Toxedin Side effects

• Side effects of Toxedin in details
• Toxedin contraindications
• Toxedin reviews

What are the possible side effects of Toxedin?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;

• fever, chills, body aches, flu symptoms;

• chest pain, fast or pounding heartbeats;

• unusual bleeding;

• blood in your urine;

• seizure (convulsions);

• pale or yellowed skin, dark colored urine, fever, confusion or weakness;

• jaundice (yellowing of the skin or eyes);

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

• increased thirst, loss of appetite, swelling, weight gain, feeling short of breath; or

• painful or difficult urination, urinating less than usual or not at all.

Less serious side effects may include:

• nausea, vomiting, stomach pain, mild diarrhea, gas, upset stomach;

• cough, stuffy nose;

• stiff or tight muscles, muscle pain;

• joint pain or swelling;

• headache, drowsiness;

• feeling restless, irritable, or hyperactive;

• white patches or sores inside your mouth or on your lips;

• unusual or unpleasant taste in your mouth;

• diaper rash in an infant taking liquid Toxedin;

• mild itching or skin rash; or

• vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Side effects of Toxedin in details

Toxedin (Toxedin (Toxedin injection) injection) is generally well tolerated. The most common adverse effects have been local reactions following IV administration. Other adverse reactions have been encountered only rarely.

Local Reactions: Thrombophlebitis has occurred with IV administration in 1 in 60 patients.

Gastrointestinal: Gastrointestinal symptoms occurred in 1 in 150 patients and included diarrhea (1 in 220 patients) and nausea (1 in 440 patients). The onset of pseudomembranous colitis may occur during or after antibacterial treatment.

Hypersensitivity Reactions: Hypersensitivity reactions have been reported in fewer than 1% of the patients treated with Toxedin (Toxedin (Toxedin injection) injection) and include rash (1 in 125). Pruritus, urticaria, and positive Coombs' test each occurred in fewer than 1 in 250 patients, and, as with other cephalosporins, rare cases of anaphylaxis, drug fever, erythema multiforme, interstitial nephritis, toxic epidermal necrolysis, and Stevens-Johnson syndrome have occurred.

Blood: A decrease in hemoglobin and hematocrit has been observed in 1 in 10 patients and transient eosinophilia in 1 in 14 patients. Less common reactions seen were transient neutropenia (fewer than 1 in 100 patients) and leukopenia (1 in 750 patients). A similar pattern and incidence were seen with other cephalosporins used in controlled studies. As with other cephalosporins, there have been rare reports of thrombocytopenia.

Hepatic: Transient rise in SGOT and SGPT (1 in 25 patients), alkaline phosphatase (1 in 50 patients), LDH (1 in 75 patients), and bilirubin (1 in 500 patients) levels has been noted.

Kidney: Elevations in serum creatinine and/or blood urea nitrogen and a decreased creatinine clearance have been observed, but their relationship to Toxedin (Toxedin (Toxedin injection) injection) is unknown.

Postmarketing Experience with Toxedin (Toxedin (Toxedin injection) injection) : In addition to the adverse events reported during clinical trials, the following events have been observed during clinical practice in patients treated with Toxedin (Toxedin (Toxedin injection) injection) and were reported spontaneously. Data are generally insufficient to allow an estimate of incidence or to establish causation.

Neurologic: Seizure.

Non-site specific: Angioedema.

Cephalosporin-class Adverse Reactions: In addition to the adverse reactions listed above that have been observed in patients treated with Toxedin (Toxedin (Toxedin injection) injection), the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:

Adverse Reactions: Vomiting, abdominal pain, colitis, vaginitis including vaginal candidiasis, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, and hemorrhage.

Several cephalosporins, including Toxedin (Toxedin (Toxedin injection) injection), have been implicated in triggering seizures, particularly in patients with renal impairment when the dosage was not reduced. If seizures associated with drug therapy should occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.

Altered Laboratory Tests: Prolonged prothrombin time, pancytopenia, agranulocytosis.

What is the most important information I should know about Toxedin?

• Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Toxedin tablets. Do not treat diarrhea without first checking with your doctor.
• The tablet and oral suspension forms of Toxedin tablets are not equivalent. Do not substitute one for the other.
• Toxedin tablets only works against bacteria; it does not treat viral infections (eg, the common cold).
• Be sure to use Toxedin tablets for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Long-term or repeated use of Toxedin tablets may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Diabetes patients - Toxedin tablets may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Toxedin tablets. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Lab tests, including liver function, kidney function, and complete blood cell count, may be performed while you use Toxedin tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Toxedin tablets should not be used in CHILDREN younger than 3 months old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Toxedin tablets while you are pregnant. Toxedin tablets is found in breast milk. Do not breast-feed while taking Toxedin tablets.

Toxedin contraindications

Toxedin (Toxedin (Toxedin injection) injection) for Injection USP and Dextrose Injection USP is contraindicated in patients with known allergy to the cephalosporin group of antibiotics. Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.

References

1. European Chemicals Agency - ECHA. "Cefuroxime: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
2. NCIt. "Cefuroxime: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
3. KEGG. "Antiinfectives". http://www.genome.jp/kegg-bin/get_ht... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Toxedin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Toxedin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology