Consists of Dexamethasone, Neomycin, Tiabendazole
What is Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)?
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) intravitreal implant is used to treat an eye disease called macular edema (swelling of the back of the eye). Macular edema occurs when a blood vessel in the eye is clogged. This causes vision changes that must be treated right away. Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is a corticosteroid (steroid medicine) that helps reduce the swelling in the eye.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) intravitreal implant is also used to treat an eye disease called uveitis (swelling in the middle part of the eye). Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is also used to treat diabetic macular edema in patients with artificial lens implant or are scheduled for cataract surgery.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is to be given only by or under the supervision of your doctor.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) indications
Retinal Vein Occlusion
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)® (Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) intravitreal implant) is indicated for the treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO).
Posterior Segment Uveitis
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)® is indicated for the treatment of non-infectious uveitis affecting the posterior segment of the eye.
1.3 Diabetic Macular Edema
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)® is indicated for the treatment of diabetic macular edema.
How should I use Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)?
Use Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- If your doctor prescribed more than 1 eye medicine, find out the best order for using each medicine.
- Remove contact lenses before using Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
- Shake well before each use.
- To use Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
- To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
- If you miss a dose of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
Uses of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in details
This medication is used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. It is also used to test for an adrenal gland disorder (Cushing's syndrome). It decreases your body's natural defensive response and reduces symptoms such as swelling and allergic-type reactions. Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is a corticosteroid hormone (glucocorticoid). This injectable form of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is used when a similar drug cannot be taken by mouth or when a very fast response is needed, especially in patients with severe medical conditions. Talk to your doctor about the risks and benefits of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), especially if it is to be injected near your spine (epidural). Rare but serious side effects may occur with epidural use.
This drug may also be used with other medications as a replacement for certain hormones.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This drug may also be used to prevent nausea and vomiting caused by cancer chemotherapy.
How to use Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) injection
This medication is given by injection into a vein, muscle, joint, or skin wound as directed by your doctor. Follow your doctor's directions carefully. Dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often than prescribed without consulting your doctor. Some patients (especially newborns) should receive the preservative-free form of this drug. In these patients, when mixing this form of the drug, be sure to use IV fluid that is also preservative-free. Use these mixtures within 24 hours.
If this medication is injected into a joint, be careful how much pressure you put on that joint, even if it is feeling better. Ask your doctor how much you can move/use the joint while it is healing.
If you have been using this medication for a long time, do not suddenly stop using it without your doctor's approval. Your dose may need to be gradually decreased to reduce symptoms such as weakness, weight loss, nausea, or extreme tiredness.
If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
Tell your doctor if your condition persists or worsens.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) description
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is an intravitreal implant containing 0.7 mg (700 μg) Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in the Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) solid polymer drug delivery system. Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is preloaded into a single-use, specially designed DDS applicator to facilitate injection of the rod-shaped implant directly into the vitreous.
The Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) system contains poly (D,L-lactide-co-glycolide) PLGA intravitreal polymer matrix. Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is preservative-free. The chemical name for Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydoxy-16-methyl-,(11β, 16α). Its molecular weight is 392.47; molecular formula: C22H29FO3.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) occurs as a white to cream-colored crystalline powder having not more than a slight odor, and is practically insoluble in water and very soluble in alcohol.
The PLGA matrix slowly degrades to lactic acid and glycolic acid.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) dosage
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) Dosage
Generic name: Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) 20mg
Dosage form: tablets
Medically reviewed by Drugs.com. Last updated on Oct 17, 2019.
2.1 Recommended Dosage
The recommended dosage of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is 20 mg or 40 mg, orally, once daily, on specific days depending on the treatment regimen. Refer to the Prescribing Information of the other anti-myeloma products used in combination with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) for specific Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) dosing. Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) can be administered with or without food.
Dose Modification for Elderly Patients
Dose-reduction for Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is recommended for elderly patients, due to increased toxicity in these patients. Refer to the Prescribing Information of the other anti-myeloma products used as part of a combination regimen with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), for dosing recommendations in elderly patients.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Related questions
- Can I use expired neomycin and polymyxin b sulfates, Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) ophthalmic?
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More about Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney))
- Side Effects
- During Pregnancy or Breastfeeding
- Imprints, Shape & Color Data
- Drug Interactions
- Drug class: glucocorticoids
- FDA Alerts (7)
Consumer resources
Other brands: Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) Intensol, Dexasone, Baycadron,... +8 more
Professional resources
- Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (FDA)
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Related treatment guides
- Multiple Myeloma
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) interactions
Tablet/Forte Tablet: Barbiturates, Phenytoin, Ephedrine, Carbamazepine, Rifampicin and Other Drugs that Stimulate Hepatic Metabolism: May lessen the effect of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) due to enhancement of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) metabolism. Increase in Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) dosage may be required.
CYP3A4 Inhibitors eg, Ketoconazole and Macrolide Antibiotics: May increase plasma concentrations of corticosteroids.
Indinavir, Erythromycin and Other Drugs Metabolized by CYP3A4: Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is a moderate inducer of CYP3A4 and may increase clearance of these drugs, resulting in decreased plasma concentrations.
Oral Contraceptives and Estrogen:
Can cause alterations in plasma protein-binding and metabolism of corticosteroids which can result in exposure of women to increased levels of the unbound corticosteroid for long periods of time.Aspirin: Concomitant use of aspirin or other nonsteroidal anti-inflammatory agents (NSAIDs) and corticosteroids increases the risk of gastrointestinal adverse effects. Use aspirin cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Concomitant administration of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and aspirin may also cause changes in salicylate plasma protein-binding and its rate of metabolism. These changes cause lowering of plasma salicylate levels.
Warfarin: Co-administration of corticosteroids and warfarin usually results in decreased response to warfarin, although there have been conflicting results.
Monitor coagulation indices frequently to maintain the desired anticoagulant effect.
Potassium-Depleting Agents eg, Diuretics and Amphotericin-B: Observe patients closely for the development of hypokalemia. Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.
Anticholinesterase Agents: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, withdraw anticholinesterase agents at least 24 hrs before initiating corticosteroid therapy.
Antacids: Large doses of antacids cause alteration in corticosteroid absorption.
Insulin: Concomitant administration of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and insulin generally requires higher doses of insulin.
Ketoconazole: Decreases the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.
Thalidomide: Toxic epidermal necrolysis has been reported when Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) was used concomitantly with thalidomide.
Indomethacin: May cause false negative results in the Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) suppression test (DST).
Other Interactions: Toxoids and Live or Inactivated Vaccines: Patients on prolonged corticosteroid therapy may exhibit diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.
Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. If possible, postpone routine administration of vaccines or toxoids until corticosteroid therapy is discontinued.
Antidiabetic Agents: Dosage adjustment of antidiabetic agents may be required because corticosteroids may increase blood glucose concentrations.
Skin Tests: Corticosteroids may suppress reactions to skin tests.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) side effects
Clinical Studies Experience: Treatment of Macular Edema: Clinical Studies 206207‐008 and 206207‐009 (Initial 6‐month Treatment Period): The clinical safety of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) was assessed in 2 phase 3 randomized, double‐masked, sham-controlled studies in patients with macular edema following BRVO or CRVO. In both studies, a total of 421 patients were randomized and received Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and 423 received sham.
The most frequently reported adverse reactions considered to be related to the intravitreal injection procedure rather than the Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) implant, included vitreous hemorrhage and conjunctival edema.
Intraocular Pressure in the Initial 6‐month Treatment Period of Studies 008 and 009: See Table 4.
The proportion of patients with increases from baseline IOP ≥10 mmHg in the study eye was significantly greater with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) compared to sham at days 7, 30, 60, and 90. At day 180, there were no significant differences between Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and sham.
The proportion of patients experiencing increased IOP with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) peaked at day 60 and returned to baseline levels by day 180. Elevations of IOP either did not require treatment or were managed with topical IOP‐lowering medications in the vast majority of patients. During the initial treatment period, only 0.7% (3/421) of the patients who received Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) required laser or surgical procedures for management of elevated IOP in the study eye compared with 0.2% (1/423) with sham.
Systemic effects with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) would be expected to be negligible due to low systemic levels (below the lower level of quantitation). The adverse event profile for BRVO patients was generally similar to that observed for CRVO patients, and to the overall population. The overall incidence of adverse events was higher for the subgroup of patients with CRVO, which is consistent with the nature of the disease as patients with CRVO are more likely to develop ocular adverse events than patients with BRVO, even when not treated.
Clinical Studies 206207‐008 and 206207‐009 (6‐month Open‐label Extension): The clinical safety of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) was further assessed in a 6‐month open‐label (OL) extension of both phase 3 studies. Patients were eligible for re‐treatment if the BCVA was <84 letters or retinal thickness was >250 mcg in the central 1 mm macular subfield and the investigator considered that the procedure would not put the patient at significant risk. The re‐treated population consisted of patients who received Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), or sham as their 1st injection, completed the initial treatment period at day 180, and then received Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) as their 2nd injection. A total of 997 patients received the Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) injection in the open‐label phase of both studies.
For those events reported at a rate of ≥1%, the types of events and their incidence following the 2nd injection were similar to those seen following the 1st injection with the exception of subcapsular cataract which were higher in patients who had received Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) as their 1st injection followed by Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) as the 2nd injection. More specifically, subcapsular cataracts in the study eye were notably more common in the Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)/Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) group (12.9%) compared to either sham/Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (3.4%).
For events reported in ≤1% of patients, mostly in only 1 or 2 patients per group, some differences between the 1st and 2nd injection were seen. Review of these differences does not suggest a safety signal associated with repeat treatments.
The incidence of IOP increased was comparable between patients receiving either 1 or 2 doses of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
Treatment of Uveitis: Clinical Study 206207‐014: The clinical safety of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) was assessed in a multicenter, masked, and randomized, 26‐week phase 3 study in the treatment of non‐infectious uveitis affecting the posterior segment of the eye. A total of 76 patients were treated with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and 75 were treated with sham.
Intraocular Pressure in Study ‐014: As shown in Table 7, there were no clinically meaningful differences in the proportions of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and sham patients who experienced IOP at ≥25 mmHg or ≥35 mmHg in the study eye, at any visit. At week 26, no Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) patients and 3 sham patients had an IOP ≥25 mmHg; no patients had an IOP ≥35 mmHg.
Table 8 shows the proportion of patients with increases from baseline IOP ≥10 mmHg in the study eye was similar between Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) and sham, except at week 8 where significantly higher percentages were observed with Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (9.6%) compared to sham (0%), p=0.013. At week 26, only 1 Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) patient and 2 sham patients showed an increase from baseline IOP ≥10 mmHg.
The proportion of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)‐treated patients with increased IOP (≥25 mmHg) peaked at week 3 and returned to baseline by week 26. During the treatment period, no patients required incisional surgery for glaucoma. Three patients required laser iridotomies in the study eye for the treatment of pupillary block, iris bombe, and raised IOP.
Post-Marketing Experience: The following adverse reactions have been identified during post-marketing use of Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in clinical practice. Because post-marketing reporting of these reactions is voluntary and from a population of uncertain size, it is not always possible to reliably estimate the frequency of these reactions. The reactions have been chosen for inclusion due to a combination of the frequency of reporting and/or possible causal connection to Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
Eye Disorders: Endophthalmitis: Hypotony of eye (associated with vitreous leakage due to injection), retinal detachment.
General Disorders and Administration Site Conditions: Complication of device insertion (implant misplacement), device dislocation with or without corneal edema.
Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) contraindications
You should not use this medication if you are allergic to Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), or if you have a fungal infection anywhere in your body.
Before taking Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.
Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.
Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.
Do not receive a "live" vaccine while you are taking Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney). Vaccines may not work as well while you are taking a steroid.
Do not stop using Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
Wear a medical alert tag or carry an ID card stating that you take Dexamethasone (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney). Any medical care provider who treats you should know that you are using a steroid.
What is Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)?
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is an antibiotic that fights bacteria in the body.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is used to reduce the risk of infection during surgery of your intestines. Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is also used to reduce the symptoms of hepatic coma.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) may also be used for purposes not listed in this medication guide.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) tablets and other antibacterial drugs, Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Suppression of Intestinal Bacteria
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) tablets are indicated as adjunctive therapy as part of a regimen for the suppression of the normal bacterial flora of the bowel, e.g., preoperative preparation of the bowel. It is given concomitantly with erythromycin enteric-coated base.
Hepatic Coma (Portal-Systemic Encephalopathy)
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) has been shown to be effective adjunctive therapy in hepatic coma by reduction of the ammonia-forming bacteria in the intestinal tract. The subsequent reduction in blood ammonia has resulted in neurologic improvement.
How should I use Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)?
Use Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- Take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) with plenty of water to avoid dehydration.
- Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) on a regular schedule to get the most benefit from it.
- To clear up your infection completely, use Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) for the full course of treatment. Keep using it even if you feel better in a few days.
- If you miss a dose of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider.
Ask your health care provider any questions you may have about how to use Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
Uses of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in details
Oral Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is used before the operation of the gut to kill the bacteria which normally live in the gut that may cause a serious infection and in treatment of patients with coma due to liver disease (hepatic coma).
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) description
A component of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) dosage
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) Dosage
Generic name: Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) 87.5mg in 5mL
Dosage form: oral solution
See also:
- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment for periods longer than two weeks is not recommended.
Hepatic coma
For use as an adjunct in the management of hepatic coma, the recommended dose is 4 to 12 grams per day given in the following regimen:
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Withdraw protein from diet. Avoid use of diuretic agents.
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Give supportive therapy including blood products, as indicated.
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Give Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)
Oral Solution in doses of four to twelve grams of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) per day in divided doses.
Treatment should be continued over a period of five to six days during which time protein should be returned incrementally to the diet.
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If less potentially toxic drugs cannot be used for chronic hepatic insufficiency, Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in doses of up to four grams daily may be necessary. The risks for the development of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) induced toxicity progressively increase when the treatment must be extended to preserve the life of a patient with hepatic encephalopathy who has failed to fully respond. Frequent periodic monitoring of these patients to ascertain the presence of drug toxicity is mandatory. Also, Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) serum concentrations should be monitored to avoid potentially toxic levels. The benefits to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity and neuromuscular blockade following the accumulation of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in the tissues.
More about Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney))
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- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) solution
- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)
- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (Advanced Reading)
- Other brands: Neo-Tab
Professional resources
- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (FDA)
- Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (AHFS Monograph)
Related treatment guides
- Bowel Preparation
- Diarrhea
- Hepatic Coma
- Hepatic Encephalopathy
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) interactions
Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney).
Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)'s nephrotoxicity and/or ototoxicity and potentiate Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)'s neuromuscular blocking effects.
Oral Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.
Oral Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) side effects
Applies to Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney): oral solution, oral tablet
In addition to its needed effects, some unwanted effects may be caused by Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) (the active ingredient contained in Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney)). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney):
Rare
- Any loss of hearing
- clumsiness
- diarrhea
- difficulty in breathing
- dizziness
- drowsiness
- greatly decreased frequency of urination or amount of urine
- increased amount of gas
- increased thirst
- light-colored, frothy, fatty-appearing stools
- ringing or buzzing or a feeling of fullness in the ears
- skin rash
- unsteadiness
- weakness
Minor Side Effects
Some of the side effects that can occur with Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Irritation or soreness of the mouth or rectal area
- nausea or vomiting
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) contraindications
You should not take this medicine if you are allergic to Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) or similar antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), paromomycin (Humatin, Paromycin), streptomycin, or tobramycin (Nebcin, Tobi).
You should not take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) if you have ulcerative colitis, Crohn's disease, a blockage in your intestines, or other inflammatory bowel disease.
Do not use Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) if you are pregnant. It could harm the unborn baby.
Before you take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), tell your doctor if you have kidney disease, myasthenia gravis, or Parkinson's disease.
Never take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) in larger amounts than recommended, or for longer than 2 weeks. High doses or long-term use of Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) can cause serious kidney problems, or hearing loss that may not be reversible. The longer you take Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), the more likely you are to develop these serious side effects.
To be sure this medication is not causing harmful effects, your kidney function, and your nerve and muscle function will need to be tested often. You may also need hearing tests. Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) can have long lasting effects on your body. Do not miss any follow up visits to your doctor for blood or urine tests.
Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Neomycin (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney), tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.
If you are being treated for hepatic coma, avoid eating foods that are high in protein. Follow your doctor's instructions about any other restrictions on food, beverages, or activity.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) indications
Oral
Cutaneous larva migrans
Adult: 25 mg/kg bid for 2 days repeated after 2 days if required. Max: 3 g/day. Alternatively, 10-15% oral suspension may be used topically.
Max
Dosage: 3 g daily.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Strongyloidiasis
Adult: 25 mg/kg bid for 2-3 days or 50 mg/kg as single dose, when infection is disseminated treament for at least 5 days may be necessary. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Dracunculiasis
Adult: 25-50 mg/kg bid for one day; in massive infection, a further dose of 50 mg/kg may be given after 5-8 days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Trichinosis
Adult: 25 mg/kg bid for 2-4 successive days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Toxocariasis
Adult: 25 mg/kg bid for 5-7 days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Trichostrongyliasis; Trichuriasis; Ascariasis
Adult: 25 mg/kg bid for 2 consecutive days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) description
2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) dosage
Oral
Cutaneous larva migrans
Adult: 25 mg/kg bid for 2 days repeated after 2 days if required. Max: 3 g/day. Alternatively, 10-15% oral suspension may be used topically.
Max
Dosage: 3 g daily.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Strongyloidiasis
Adult: 25 mg/kg bid for 2-3 days or 50 mg/kg as single dose, when infection is disseminated treament for at least 5 days may be necessary. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Dracunculiasis
Adult: 25-50 mg/kg bid for one day; in massive infection, a further dose of 50 mg/kg may be given after 5-8 days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Trichinosis
Adult: 25 mg/kg bid for 2-4 successive days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Toxocariasis
Adult: 25 mg/kg bid for 5-7 days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Oral
Trichostrongyliasis; Trichuriasis; Ascariasis
Adult: 25 mg/kg bid for 2 consecutive days. Max: 3 g/day.
Renal impairment: Use with caution.
Hepatic impairment: Use with caution.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) interactions
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) may compete with other drugs, such as theophylline, for sites of metabolism in the liver, thus elevating the serum levels of such compounds to potentially toxic levels. Therefore, when concomitant use of thiabendazole and xanthine derivatives is anticipated, it may be necessary to monitor blood levels and/or reduce the dosage of such compounds. Such concomitant use should be administered under careful medical supervision.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) side effects
Dizziness; GI disturbances; pruritus, skin rashes; drowsiness, headache, fatigue, drying of mucous membrane; hyperglycaemia, visual disturbances; leucopaenia; tinnitus; hepatic effects; enuresis; crystalluria; bradycardia; hypotension. Transient increase in liver test.
Potentially Fatal: Fatal Stevens-Johnson syndrome, erythema multiforme. Toxic epidermal necrolysis, liver damage.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) contraindications
Hypersensitivity to this product.
Tiabendazole (Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney) is contraindicated as prophylactic treatment for pinworm infestation.
Active ingredient matches for Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney:
Dexamethasone/Neomycin/Tiabendazole in United States.
List of Thiabendazole, Dexamethasone, Neomycin Sulfate Solution Putney substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Dexamethasone/Neomycin/Tiabendazole (United States) | |
| Thiabendazole, Dexamethasone, Neomycin Sulfate (United States) | |
References
- DailyMed. "DEXAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "neomycin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
