U.R.I. Pregnancy

• Pregnancy of U.R.I. in details
• U.R.I. breastfeeding
• U.R.I. reviews

Pregnancy of U.R.I. in details

U.R.I. has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. The Collaborative Perinatal Project monitored 65 first trimester exposures to U.R.I.. Malformations were reported in 10 infants, a statistically significant association. In another 6509 live births, 172 mothers were exposed to Dimetapp (U.R.I., phenylephrine and phenylpropanolamine). Five infants were born with congenital abnormalities resulting in a somewhat higher frequency than normal. U.R.I. is only recommended for use during pregnancy when benefit outweigh risk.

See references

U.R.I. breastfeeding

There are no data on the excretion of U.R.I. into human milk. Many H1-antagonists are excreted in human milk and in general, these medications are not recommended for use during breast-feeding. Side effects in breast-feeding infants may manifest as irritability, disturbed sleeping patterns, drowsiness, hyperexcitability, or excessive crying. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or U.R.I., taking into account the importance of the drug to the mother.

See references

References for pregnancy information

1. "Product Information. Dimetane (U.R.I.)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
2. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
3. Aselton P, Jick H, Milunsky A, Hunter JR, Stergachis A "First-trimester drug use and congenital disorders." Obstet Gynecol 65 (1985): 451-5

References for breastfeeding information

1. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
2. "Product Information. Dimetane (U.R.I.)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
3. Mortimer EA, Jr "Drug toxicity from breast milk?." Pediatrics 60 (1977): 780-1

References

1. PubMed Health. "Brompheniramine (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
2. Human Metabolome Database (HMDB). "Brompheniramine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
3. LiverTox. "Brompheniramine: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". https://livertox.nlm.nih.gov//Bromph... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology