• Dosage of Tobramycin AN in details
• Tobramycin AN interactions
• Tobramycin AN reviews

Dosage of Tobramycin AN in details

Tobramycin AN Dosage

Generic name: Tobramycin AN 300mg in 5mL

Dosage form: inhalation solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosing Information

• Tobramycin AN is a co-packaging of Tobramycin AN inhalation solution ampules with a PARI LC PLUS Reusable Nebulizer. Administer as follows: One single-use ampule (300 mg /5 mL) of Tobramycin AN inhalation solution twice a day by oral inhalation in alternating periods of 28 days on drug, followed by 28 days off drug.
• The 300 mg/5mL dose of Tobramycin AN inhalation solution is the same for all patients regardless of age or weight.
• The doses should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart.

Administration of Tobramycin AN Inhalation Solution

Each dose of Tobramycin AN inhalation solution is administered by oral inhalation using only the co-packaged PARI LC PLUS Reusable Nebulizer (Model No. 022B81-T) included in the Tobramycin AN, along with a DeVilbiss Pulmo-Aide air compressor (Model No. 5650D).

Tobramycin AN inhalation solution is not for subcutaneous, intravenous or intrathecal administration.

Prior to administration, read the Patient Information/Instructions for Use for Tobramycin AN for detailed information on how to use Tobramycin AN and follow the manufacturer's instructions for use and care of the DeVilbiss Pulmo-Aide air compressor.

The entire Tobramycin AN inhalation solution treatment should take approximately 15 minutes to complete. Continue treatment until all the Tobramycin AN inhalation solution has been delivered, and there is no longer any mist being produced.

Tobramycin AN inhalation solution should not be diluted or mixed with other drugs including dornase alfa (Pulmozyme®) in the nebulizer. Instruct patients on multiple therapies to take their medications prior to inhaling the Tobramycin AN inhalation solution, or as directed by their physician.

Tobramycin AN inhalation solution should not be used if it is cloudy, if there are particles in the solution, or if it has been stored at room temperature for more than 28 days.

More about Tobramycin AN (Tobramycin AN)

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Consumer resources

• Tobramycin AN (Advanced Reading)

• Other brands: Tobramycin AN, Bethkis, Tobramycin AN, Nebcin

Professional resources

• Tobramycin AN (FDA)
• Tobramycin AN Sulfate (AHFS Monograph)

Related treatment guides

• Cystic Fibrosis

What other drugs will affect Tobramycin AN?

Before using Tobramycin AN, tell your doctor if you are taking:

• furosemide (Lasix);
• ethacryinc acid (Edecrin); or
• mannitol (Osmitrol).

You may not be able to use Tobramycin AN, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Do not mix Tobramycin AN with dornase alfa (Pulmozyme) in the nebulizer.

Drugs other than those listed here may also interact with Tobramycin AN. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Tobramycin AN interactions

No clinical drug interaction studies have been performed with Tobramycin AN. In clinical studies, patients receiving Tobramycin AN continued to take dornase alfa, bronchodilators, inhaled corticosteroids, and macrolides. No clinical signs of drug interactions with these medicines were identified.

Concurrent and/or sequential use of Tobramycin AN with other drugs with neurotoxic, nephrotoxic, or ototoxic potential should be avoided.

Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. Tobramycin AN should not be administered concomitantly with ethacrynic acid, furosemide, urea, or intravenous mannitol. The interaction between inhaled mannitol and Tobramycin AN has not been evaluated.

References

1. DailyMed. "TOBRAMYCIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "VZ8RRZ51VK: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology