• Dosage of Tobramycin Sulfate ADD-Vantage in details
• Tobramycin Sulfate ADD-Vantage interactions
• Tobramycin Sulfate ADD-Vantage reviews

Dosage of Tobramycin Sulfate ADD-Vantage in details

Tobramycin Sulfate ADD-Vantage Dosage

Generic name: Tobramycin Sulfate ADD-Vantage 300mg in 5mL

Dosage form: inhalation solution

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Dosing Information

• Tobramycin Sulfate ADD-Vantage is a co-packaging of Tobramycin Sulfate ADD-Vantage inhalation solution ampules with a PARI LC PLUS Reusable Nebulizer. Administer as follows: One single-use ampule (300 mg /5 mL) of Tobramycin Sulfate ADD-Vantage inhalation solution twice a day by oral inhalation in alternating periods of 28 days on drug, followed by 28 days off drug.
• The 300 mg/5mL dose of Tobramycin Sulfate ADD-Vantage inhalation solution is the same for all patients regardless of age or weight.
• The doses should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart.

Administration of Tobramycin Sulfate ADD-Vantage Inhalation Solution

Each dose of Tobramycin Sulfate ADD-Vantage inhalation solution is administered by oral inhalation using only the co-packaged PARI LC PLUS Reusable Nebulizer (Model No. 022B81-T) included in the Tobramycin Sulfate ADD-Vantage, along with a DeVilbiss Pulmo-Aide air compressor (Model No. 5650D).

Tobramycin Sulfate ADD-Vantage inhalation solution is not for subcutaneous, intravenous or intrathecal administration.

Prior to administration, read the Patient Information/Instructions for Use for Tobramycin Sulfate ADD-Vantage for detailed information on how to use Tobramycin Sulfate ADD-Vantage and follow the manufacturer's instructions for use and care of the DeVilbiss Pulmo-Aide air compressor.

The entire Tobramycin Sulfate ADD-Vantage inhalation solution treatment should take approximately 15 minutes to complete. Continue treatment until all the Tobramycin Sulfate ADD-Vantage inhalation solution has been delivered, and there is no longer any mist being produced.

Tobramycin Sulfate ADD-Vantage inhalation solution should not be diluted or mixed with other drugs including dornase alfa (Pulmozyme®) in the nebulizer. Instruct patients on multiple therapies to take their medications prior to inhaling the Tobramycin Sulfate ADD-Vantage inhalation solution, or as directed by their physician.

Tobramycin Sulfate ADD-Vantage inhalation solution should not be used if it is cloudy, if there are particles in the solution, or if it has been stored at room temperature for more than 28 days.

More about Tobramycin Sulfate ADD-Vantage (Tobramycin Sulfate ADD-Vantage)

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Consumer resources

• Tobramycin Sulfate ADD-Vantage (Advanced Reading)

• Other brands: Tobramycin Sulfate ADD-Vantage, Bethkis, Tobramycin Sulfate ADD-Vantage, Nebcin

Professional resources

• Tobramycin Sulfate ADD-Vantage (FDA)
• Tobramycin Sulfate ADD-Vantage Sulfate (AHFS Monograph)

Related treatment guides

• Cystic Fibrosis

What other drugs will affect Tobramycin Sulfate ADD-Vantage?

Before using Tobramycin Sulfate ADD-Vantage, tell your doctor if you are taking:

• furosemide (Lasix);
• ethacryinc acid (Edecrin); or
• mannitol (Osmitrol).

You may not be able to use Tobramycin Sulfate ADD-Vantage, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Do not mix Tobramycin Sulfate ADD-Vantage with dornase alfa (Pulmozyme) in the nebulizer.

Drugs other than those listed here may also interact with Tobramycin Sulfate ADD-Vantage. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Tobramycin Sulfate ADD-Vantage interactions

No clinical drug interaction studies have been performed with Tobramycin Sulfate ADD-Vantage. In clinical studies, patients receiving Tobramycin Sulfate ADD-Vantage continued to take dornase alfa, bronchodilators, inhaled corticosteroids, and macrolides. No clinical signs of drug interactions with these medicines were identified.

Concurrent and/or sequential use of Tobramycin Sulfate ADD-Vantage with other drugs with neurotoxic, nephrotoxic, or ototoxic potential should be avoided.

Some diuretics can enhance aminoglycoside toxicity by altering antibiotic concentrations in serum and tissue. Tobramycin Sulfate ADD-Vantage should not be administered concomitantly with ethacrynic acid, furosemide, urea, or intravenous mannitol. The interaction between inhaled mannitol and Tobramycin Sulfate ADD-Vantage has not been evaluated.

References

1. DailyMed. "TOBRAMYCIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. FDA/SPL Indexing Data. "VZ8RRZ51VK: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
3. MeSH. "Anti-Bacterial Agents". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology