Dosage of Tobramycin in details
Tobramycin Dosage
Generic name: Tobramycin 300mg in 5mL
Dosage form: inhalation solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Dosing Information
- Tobramycin is a co-packaging of Tobramycin inhalation solution ampules with a PARI LC PLUS Reusable Nebulizer. Administer as follows: One single-use ampule (300 mg /5 mL) of Tobramycin inhalation solution twice a day by oral inhalation in alternating periods of 28 days on drug, followed by 28 days off drug.
- The 300 mg/5mL dose of Tobramycin inhalation solution is the same for all patients regardless of age or weight.
- The doses should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart.
Administration of Tobramycin Inhalation Solution
Each dose of Tobramycin inhalation solution is administered by oral inhalation using only the co-packaged PARI LC PLUS Reusable Nebulizer (Model No. 022B81-T) included in the Tobramycin, along with a DeVilbiss Pulmo-Aide air compressor (Model No. 5650D).
Tobramycin inhalation solution is not for subcutaneous, intravenous or intrathecal administration.
Prior to administration, read the Patient Information/Instructions for Use for Tobramycin for detailed information on how to use Tobramycin and follow the manufacturer's instructions for use and care of the DeVilbiss Pulmo-Aide air compressor.
The entire Tobramycin inhalation solution treatment should take approximately 15 minutes to complete. Continue treatment until all the Tobramycin inhalation solution has been delivered, and there is no longer any mist being produced.
Tobramycin inhalation solution should not be diluted or mixed with other drugs including dornase alfa (Pulmozyme®) in the nebulizer. Instruct patients on multiple therapies to take their medications prior to inhaling the Tobramycin inhalation solution, or as directed by their physician.
Tobramycin inhalation solution should not be used if it is cloudy, if there are particles in the solution, or if it has been stored at room temperature for more than 28 days.
More about Tobramycin (Tobramycin)
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- Generic Availability
Consumer resources
- Tobramycin (Advanced Reading)
- Other brands: Tobramycin, Bethkis, Tobramycin, Nebcin
Professional resources
- Tobramycin (FDA)
- Tobramycin (AHFS Monograph)
Related treatment guides
- Cystic Fibrosis
What other drugs will affect Tobramycin?
Before using Tobramycin, tell your doctor if you are taking:
- furosemide (Lasix);
- ethacryinc acid (Edecrin); or
- mannitol (Osmitrol).
You may not be able to use Tobramycin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Do not mix Tobramycin with dornase alfa (Pulmozyme) in the nebulizer.
Drugs other than those listed here may also interact with Tobramycin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
Tobramycin interactions
No clinical drug interaction studies have been performed with Tobramycin. In clinical studies, patients receiving Tobramycin continued to take dornase alfa, bronchodilators, inhaled corticosteroids, and macrolides. No clinical signs of drug interactions with these medicines were identified.
Concurrent and/or sequential use of Tobramycin with other drugs with neurotoxic, nephrotoxic, or ototoxic potential should be avoided.
Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. Tobramycin should not be administered concomitantly with ethacrynic acid, furosemide, urea, or intravenous mannitol. The interaction between inhaled mannitol and Tobramycin has not been evaluated.
References
- DailyMed. "TOBRAMYCIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "VZ8RRZ51VK: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Tobramycin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Tobramycin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
2 consumers reported frequency of use
How frequently do I need to take Tobramycin?It was reported by ndrugs.com website users that Tobramycin should ideally be taken Twice in a day as the most common frequency of the Tobramycin. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Tobramycin should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
| Users | % | ||
|---|---|---|---|
| Twice in a day | 1 | 50.0% | |
| Once in a day | 1 | 50.0% | |
5 consumers reported doses
What doses of Tobramycin drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Tobramycin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 101-200mg | 2 | 40.0% | |
| 1-5mg | 1 | 20.0% | |
| 11-50mg | 1 | 20.0% | |
| 201-500mg | 1 | 20.0% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
