Consists of Clavulanate, Ticarcillin
Clavulanate (Ticarcillin/Clavulanate) indications
For use with Amoxicillin, clavulanic acid is suitable for the treatment of infections with Staph. aureus and Bacteroides fragilis, or with beta-lactamase producing H. influenzae and E. coli. (Bacterial infection;)
Clavulanate (Ticarcillin/Clavulanate) description
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase. [PubChem]
What is Ticarcillin (Ticarcillin/Clavulanate)?
Ticarcillin (Ticarcillin/Clavulanate) is an antibiotic in a group of drugs called penicillins. Ticarcillin (Ticarcillin/Clavulanate) fights bacteria in the body.
The combination of Ticarcillin (Ticarcillin/Clavulanate) is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, and skin infections.
Ticarcillin (Ticarcillin/Clavulanate) may also be used for purposes other than those listed in this medication guide.
Ticarcillin (Ticarcillin/Clavulanate) indications
Intravenous
Severe Gram-negative infections; Skin infections; Septicaemia; Peritonitis; Bone and joint infections
Adult: 200-300 mg/kg daily by infusion in divided doses every 4 or 6 hr.
Child: 200-300 mg/kg by infusion in divided doses every 4 or 6 hr.
Renal impairment: Peritoneal dialysis patients: 3 g every 12 hr; haemodialysis patients: 2 g every 12 hr plus an additional dose of 3 g after each dialysis session.
| CrCl (ml/min) | Dosage Recommendation |
| 30-60 | Initial IV loading dose of 3 g, followed by 2 g every 4 hr. |
| 10-30 | Initial IV loading dose of 3 g, followed by 2 g every 8 hr. |
| <10 | Initial IV loading dose of 3 g, followed by 2 g every 12 hr (or 1 g IM every 6 hr). |
| <10> with hepatic impairment | Initial IV loading dose of 3 g, followed by 2 g IV every 24 hr or 1 g IM every 12 hr. |
Incompatibility: Incompatible with aminoglycosides.
Parenteral
Uncomplicated urinary tract infections
Adult: 1 g IM/slow IV Inj every 6 hr.
Child: 50-100 mg/kg in divided doses every 6-8 hr. Do not inject >2 g into each IM site.
Incompatibility: Incompatible with aminoglycosides.
Parenteral
Complicated urinary tract infections
Adult: 150-200 mg/kg daily by IV infusion in divided doses every 4 or 6 hr.
Child: 150-200 mg/kg daily by IV infusion in divided doses every 4 or 6 hr.
Renal impairment: Peritoneal dialysis patients: 3 g every 12 hr; haemodialysis patients: 2 g every 12 hr plus an additional dose of 3 g after each dialysis session.
| CrCl (ml/min) | Dosage Recommendation |
| 30-60 | Initial IV loading dose of 3 g, followed by 2 g every 4 hr. |
| 10-30 | Initial IV loading dose of 3 g, followed by 2 g every 8 hr. |
| <10 | Initial IV loading dose of 3 g, followed by 2 g every 12 hr (or 1 g IM every 6 hr). |
| <10 with hepatic impairment | Initial IV loading dose of 3 g, followed by 2 g IV every 24 hr or 1 g IM every 12 hr. |
Incompatibility: Incompatible with aminoglycosides.
How should I use Ticarcillin (Ticarcillin/Clavulanate)?
Use Ticarcillin (Ticarcillin/Clavulanate) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Ticarcillin (Ticarcillin/Clavulanate) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Ticarcillin (Ticarcillin/Clavulanate) at home, a health care provider will teach you how to use it. Be sure you understand how to use Ticarcillin (Ticarcillin/Clavulanate). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Ticarcillin (Ticarcillin/Clavulanate) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- To clear up your infection completely, use Ticarcillin (Ticarcillin/Clavulanate) for the full course of treatment. Keep using it even if you feel better in a few days.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Ticarcillin (Ticarcillin/Clavulanate), use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Ticarcillin (Ticarcillin/Clavulanate).
Uses of Ticarcillin (Ticarcillin/Clavulanate) in details
Ticarcillin (Ticarcillin/Clavulanate) is used (in combination with clavulanic acid) in the treatment of various bacterial infections involving bones, joints, skin and soft tissue, respiratory tract, ear, nose and throat, kidney and other parts of the body.
Ticarcillin (Ticarcillin/Clavulanate) description
An antibiotic derived from penicillin similar to carbenicillin in action.
Ticarcillin (Ticarcillin/Clavulanate) dosage
Ticarcillin (Ticarcillin/Clavulanate) Dosage
Applies to the following strengths: 1 g; 3 g; 20 g; 30 g
Usual Adult Dose for:
- Febrile Neutropenia
- Intraabdominal Infection
- Joint Infection
- Osteomyelitis
- Pelvic Inflammatory Disease
- Peritonitis
- Pneumonia
- Pyelonephritis
- Septicemia
- Skin or Soft Tissue Infection
- Urinary Tract Infection
Usual Pediatric Dose for:
- Intraabdominal Infection
- Pneumonia
- Skin or Soft Tissue Infection
- Septicemia
- Urinary Tract Infection
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Dose Adjustments
- Dialysis
Usual Adult Dose for Febrile Neutropenia
3 g IV every 4 hours. Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.
Ticarcillin (Ticarcillin/Clavulanate) should be used in combination with another anti-infective agent, usually an aminoglycoside, for the empiric treatment of febrile patients.
Usual Adult Dose for Intraabdominal Infection
3 g IV every 4 hours, for 7 to 14 days depending on the nature and severity of the infection.
Usual Adult Dose for Joint Infection
3 g IV every 4 hours for up to 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.
Usual Adult Dose for Osteomyelitis
3 g IV every 4 hours. Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.
Usual Adult Dose for Pelvic Inflammatory Disease
3 g IV every 4 to 6 hours.
Parenteral therapy should continue for 48 hours after clinical improvement is observed, at which time oral therapy may be initiated and continued for a total of 14 days of treatment.
If the patient is not pregnant, appropriate treatment for possible chlamydia infection should be initiated and any sexual partner(s) should be evaluated.
The Centers for Disease Control and Prevention currently recommend cefotetan or cefoxitin plus doxycycline, or clindamycin plus gentamicin for the treatment of pelvic inflammatory disease.
Usual Adult Dose for Peritonitis
3 g IV every 4 hours. Ticarcillin (Ticarcillin/Clavulanate) is generally used as part of combination therapy when treating peritonitis. Therapy should be continued for approximately 10 to 14 days.
Intraperitoneal cefazolin plus ceftazidime are recommended for treatment of peritoneal dialysis-associated peritonitis.
Usual Adult Dose for Pneumonia
3 g IV every 4 hours for 21 to 28 days, depending on the nature and severity of the infection.
Usual Adult Dose for Pyelonephritis
3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.
Usual Adult Dose for Septicemia
3 g IV every 4 hours for 14 days, depending on the nature and severity of the infection.
Usual Adult Dose for Skin or Soft Tissue Infection
3 g IV every 4 hours for 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.
Usual Adult Dose for Urinary Tract Infection
Complicated: 3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.
Uncomplicated: 1 g IM or IV every 6 hours
Usual Pediatric Dose for Intraabdominal Infection
Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours
1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose
Usual Pediatric Dose for Pneumonia
Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours
1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose
Usual Pediatric Dose for Skin or Soft Tissue Infection
Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours
1 month to 12 years:
< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose
Usual Pediatric Dose for Septicemia
Neonates:
< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours
< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours
> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours
> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours
1 month to 12 years:
< 40 kg: 200 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours
> 40 kg: Adult dose
Usual Pediatric Dose for Urinary Tract Infection
Uncomplicated infections:
1 month to 12 years:
< 40 kg: 50 to 100 mg/kg/day IV or IM in equally divided doses every 6 to 8 hours.
> 40 kg: Adult dose.
Complicated infections:
1 month to 12 years:
< 40 kg: 150 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours.
> 40 kg: Adult dose.
Renal Dose Adjustments
Adults:
CrCl < 10 mL/min: Initial loading dose of 3 g followed by 2 g IV every 12 hours or 1 g IM every 6 hours.
CrCl 10 to 30 mL/min: Initial loading dose of 3 g followed by 2 g IV every 8 hours.
CrCl 30 to 60 mL/min: Initial loading dose of 3 g followed by 2 g IV every 4 hours.
Liver Dose Adjustments
Adults:
Hepatic dysfunction and CrCl < 10 mL/min: 3 g IV once as a loading dose, followed by 2 g IV every 24 hours.
Dose Adjustments
Doses as high as 400 mg/kg/day IV equally divided every 4 to 6 hours have been used to treat acute pulmonary exacerbations of cystic fibrosis.
Dialysis
Adults:
Hemodialysis: 3 g IV once as a loading dose, followed by 2 g IV every 12 hours supplemented with 3 g after each dialysis.
Peritoneal dialysis: 3 g IV every 12 hours
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
More about Ticarcillin (Ticarcillin/Clavulanate)
- Ticarcillin (Ticarcillin/Clavulanate) Side Effects
- During Pregnancy or Breastfeeding
- Drug Interactions
- Drug class: antipseudomonal penicillins
Professional resources
Related treatment guides
- Bone infection
- Febrile Neutropenia
- Intraabdominal Infection
- Joint Infection
- ... +7 more
Ticarcillin (Ticarcillin/Clavulanate) interactions
See also:
What other drugs will affect Ticarcillin (Ticarcillin/Clavulanate)?
Probenecid decreases clearance of Ticarcillin (Ticarcillin/Clavulanate). Increased bleeding risk with warfarin, acenocoumarol. Possible increase in ciclosporin, methotrexate levels with concurrent use. Possible contraceptive failure with combined oral contraceptives.
Ticarcillin (Ticarcillin/Clavulanate) side effects
See also:
What are the possible side effects of Ticarcillin (Ticarcillin/Clavulanate)?
Pain at the inj site and phlebitis; electrolyte disturbances (hypokalaemia or hypernatraemia); dose-dependent coagulation defect; purpura and haemorrhage; hypersensitivity reactions; haemolytic anaemia; interstitial nephritis; neutropenia; CNS toxicity including convulsions; diarrhoea; pseudomembranous colitis. Haemorrhagic cystitis especially in cystic fibrosis patients.
Potentially Fatal: Anaphylaxis.
Ticarcillin (Ticarcillin/Clavulanate) contraindications
See also:
What is the most important information I should know about Ticarcillin (Ticarcillin/Clavulanate)?
Hypersensitivity to penicillins.
Active ingredient matches for Ticarcillin/Clavulanate:
List of Ticarcillin/Clavulanate substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Clavulanate/Ticarcillin | |
| Ticarcillin/ clavulanate | |
References
- PubChem. "TICARCILLIN". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "TICARCILLIN". http://www.drugbank.ca/drugs/DB01607 (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
