup (Laborate Pharmaceuticals India Ltd.)$ 0.14
Torlin BR 50 mg/1.25 mg/4 mg Syrup (Laborate Pharmaceuticals India Ltd.)$ 0.20
Torlin-BR Bromhexine hydrochloride 8 mg, Terbutaline sulphate 2.5 mg, Guaiphenesin 100 mg, Menthol0.5 mg. SYR / 100ml (Laborate)$ 0.54
Torlin-BR Bromhexine hydrochloride 8 mg, Terbutaline sulphate 2.5 mg, Guaiphenesin 100 mg, Menthol0.5 mg. SYR / 60ml (Laborate)$ 0.35
100ml (Laborate)$ 0.54
60ml (Laborate)$ 0.35
TORLIN-BR syr 100ml (Laborate)$ 0.54
TORLIN-BR syr 60ml (Laborate)$ 0.35
Toscof Expectorant 100 ml Expectorant (Cipla Limited)$ 0.02
Traxine DX 100 ml Syrup (Technica Labs & Pharma Pvt Ltd)$ 0.03
Traxine-DX Dextromethorphan hydrobromide5 mg, Bromhexine hydrochloride4 mg, Chlorpheniramine maleate2 mg. SYR / 100ml (Technica Labs)$ 0.54
100ml (Technica Labs)$ 0.54
TRAXINE-DX syr 100ml (Technica Labs)$ 0.54

References

  1. DailyMed. "TERBUTALINE SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "GUAIFENESIN; HYDROCODONE BITARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "terbutaline". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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