• Dosage of Ticarcillin in details
• Ticarcillin interactions
• Ticarcillin reviews

Dosage of Ticarcillin in details

Ticarcillin Dosage

Applies to the following strengths: 1 g; 3 g; 20 g; 30 g

Usual Adult Dose for:

• Febrile Neutropenia
• Intraabdominal Infection
• Joint Infection
• Osteomyelitis
• Pelvic Inflammatory Disease
• Peritonitis
• Pneumonia
• Pyelonephritis
• Septicemia
• Skin or Soft Tissue Infection
• Urinary Tract Infection

Usual Pediatric Dose for:

• Intraabdominal Infection
• Pneumonia
• Skin or Soft Tissue Infection
• Septicemia
• Urinary Tract Infection

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Dialysis

Usual Adult Dose for Febrile Neutropenia

3 g IV every 4 hours. Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient has been afebrile for 24 hours after the absolute neutrophil count has been greater than 500 cells/mm3.

Ticarcillin should be used in combination with another anti-infective agent, usually an aminoglycoside, for the empiric treatment of febrile patients.

Usual Adult Dose for Intraabdominal Infection

3 g IV every 4 hours, for 7 to 14 days depending on the nature and severity of the infection.

Usual Adult Dose for Joint Infection

3 g IV every 4 hours for up to 3 or 4 weeks, depending on the nature and severity of the infection. Longer therapy, sometimes up to 6 weeks, may be necessary for prosthetic joint infections.

Usual Adult Dose for Osteomyelitis

3 g IV every 4 hours. Therapy should be continued for 4 to 6 weeks. Chronic osteomyelitis may require additional oral antimicrobial therapy, possibly up to 6 months.

Usual Adult Dose for Pelvic Inflammatory Disease

3 g IV every 4 to 6 hours.

Parenteral therapy should continue for 48 hours after clinical improvement is observed, at which time oral therapy may be initiated and continued for a total of 14 days of treatment.

If the patient is not pregnant, appropriate treatment for possible chlamydia infection should be initiated and any sexual partner(s) should be evaluated.

The Centers for Disease Control and Prevention currently recommend cefotetan or cefoxitin plus doxycycline, or clindamycin plus gentamicin for the treatment of pelvic inflammatory disease.

Usual Adult Dose for Peritonitis

3 g IV every 4 hours. Ticarcillin is generally used as part of combination therapy when treating peritonitis. Therapy should be continued for approximately 10 to 14 days.

Intraperitoneal cefazolin plus ceftazidime are recommended for treatment of peritoneal dialysis-associated peritonitis.

Usual Adult Dose for Pneumonia

3 g IV every 4 hours for 21 to 28 days, depending on the nature and severity of the infection.

Usual Adult Dose for Pyelonephritis

3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Septicemia

3 g IV every 4 hours for 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Skin or Soft Tissue Infection

3 g IV every 4 hours for 7 to 10 days, or for 3 days after acute inflammation resolves, depending on the nature and severity of the infection.

Usual Adult Dose for Urinary Tract Infection

Complicated: 3 g IV every 4 to 6 hours for 14 days, depending on the nature and severity of the infection.

Uncomplicated: 1 g IM or IV every 6 hours

Usual Pediatric Dose for Intraabdominal Infection

Neonates:

< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours

< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours

> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:

< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours

> 40 kg: Adult dose

Usual Pediatric Dose for Pneumonia

Neonates:

< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours

< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours

> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:

< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours

> 40 kg: Adult dose

Usual Pediatric Dose for Skin or Soft Tissue Infection

Neonates:

< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours

< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours

> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:

< 40 kg: 100 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours

> 40 kg: Adult dose

Usual Pediatric Dose for Septicemia

Neonates:

< 7 days, birthweight < 2000 g: 75 mg/kg IV every 12 hours

< 7 days, birthweight > 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight < 1200 g: 75 mg/kg every 12 hours

> 7 days, birthweight < 2000 g: 75 mg/kg IV every 8 hours

> 7 days, birthweight > 2000 g: 75 mg/kg every 6 hours or 100 mg/kg IV every 8 hours

1 month to 12 years:

< 40 kg: 200 to 300 mg/kg/day IV in equally divided doses every 4 to 6 hours

> 40 kg: Adult dose

Usual Pediatric Dose for Urinary Tract Infection

Uncomplicated infections:

1 month to 12 years:

< 40 kg: 50 to 100 mg/kg/day IV or IM in equally divided doses every 6 to 8 hours.

> 40 kg: Adult dose.

Complicated infections:

1 month to 12 years:

< 40 kg: 150 to 200 mg/kg/day IV in equally divided doses every 4 to 6 hours.

> 40 kg: Adult dose.

Renal Dose Adjustments

Adults:

CrCl < 10 mL/min: Initial loading dose of 3 g followed by 2 g IV every 12 hours or 1 g IM every 6 hours.

CrCl 10 to 30 mL/min: Initial loading dose of 3 g followed by 2 g IV every 8 hours.

CrCl 30 to 60 mL/min: Initial loading dose of 3 g followed by 2 g IV every 4 hours.

Liver Dose Adjustments

Adults:

Hepatic dysfunction and CrCl < 10 mL/min: 3 g IV once as a loading dose, followed by 2 g IV every 24 hours.

Dose Adjustments

Doses as high as 400 mg/kg/day IV equally divided every 4 to 6 hours have been used to treat acute pulmonary exacerbations of cystic fibrosis.

Dialysis

Adults:

Hemodialysis: 3 g IV once as a loading dose, followed by 2 g IV every 12 hours supplemented with 3 g after each dialysis.

Peritoneal dialysis: 3 g IV every 12 hours

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

More about Ticarcillin

• Ticarcillin Side Effects
• During Pregnancy or Breastfeeding
• Drug Interactions
• Drug class: antipseudomonal penicillins

Professional resources

Related treatment guides

• Bone infection
• Febrile Neutropenia
• Intraabdominal Infection
• Joint Infection
• ... +7 more

What other drugs will affect Ticarcillin?

There may be other drugs that can affect Ticarcillin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Ticarcillin interactions

Probenecid decreases clearance of Ticarcillin. Increased bleeding risk with warfarin, acenocoumarol. Possible increase in ciclosporin, methotrexate levels with concurrent use. Possible contraceptive failure with combined oral contraceptives.

References

1. FDA/SPL Indexing Data. "F93UJX4SWT: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
2. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
3. European Chemicals Agency - ECHA. "Ticarcillin: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Ticarcillin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Ticarcillin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reviews

There are no reviews yet. Be the first to write one!

Your name:  Email:  Spam protection:  < Type 19 here

Information checked by Dr. Sachin Kumar, MD Pharmacology