Dosage of Torvalipin in details
Torvalipin Dosage
Generic name: Torvalipin CALCIUM TRIHYDRATE 10mg
Dosage form: tablet, film coated
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Hyperlipidemia (Heterozygous Familial and Nonfamilial) and Mixed Dyslipidemia (Fredrickson Types IIa and IIb)
The recommended starting dose of Torvalipin is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. The dosage range of Torvalipin is 10 to 80 mg once daily. Torvalipin can be administered as a single dose at any time of the day, with or without food. The starting dose and maintenance doses of Torvalipin should be individualized according to patient characteristics such as goal of therapy and response. After initiation and/or upon titration of Torvalipin, lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly.
Heterozygous Familial Hypercholesterolemia in Pediatric Patients (10–17 years of age)
The recommended starting dose of Torvalipin is 10 mg/day; the maximum recommended dose is 20 mg/day (doses greater than 20 mg have not been studied in this patient population). Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more.
Homozygous Familial Hypercholesterolemia
The dosage of Torvalipin in patients with homozygous FH is 10 to 80 mg daily. Torvalipin should be used as an adjunct to other lipid-lowering treatments (e.g., LDL apheresis) in these patients or if such treatments are unavailable.
Concomitant Lipid-Lowering Therapy
Torvalipin may be used with bile acid resins. The combination of HMG-CoA reductase inhibitors (statins) and fibrates should generally be used with caution.
Dosage in Patients With Renal Impairment
Renal disease does not affect the plasma concentrations nor LDL-C reduction of Torvalipin; thus, dosage adjustment in patients with renal dysfunction is not necessary.
Dosage in Patients Taking Cyclosporine, Clarithromycin, Itraconazole, or Certain Protease Inhibitors
In patients taking cyclosporine or the HIV protease inhibitors (tipranavir plus ritonavir) or the hepatitis C protease inhibitor (telaprevir), therapy with Torvalipin should be avoided. In patients with HIV taking lopinavir plus ritonavir, caution should be used when prescribing Torvalipin and the lowest dose necessary employed. In patients taking clarithromycin, itraconazole, or in patients with HIV taking a combination of saquinavir plus ritonavir, darunavir plus ritonavir, fosamprenavir, or fosamprenavir plus ritonavir, therapy with Torvalipin should be limited to 20 mg, and appropriate clinical assessment is recommended to ensure that the lowest dose necessary of Torvalipin is employed. In patients taking the HIV protease inhibitor nelfinavir or the hepatitis C protease inhibitor boceprevir, therapy with Torvalipin should be limited to 40 mg, and appropriate clinical assessment is recommended to ensure that the lowest dose necessary of Torvalipin is employed.
More about Torvalipin (Torvalipin)
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Related treatment guides
- High Cholesterol
- High Cholesterol, Familial Homozygous
- High Cholesterol, Familial Heterozygous
- Prevention of Cardiovascular Disease
- Hyperlipoproteinemia
- More (4) »
What other drugs will affect Torvalipin?
Many drugs can interact with Torvalipin. Below is just a partial list. Tell your doctor if you are using:
- birth control pills;
- cimetidine (Tagamet);
- conivaptan (Vaprisol);
- imatinib (Gleevec);
- isoniazid (for treating tuberculosis);
- spironolactone (Aldactone, Aldactazide);
- an antibiotic such as dalfopristin/quinupristin (Synercid), rifampin (Rifater, Rifadin, Rifamate), telithromycin (Ketek), and others;
- an antidepressant such as nefazodone;
- heart or blood pressure medication such as digoxin (Lanoxin), diltiazem (Cartia, Cardizem), nicardipine (Cardene), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan), and others;
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), indinavir (Crixivan), and others; or
- any other "statin" medication such as amlodipine and Torvalipin (Caduet), fluvastatin (Lescol), lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin).
This list is not complete and there are many other drugs that can increase your risk of serious medical problems if you take them together with Torvalipin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Torvalipin interactions
The risk of myopathy during treatment with statins is increased with concurrent administration of fibric acid derivatives, lipid-modifying doses of niacin, cyclosporine, or strong CYP 3A4 inhibitors (e.g., clarithromycin, HIV protease inhibitors, and itraconazole).
Strong Inhibitors of CYP 3A4
Torvalipin is metabolized by cytochrome P450 3A4. Concomitant administration of Torvalipin with strong inhibitors of CYP 3A4 can lead to increases in plasma concentrations of Torvalipin. The extent of interaction and potentiation of effects depend on the variability of effect on CYP 3A4.
Clarithromycin
Torvalipin AUC was significantly increased with concomitant administration of Torvalipin 80 mg with clarithromycin (500 mg twice daily) compared to that of Torvalipin alone. Therefore, in patients taking clarithromycin, caution should be used when the Torvalipin dose exceeds 20 mg.
Combination of Protease Inhibitors
Torvalipin AUC was significantly increased with concomitant administration of Torvalipin 40 mg with ritonavir plus saquinavir (400 mg twice daily) or Torvalipin 20 mg with lopinavir plus ritonavir (400 mg + 100 mg twice daily) compared to that of Torvalipin alone. Therefore, in patients taking HIV protease inhibitors, caution should be used when the Torvalipin dose exceeds 20 mg.
Itraconazole
Torvalipin AUC was significantly increased with concomitant administration of Torvalipin 40 mg and itraconazole 200 mg. Therefore, in patients taking itraconazole, caution should be used when the Torvalipin dose exceeds 20 mg.
Grapefruit Juice
Contains one or more components that inhibit CYP 3A4 and can increase plasma concentrations of Torvalipin, especially with excessive grapefruit juice consumption ( > 1.2 liters per day).
Cyclosporine
Torvalipin and Torvalipin-metabolites are substrates of the OATP1B1 transporter. Inhibitors of the OATP1B1 (e.g., cyclosporine) can increase the bioavailability of Torvalipin. Torvalipin AUC was significantly increased with concomitant administration of Torvalipin 10 mg and cyclosporine 5.2 mg/kg/day compared to that of Torvalipin alone. In cases where co-administration of Torvalipin with cyclosporine is necessary, the dose of Torvalipin should not exceed 10 mg.
Rifampin or other Inducers of Cytochrome P450 3A4
Concomitant administration of Torvalipin with inducers of cytochrome P450 3A4 (e.g., efavirenz, rifampin) can lead to variable reductions in plasma concentrations of Torvalipin. Due to the dual interaction mechanism of rifampin, simultaneous co-administration of Torvalipin with rifampin is recommended, as delayed administration of Torvalipin after administration of rifampin has been associated with a significant reduction in Torvalipin plasma concentrations.
Digoxin
When multiple doses of Torvalipin and digoxin were coadministered, steady state plasma digoxin concentrations increased by approximately 20%. Patients taking digoxin should be monitored appropriately.
Oral Contraceptives
Co-administration of Torvalipin and an oral contraceptive increased AUC values for norethindrone and ethinyl estradiol. These increases should be considered when selecting an oral contraceptive for a woman taking Torvalipin.
Warfarin
Torvalipin had no clinically significant effect on prothrombin time when administered to patients receiving chronic warfarin treatment.
References
- DailyMed. "AMLODIPINE BESYLATE; ATORVASTATIN CALCIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "A0JWA85V8F: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Hydroxymethylglutaryl-CoA Reductase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Torvalipin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Torvalipin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
1 consumer reported frequency of use
How frequently do I need to take Torvalipin?It was reported by ndrugs.com website users that Torvalipin should ideally be taken Once in a day as the most common frequency of the Torvalipin. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Torvalipin should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
| Users | % | ||
|---|---|---|---|
| Once in a day | 1 | 100.0% | |
6 consumers reported doses
What doses of Torvalipin drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Torvalipin drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 6-10mg | 5 | 83.3% | |
| 1-5mg | 1 | 16.7% | |
Consumer reviews
There are no reviews yet. Be the first to write one! |
Information checked by Dr. Sachin Kumar, MD Pharmacology
