Timolet GFS Uses

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What is Timolet GFS?

Timolet GFS is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Timolet GFS is also used after an acute heart attack to decrease its severity and prevent another heart attack. It may also be used to help prevent migraine headaches.

Timolet GFS is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

Timolet GFS is available only with your doctor's prescription.

Timolet GFS indications

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Hypertension

Timolet GFS tablets are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.

Myocardial Infarction

Timolet GFS is indicated in patients who have survived the acute phase of myocardial infarction, and are clinically stable, to reduce cardiovascular mortality and the risk of reinfarction.

Migraine

Timolet GFS is indicated for the prophylaxis of migraine headache.

How should I use Timolet GFS?

Use Timolet GFS as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Timolet GFS.

Uses of Timolet GFS in details

Use: Labeled Indications

Hypertension: Management of hypertension. Note: Beta-blockers are not recommended as first-line therapy (ACC/AHA [Whelton 2017]).

Migraine prophylaxis: Prophylaxis of migraine

Myocardial infarction (secondary prevention): To reduce mortality following MI

Off Label Uses

Atrial fibrillation (rate-control)

Data from a randomized, placebo-controlled trial in patients with atrial fibrillation (AF) associated with a rapid ventricular response while receiving digoxin supports the use of oral Timolet GFS in patients with chronic AF.

Based on the 2014 AHA/ACC/HRS guideline for the management of patients with AF, the use of beta-blockers for ventricular rate control in patients with paroxysmal, persistent, or permanent AF is effective and recommended for this condition.

Timolet GFS description

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A beta-adrenergic antagonist similar in action to propranolol. The levo-isomer is the more active. Timolet GFS has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of migraine disorders and tremor.

Timolet GFS dosage

Patients should be instructed to invert the closed container and shake once before each use. It is not necessary to shake the container more than once. Other topically applied ophthalmic medications should be administered at least 10 minutes before Timolet GFS Ophthalmic Gel Forming Solution.

Timolet GFS Ophthalmic Gel Forming Solution is available in concentrations of 0.25% and 0.5%. The dose is one drop of Timolet GFS Ophthalmic Gel Forming Solution (either 0.25% or 0.5%) in the affected eye(s) once a day.

Because in some patients the pressure-lowering response to Timolet GFS Ophthalmic Gel Forming Solution may require a few weeks to stabilize, evaluation should include a determination of intraocular pressure after approximately 4 weeks of treatment with Timolet GFS Ophthalmic Gel Forming Solution.

Dosages higher than one drop of 0.5% Timolet GFS Ophthalmic Gel Forming Solution once a day have not been studied. If the patient's intraocular pressure is still not at a satisfactory level on this regimen, concomitant therapy can be considered. The concomitant use of two topical beta-adrenergic blocking agents is not recommended.

When patients have been switched from therapy with Timolet GFS ophthalmic solution administered twice daily to Timolet GFS Ophthalmic Gel Forming Solution administered once daily, the ocular hypotensive effect has remained consistent.

Timolet GFS interactions

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What other drugs will affect Timolet GFS?

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Although TIMOPTIC (Timolet GFS ophthalmic solution) used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with TIMOPTIC (Timolet GFS ophthalmic solution) and epinephrine has been reported occasionally.

Beta-adrenergic blocking agents: Patients who are receiving a beta-adrenergic blocking agent orally and Preservative-free Timolet GFS should be observed for potential additive effects of beta-blockade, both systemic and on intraocular pressure. The concomitant use of two topical beta-adrenergic blocking agents is not recommended.

Calcium antagonists: Caution should be used in the coadministration of beta-adrenergic blocking agents, such as Preservative-free Timolet GFS, and oral or intravenous calcium antagonists, because of possible atrioventricular conduction disturbances, left ventricular failure, and hypotension. In patients with impaired cardiac function, coadministration should be avoided.

Catecholamine-depleting drugs: Close observation of the patient is recommended when a beta blocker is administered to patients receiving catecholamine-depleting drugs such as reserpine, because of possible additive effects and the production of hypotension and/or marked bradycardia, which may result in vertigo, syncope, or postural hypotension.

Digitalis and calcium antagonists: The concomitant use of beta-adrenergic blocking agents with digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time.

CYP2D6 inhibitors: Potentiated systemic beta-blockade (e.g., decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (e.g., quinidine, SSRIs) and Timolet GFS.

Clonidine:

Oral beta-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. There have been no reports of exacerbation of rebound hypertension with ophthalmic Timolet GFS. Injectable epinephrine:

Timolet GFS side effects

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What are the possible side effects of Timolet GFS?

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Timolet GFS tablets are usually well tolerated in properly selected patients. Most adverse effects have been mild and transient.

In a multi-center (12 week) clinical trial comparing Timolet GFS and placebo in hypertensive patients, the following adverse reactions were reported spontaneously and considered to be causally related to Timolet GFS:

Timolet GFS

(n=176)

%

Placebo

(n=168)

%

BODY AS A WHOLE

fatigue/tiredness

3.4

0.6

headache

1.7

1.8

chest pain

0.6

0

asthenia

0.6

0

CARDIOVASCULAR

bradycardia

9.1

0

arrhythmia

1.1

0.6

syncope

0.6

0

edema

0.6

1.2

DIGESTIVE

dyspepsia

0.6

0.6

nausea

0.6

0

SKIN

pruritus

1.1

0

NERVOUS SYSTEM

dizziness

2.3

1.2

vertigo

0.6

0

paresthesia

0.6

0

PSYCHIATRIC

decreased libido

0.6

0

RESPIRATORY

dyspnea

1.7

0.6

bronchial spasm

0.6

0

rales

0.6

0

SPECIAL SENSES

eye irritation

1.1

0.6

tinnitus

0.6

0

These data are representative of the incidence of adverse effects that may be observed in properly selected patients treated with Timolet GFS, i.e., excluding patients with bronchospastic disease, congestive heart failure or other contraindications to beta-blocker therapy.

In patients with migraine the incidence of bradycardia was 5 percent.

In a coronary artery disease population studied in the Norwegian multi-center trial, the frequency of the principal adverse reactions and the frequency with which these resulted in discontinuation of therapy in the Timolet GFS and placebo groups were:

Adverse Reaction* Withdrawal†
Timolet GFS

(n=945)

%

Placebo

(n=939)

%

Timolet GFS

(n=945)

%

Placebo

(n=939)

%

*
When an adverse reaction recurred in a patient, it is listed only once.
Only principal reason for withdrawal in each patient is listed. These adverse reactions can also occur in patients treated for hypertension.

Asthenia or Fatigue

5

1

<1

<1

Heart Rate < 40 beats/minute

5

<1

4

<1

Cardiac Failure-Nonfatal

8

7

3

2

Hypotension

3

2

3

1

Pulmonary Edema-Nonfatal

2

<1

<1

<1

Claudication

3

3

1

<1

AV Block 2nd or 3rd Degree

<1

<1

<1

<1

Sinoatrial Block

<1

<1

<1

<1

Cold Hands and Feet

8

<1

<1

0

Nausea or Digestive Disorders

8

6

1

<1

Dizziness

6

4

1

0

Bronchial Obstruction

2

<1

1

<1

The following additional adverse effects have been reported in clinical experience with the drug: Body as a Whole: anaphylaxis, extremity pain, decreased exercise tolerance, weight loss, fever; Cardiovascular: cardiac arrest, cardiac failure, cerebral vascular accident, worsening of angina pectoris, worsening of arterial insufficiency, Raynaud's phenomenon, palpitations, vasodilatation; Digestive: gastrointestinal pain, hepatomegaly, vomiting, diarrhea, dyspepsia; Hematologic: nonthrombocytopenic purpura; Endocrine: hyperglycemia, hypoglycemia; Skin: rash, skin irritation, increased pigmentation, sweating, alopecia; Musculoskeletal: arthralgia; Nervous System: local weakness, increase in signs and symptoms of myasthenia gravis; Psychiatric: depression, nightmares, somnolence, insomnia, nervousness, diminished concentration, hallucinations; Respiratory: cough; Special Senses: visual disturbances, diplopia, ptosis, dry eyes; Urogenital: impotence, urination difficulties.

There have been reports of retroperitoneal fibrosis in patients receiving Timolet GFS and in patients receiving other beta-adrenergic blocking agents. A causal relationship between this condition and therapy with beta-adrenergic blocking agents has not been established.

Potential Adverse Effects

In addition, a variety of adverse effects not observed in clinical trials with Timolet GFS, but reported with other beta-adrenergic blocking agents, should be considered potential adverse effects of Timolet GFS. Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics; Cardiovascular: Intensification of AV block; Digestive: Mesenteric arterial thrombosis, ischemic colitis; Hematologic: Agranulocytosis, thrombocytopenic purpura; Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm with respiratory distress; Miscellaneous: Peyronie's disease.

There have been reports of a syndrome comprising psoriasiform skin rash, conjunctivitis sicca, otitis, and sclerosing serositis attributed to the beta-adrenergic receptor blocking agent, practolol. This syndrome has not been reported with Timolet GFS.

Clinical Laboratory Test Findings

Clinically important changes in standard laboratory parameters were rarely associated with the administration of Timolet GFS. Slight increases in blood urea nitrogen, serum potassium, uric acid, and triglycerides, and slight decreases in hemoglobin, hematocrit and HDL cholesterol occurred, but were not progressive or associated with clinical manifestations. Increases in liver function tests have been reported.

Timolet GFS contraindications

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What is the most important information I should know about Timolet GFS?

Hypersensitivity to Timolet GFS or any component of the formulation; sinus bradycardia; heart block greater than first degree (except in patients with a functioning artificial pacemaker); cardiogenic shock; uncompensated cardiac failure; bronchospastic disease

Documentation of allergenic cross-reactivity for beta-blockers is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

Canadian labeling: Additional contraindications (not in US labeling): Right ventricular failure secondary to pulmonary hypertension; significant cardiomegaly; allergic rhinitis; severe chronic obstructive pulmonary disease; anesthesia with agents that produce myocardial depression (eg, ether hypersensitivity to Timolet GFS)

Active ingredient matches for Timolet GFS:

Timolol Maleate

Timolol


Unit description / dosage (Manufacturer)Price, USD
TIMOLET GFS Eye Gel/ Ointment / 0.005 / 3ml units (Sun Pharmaceuticals (Avesta Divison))$ 0.93
Timolet GFS 0.5% GEL / 3ml$ 0.83
Timolet GFS Eye 3 ml Drop$ 1.07
Timolet GFS 0.5% GEL / 3ml$ 0.83

List of Timolet GFS substitutes (brand and generic names):

TIMOLET-GFS eye gel 0.5 % x 3ml (Sun (Milmet))$ 0.83
TIMOLINA EYE DROP 1 packet / 5 ML eye drop each (Chethana Pharmaceuticals)$ 0.60
Timolo Eye 5 ml Drop (Bell Pharma Pvt. Ltd.)$ 0.24
TIMOLO 0.5% EYE DROPS 1 packet / 5 ML eye drop each (Bell Pharma Pvt. Ltd.)$ 0.58
Timolo 0.5% Eye Drop (Bell Pharma Pvt. Ltd.)$ 0.58
Solution; Ophthalmic; Timolol Maleate 0.25% (Calibre Pharmaceutical Pvt. Ltd.)
Solution; Ophthalmic; Timolol Maleate 0.5% (Calibre Pharmaceutical Pvt. Ltd.)
Solution; Ophthalmic; Timolol 0.5% (Calibre Pharmaceutical Pvt. Ltd.)
Solution; Ophthalmic; Timolol 0.25% (Calibre Pharmaceutical Pvt. Ltd.)
Solution; Ophthalmic; Timolol Maleate 0.1% (Calibre Pharmaceutical Pvt. Ltd.)
Tablet; Oral; Timolol Maleate 10 mg (Calibre Pharmaceutical Pvt. Ltd.)
Tablet; Oral; Timolol Maleate 20 mg (Calibre Pharmaceutical Pvt. Ltd.)
Tablet; Oral; Timolol Maleate 5 mg (Calibre Pharmaceutical Pvt. Ltd.)
Drops; Ophthalmic; Timolol 0.25% (Calibre Pharmaceutical Pvt. Ltd.)
Drops; Ophthalmic; Timolol 0.5% (Calibre Pharmaceutical Pvt. Ltd.)
Betimol 0.5% Solution 15ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 152.24
Timolol maleate powder (Calibre Pharmaceutical Pvt. Ltd.)$ 107.10
Betimol 0.5% Solution 10ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 106.88
Betimol 0.25% Solution 15ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 93.56
Timoptic-XE 0.5% Gel Forming Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 85.09
Timoptic 0.5% Solution 10ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 83.20
Timoptic-XE 0.25% Gel Forming Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 65.37
Betimol 0.5% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 63.43
Timolol Maleate 0.5% Gel Forming Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 60.84
Timoptic 0.5% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 59.80
Timolol Maleate 0.25% Gel Forming Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 59.71
Betimol 0.25% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 55.56
Timolol Maleate 0.5% Solution 15ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 50.70
Betimol 0.25% Solution 10ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 49.99
Timolol Maleate 0.5% Gel Forming Solution 2.5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 46.74
Timolol Maleate 0.25% Solution 15ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 43.68
Timoptic 0.25% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 43.06
Istalol 0.5% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 36.43
Timolol Maleate 0.5% Solution 10ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 33.58
Timolol Maleate 0.25% Solution 10ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 28.87
Timoptic-XE 0.25% Gel Forming Solution 2.5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 23.99
Timolol Maleate 0.5% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 17.68
Timolol Maleate 0.25% Solution 5ml Bottle (Calibre Pharmaceutical Pvt. Ltd.)$ 15.60
Timoptic-xe 0.5% eye solution (Calibre Pharmaceutical Pvt. Ltd.)$ 13.60
Timoptic-xe 0.25% eye solution (Calibre Pharmaceutical Pvt. Ltd.)$ 11.51
Betimol 0.5% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 10.15
Betimol 0.25% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 9.19
Timoptic 0.5% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 8.63
Timoptic 0.25% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 7.32
Timoptic-Xe 0.5 % Long Acting Gellan Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 4.64
Timoptic 0.5% ocudose drops (Calibre Pharmaceutical Pvt. Ltd.)$ 4.57
Timoptic-Xe 0.25 % Long Acting Gellan Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 3.88
Timoptic 0.25% ocudose drops (Calibre Pharmaceutical Pvt. Ltd.)$ 3.80
Timoptic 0.5 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 3.63
Timolol 0.5% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 3.24
Timolol 0.25% eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 2.78
Apo-Timop 0.5 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.95
Mylan-Timolol 0.5 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.95
Pms-Timolol 0.5 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.95
Sandoz Timolol Maleate 0.5 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.95
Apo-Timop 0.25 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.62
Mylan-Timolol 0.25 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.62
Pms-Timolol 0.25 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.62
Sandoz Timolol Maleate 0.25 % Solution (Calibre Pharmaceutical Pvt. Ltd.)$ 1.62
Timolol maleate 20 mg tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.94
Hydrocortisone 2.5% lotion (Calibre Pharmaceutical Pvt. Ltd.)$ 0.60
Apo-Timol 20 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.59
Novo-Timol 20 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.59
Timolol maleate 10 mg tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.51
Timolol maleate 5 mg tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.41
Apo-Timol 10 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.30
Novo-Timol 10 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.30
Nu-Timolol 10 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.30
Apo-Timol 5 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.19
Novo-Timol 5 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.19
Nu-Timolol 5 mg Tablet (Calibre Pharmaceutical Pvt. Ltd.)$ 0.19
Aquanil hc 1% lotion (Calibre Pharmaceutical Pvt. Ltd.)$ 0.12
Aquanil cleanser (Calibre Pharmaceutical Pvt. Ltd.)$ 0.03
Timolol 2.5mg/ 10ml - 1 Eye drops (Calibre Pharmaceutical Pvt. Ltd.)$ 12.00
Timolol / Medicine 0.25 % x 5 mL (Calibre Pharmaceutical Pvt. Ltd.)
Timolol / Medicine 0.5 % x 5 mL (Calibre Pharmaceutical Pvt. Ltd.)
Timolol / Wu Fu 0.25 % x 5 mL (Calibre Pharmaceutical Pvt. Ltd.)
Timolol / Wu Fu 0.5 % x 5 mL (Calibre Pharmaceutical Pvt. Ltd.)
Timolol Eye 5 ml Drop (Calibre Pharmaceutical Pvt. Ltd.)$ 0.07
Timolol 0, 5% Alcon 0.5 % x 1 Bottle 5 mL

References

  1. DailyMed. "TIMOLOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "timolol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "timolol". http://www.drugbank.ca/drugs/DB00373 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Timolet GFS are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Timolet GFS. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet


1 consumer reported price estimates

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The below mentioned numbers have been reported by ndrugs.com website users about whether the Timolet GFS drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Not expensive1
100.0%


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No survey data has been collected yet


1 consumer reported age

Users%
1-51
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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