Timolol Alcon 0.50% Uses

• Timolol Alcon 0.50% indications
• Uses of Timolol Alcon 0.50% in details
• Timolol Alcon 0.50% description
• Timolol Alcon 0.50% dosage
• Timolol Alcon 0.50% interactions
• Timolol Alcon 0.50% side effects
• Timolol Alcon 0.50% contraindications

What is Timolol Alcon 0.50%?

Timolol Alcon 0.50% is used alone or together with other medicines (such as hydrochlorothiazide) to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Timolol Alcon 0.50% is also used after an acute heart attack to decrease its severity and prevent another heart attack. It may also be used to help prevent migraine headaches.

Timolol Alcon 0.50% is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

Timolol Alcon 0.50% is available only with your doctor's prescription.

Timolol Alcon 0.50% indications

Hypertension

Timolol Alcon 0.50% (Timolol Alcon 0.50%) is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents, especially thiazide-type diuretics.

Myocardial Infarction

Timolol Alcon 0.50% (Timolol Alcon 0.50%) is indicated in patients who have survived the acute phase of myocardial infarction, and are clinically stable, to reduce cardiovascular mortality and the risk of reinfarction.

Migraine

Timolol Alcon 0.50% (Timolol Alcon 0.50%) is indicated for the prophylaxis of migraine headache.

How should I use Timolol Alcon 0.50%?

Use Timolol Alcon 0.50% drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Timolol Alcon 0.50% drops. Talk to your pharmacist if you have questions about this information.
• Timolol Alcon 0.50% drops is only for the eye. Do not get it in your nose or mouth.
• Soft contact lenses may absorb a chemical contained in some brands of Timolol Alcon 0.50% drops. Remove contact lenses before you use Timolol Alcon 0.50% drops; lenses may be placed back in the eyes 15 minutes after use of Timolol Alcon 0.50% drops.
• To use Timolol Alcon 0.50% drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
• Use Timolol Alcon 0.50% drops at least 10 minutes before or after any other medicine that you put in your eye.
• Using Timolol Alcon 0.50% drops at the same time each day will help you remember to use it.
• Continue to use Timolol Alcon 0.50% drops even if you feel well. Do not miss any doses.
• If you miss a dose of Timolol Alcon 0.50% drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Timolol Alcon 0.50% drops.

Uses of Timolol Alcon 0.50% in details

Use: Labeled Indications

Hypertension: Management of hypertension. Note: Beta-blockers are not recommended as first-line therapy (ACC/AHA [Whelton 2017]).

Migraine prophylaxis: Prophylaxis of migraine

Myocardial infarction (secondary prevention): To reduce mortality following MI

Off Label Uses

Atrial fibrillation (rate-control)

Data from a randomized, placebo-controlled trial in patients with atrial fibrillation (AF) associated with a rapid ventricular response while receiving digoxin supports the use of oral Timolol Alcon 0.50% in patients with chronic AF.

Based on the 2014 AHA/ACC/HRS guideline for the management of patients with AF, the use of beta-blockers for ventricular rate control in patients with paroxysmal, persistent, or permanent AF is effective and recommended for this condition.

Timolol Alcon 0.50% description

Each mL of Timolol Alcon 0.50% 0.5% contains 5 mg of Timolol Alcon 0.50% (6.8 mg of Timolol Alcon 0.50% maleate). It also contains the following inactive ingredients: Gellan gum, tromethamine, mannitol and water for injection. Benzododecinium bromide 0.012% is added as preservative.

Preservative-free Timolol Alcon 0.50% contains the previously mentioned active and inactive ingredients except for the preservative benzododecinium bromide.

Timolol Alcon 0.50% maleate is a β-adrenergic receptor blocking agent. It is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z)-2-butenedioate (1:1) (salt). Timolol Alcon 0.50% maleate possesses an asymmetric carbon atom and is provided as the levo isomer. The empirical formula is C₁₃H₂₄N₄0₃S·C₄H₄0₄.

Timolol Alcon 0.50% maleate has a molecular weight of 432.50. It is a white, odourless, crystalline powder which is soluble in water, methanol and alcohol.

Gellan solution contains a highly purified anionic heteropolysaccharide derived from gellan gum. Aqueous solutions of gellan gum form a clear transparent gel in the presence of cations. The concentration of sodium cations in tears is ideally suited to cause gelation of the material when topically instilled in the conjunctival sac.

Timolol Alcon 0.50% dosage

Hypertension

The usual initial dosage of Timolol Alcon 0.50% (Timolol Alcon 0.50%) is 10 mg twice a day, whether used alone or added to diuretic therapy. Dosage may be increased or decreased depending on heart rate and blood pressure response. The usual total maintenance dosage is 20-40 mg per day. Increases in dosage to a maximum of 60 mg per day divided into two doses may be necessary. There should be an interval of at least seven days between increases in dosages.

Timolol Alcon 0.50% (Timolol Alcon 0.50%) may be used with a thiazide diuretic or with other antihypertensive agents. Patients should be observed carefully during initiation of such concomitant therapy.

Myocardial Infarction

The recommended dosage for long-term prophylactic use in patients who have survived the acute phase of a myocardial infarction is 10 mg given twice daily.

Migraine

The usual initial dosage of Timolol Alcon 0.50% (Timolol Alcon 0.50%) is 10 mg twice a day. During maintenance therapy the 20 mg daily dosage may be administered as a single dose. Total daily dosage may be increased to a maximum of 30 mg, given in divided doses, or decreased to 10 mg once per day, depending on clinical response and tolerability. If a satisfactory response is not obtained after 6-8 weeks use of the maximum daily dosage, therapy with Timolol Alcon 0.50% (Timolol Alcon 0.50%) should be discontinued.

How supplied

No. 3343 — Tablets Timolol Alcon 0.50% (Timolol Alcon 0.50%), 5 mg, are light blue, round, compressed tablets, with code MSD 59 on one side and Timolol Alcon 0.50% (Timolol Alcon 0.50%) on the other. They are supplied as follows:

NDC 0006-0059-68 bottles of 100.

No. 3344 — Tablets Timolol Alcon 0.50% (Timolol Alcon 0.50%), 10 mg, are light blue, round, scored, compressed tablets, with code MSD 136 on one side and Timolol Alcon 0.50% (Timolol Alcon 0.50%) on the other. They are supplied as follows:

NDC 0006-0136-68 bottles of 100

No. 3371 — Tablets Timolol Alcon 0.50% (Timolol Alcon 0.50%), 20 mg, are light blue, capsule shaped, scored, compressed tablets, with code MSD 437 on one side and Timolol Alcon 0.50% (Timolol Alcon 0.50%) on the other. They are supplied as follows:

NDC 0006-0437-68 bottles of 100

Storage

Store at controlled room temperature, 15-30°C (59-86°F). Keep container tightly closed. Protect from light.

MERCK AND CO., INC., Whitehouse Station, NJ 08889, USA. Issued April 2001. FDA Rev date: 2/25/2003

Timolol Alcon 0.50% interactions

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What other drugs will affect Timolol Alcon 0.50%?

Timolol Alcon 0.50% should be used cautiously in patients with hyperthyroidism, hypertension and cardiac arrhythmias. All vasopressors should be used cautiously in patients taking monoamine oxidase (MAO) inhibitors.

Timolol Alcon 0.50% should not be administered concomitantly with other sympathomimetic drugs (such as isoproterenol) because of possible additive effects and increased toxicity.

Combined effects may induce serious cardiac arrhythmias. They may be administered alternately when the preceding effect of other such drug has subsided.

Administration of epinephrine to patients receiving cyclopropane or halogenated hydrocarbon general anesthetics such as halothane which sensitize the myocardium, may induce cardiac arrhythmia.. When encountered, such arrhythmias may respond to administration of a beta-adrenergic blocking drug. Timolol Alcon 0.50% also should be used cautiously with other drugs (e.g., digitalis, glycosides) that sensitize the myocardium to the actions of sympathomimetic drugs.

Diuretic agents may decrease vascular response to pressor drugs such as epinephrine.

Timolol Alcon 0.50% may antagonize the neuron blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.

Timolol Alcon 0.50% side effects

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What are the possible side effects of Timolol Alcon 0.50%?

Timolol Alcon 0.50% (Timolol Alcon 0.50%) is usually well tolerated in properly selected patients. Most adverse effects have been mild and transient.

In a multicenter (12-week) clinical trial comparing Timolol Alcon 0.50% maleate and placebo in hypertensive patients, the following adverse reactions were reported spontaneously and considered to be causally related to Timolol Alcon 0.50% maleate:

	Timolol Alcon 0.50% Maleate (n = 176) %	Placebo (n = 168) %
BODY AS A WHOLE
fatigue/tiredness	3.4	0.6
headache	1.7	1.8
chest pain	0.6	0
asthenia	0.6	0
CARDIOVASCULAR
bradycardia	9.1	0
arrhythmia	1.1	0.6
syncope	0.6	0
edema	0.6	1.2
DIGESTIVE
dyspepsia	0.6	0.6
nausea	0.6	0
SKIN
pruritus	1.1	0
NERVOUS SYSTEM
dizziness	2.3	1.2
vertigo	0.6	0
paresthesia	0.6	0
PSYCHIATRIC
decreased libido	0.6	0
RESPIRATORY
dyspnea	1.7	0.6
bronchial spasm	0.6	0
rales	0.6	0
SPECIAL SENSES
eye irritation	1.1	0.6
tinnitus	0.6	0

These data are representative of the incidence of adverse effects that may be observed in properly selected patients treated with Timolol Alcon 0.50% (Timolol Alcon 0.50%), i.e., excluding patients with bronchospastic disease, congestive heart failure or other contraindications to beta blocker therapy.

In patients with migraine the incidence of bradycardia was 5 percent.

In a coronary artery disease population studied in the Norwegian multi-center trial, the frequency of the principal adverse reactions and the frequency with which these resulted in discontinuation of therapy in the Timolol Alcon 0.50% and placebo groups were

Adverse Reaction***

WithdrawalOnly principal reason for withdrawal in each patient is listed. These adverse reactions can also occur in patients treated for hypertension.

The following additional adverse effects have been reported in clinical experience with the drug: Body as a Whole: anaphylaxis, extremity pain, decreased exercise tolerance, weight loss, fever; Cardiovascular: cardiac arrest, cardiac failure, cerebral vascular accident, worsening of angina pectoris, worsening of arterial insufficiency, Raynaud's phenomenon, palpitations, vasodilatation; Digestive: gastrointestinal pain, hepatomegaly, vomiting, diarrhea, dyspepsia; Hematologic: nonthrombocytopenic purpura; Endocrine: hyperglycemia, hypoglycemia; Skin: rash, skin irritation, increased pigmentation, sweating, alopecia; Musculoskeletal: arthralgia; Nervous System: local weakness, increase in signs and symptoms of myasthenia gravis; Psychiatric: depression, nightmares, somnolence, insomnia, nervousness, diminished concentration, hallucinations; Respiratory: cough; Special Senses: visual disturbances, diplopia, ptosis, dry eyes; Urogenital: impotence, urination difficulties.

There have been reports of retroperitoneal fibrosis in patients receiving Timolol Alcon 0.50% maleate and in patients receiving other beta-adrenergic blocking agents. A causal relationship between this condition and therapy with beta-adrenergic blocking agents has not been established.

Potential Adverse Effects: In addition, a variety of adverse effects not observed in clinical trials with Timolol Alcon 0.50% (Timolol Alcon 0.50%), but reported with other beta-adrenergic blocking agents, should be considered potential adverse effects of Timolol Alcon 0.50% (Timolol Alcon 0.50%) : Nervous System: Reversible mental depression progressing to catatonia; an acute reversible syndrome characterized by disorientation for time and place, short-term memory loss, emotional lability, slightly clouded sensorium, and decreased performance on neuropsychometrics; Cardiovascular: Intensification of AV block; Digestive: Mesenteric arterial thrombosis, ischemic colitis; Hematologic: Agranulocytosis, thrombocytopenic purpura; Allergic: Erythematous rash, fever combined with aching and sore throat, laryngospasm with respiratory distress; Miscellaneous: Peyronie's disease.

There have been reports of a syndrome comprising psoriasiform skin rash, conjunctivitis sicca, otitis, and sclerosing serositis attributed to the beta-adrenergic receptor blocking agent, practolol. This syndrome has not been reported with Timolol Alcon 0.50% (Timolol Alcon 0.50%).

Clinical Laboratory Test Findings: Clinically important changes in standard laboratory parameters were rarely associated with the administration of Timolol Alcon 0.50% (Timolol Alcon 0.50%). Slight increases in blood urea nitrogen, serum potassium, uric acid, and triglycerides, and slight decreases in hemoglobin, hematocrit and HDL cholesterol occurred, but were not progressive or associated with clinical manifestations. Increases in liver function tests have been reported.

Timolol Alcon 0.50% contraindications

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What is the most important information I should know about Timolol Alcon 0.50%?

Do not stop taking Timolol Alcon 0.50% without first talking to your doctor. Stopping suddenly may make your condition worse.

If you need to have any type of surgery, you may need to temporarily stop using Timolol Alcon 0.50%. Be sure the surgeon knows ahead of time that you are using Timolol Alcon 0.50%.

Timolol Alcon 0.50% can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking Timolol Alcon 0.50%.

Timolol Alcon 0.50% is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension.

Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

Active ingredient matches for Timolol Alcon 0.50%:

Timolol in France.

List of Timolol Alcon 0.50% substitutes (brand and generic names)	Sort by popularity
Unit description / dosage (Manufacturer)	Price, USD
Timolol-POS (Czech Republic, Georgia, Germany, Israel, Poland, Russian Federation, Turkey)
Timolol-Pos 5 mg/1 mL x 5 mL
Timololo Alcon (Italy)
Timololo Bausch & Lomb (Italy)
Timololo Novartis (Italy)
Timololo Tubilux Pharma (Italy)
Timolong
Timolong Eye 3 ml Drop (Intas Pharmaceuticals Ltd.)	$ 0.72
TIMOLONG 0.5% EYE DROP 1 packet / 5 ML eye drop each (Intas Pharmaceuticals Ltd.)	$ 0.92
Timolpres (Argentina)
Timolux (Italy)
Timomann (Germany)
Timomann 0,1% (Germany)
Timomann 0,25% (Germany)
Timomann 0,5% (Germany)
Timomin (Bangladesh)
TIMONA
TIMONA 0.25% EYE DROPS 1 packet / 1 ML eye drop each (Zydus Cadila)	$ 0.56
Timona 0.25% Eye Drop (Zydus Cadila)	$ 0.56
Timoneo (Brazil)
TIMONIX
TIMONIX EYE DROP 1 packet / 5 ML eye drop each (Phoenix Pharmaceuticals)	$ 0.63
Timonorm (Georgia)
Timop (Chile)
Solution; Ophthalmic; Timolol Maleate 0.5% (Laboratorios chile)
TimoPhar (Croatia (Hrvatska))
Timophtal (Austria)
Drops; Ophthalmic; Timolol 0.25%
Drops; Ophthalmic; Timolol 0.5%
Timophtal 0,5% (Austria)
Timophtal Sine
Drops; Ophthalmic; Timolol 0.5%
Timopic
Timoplos (Argentina)
Timopos COMOD (Germany)
Timopres (Colombia)
Timopress (Bangladesh)
TIMOPRESS 0.5% EYE DROPS 1 packet / 5 ML eye drop each (NuLife Pharmaceuticals)	$ 0.39
Timopress 0.5% Eye Drop (NuLife Pharmaceuticals)	$ 0.39
Timoptic 0,25% (Austria)
Timoptic 0,5% (Austria, Poland)
Timoptic XE Gel Eye Drops
Timoptic-XE 0,25% (Switzerland)
Timoptic-XE 0,5% (Switzerland)
Timoptol (Australia, Belgium, Chile, Costa Rica, Czech Republic, Ecuador, El Salvador, Ethiopia, France, Guatemala, Honduras, Ireland, Italy, Japan, Luxembourg, Malaysia, Malta, Mexico, Netherlands, New Zealand, Nicaragua, Oman, Panama, Philippines, Portugal, Singapore, South Africa, Sri Lanka, Taiwan, Thailand, United Kingdom, Venezuela)
Solution; Ophthalmic; Timolol Maleate 0.25% (Santen Pharma)
Solution; Ophthalmic; Timolol Maleate 0.5% (Santen Pharma)
Timoptol 0.25 % x 5 mL (Santen Pharma)
Timoptol 0.5 % x 5 mL (Santen Pharma)
Timoptol -XE 0.25 % x 2.5 mL (Santen Pharma)
Timoptol -XE 0.5 % x 2.5 mL (Santen Pharma)
See 784 substitutes for Timolol Alcon 0.50%

References

1. DailyMed. "TIMOLOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. PubChem. "timolol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
3. DrugBank. "timolol". http://www.drugbank.ca/drugs/DB00373 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Timolol Alcon 0.50% are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Timolol Alcon 0.50%. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology