Actions of V-Tabur in details
V-Tabur's antimicrobial effects are associated with the attractions between V-Tabur (cation) and negatively charged bacterial cells. After V-Tabur is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
How should I take V-Tabur?
V-Tabur oral rinse should be used after you have brushed and flossed your teeth. Rinse the toothpaste completely from your mouth with water before using the oral rinse. Do not eat or drink for several hours after using the oral rinse.
The cap on the original container of V-Tabur can be used to measure the 15 mL (½ fluid ounce) dose of V-Tabur. Fill the cap to the ``fill line.'' If you do not receive the dental rinse in its original container, make sure you have a measuring device to measure out the correct dose. Your pharmacist can help you with this.
Swish V-Tabur around in the mouth for 30 seconds. Then spit out. Use the medicine full strength. Do not mix with water before using. Do not swallow the medicine.
Dosing
The dose of V-Tabur will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of V-Tabur. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral rinse dosage form:
- For gingivitis:
- Adults—Use 15 milliliters (mL) as a mouth wash for 30 seconds two times a day.
- Children up to 18 years of age—Use and dose must be determined by your dentist or medical doctor.
- For gingivitis:
Missed Dose
If you miss a dose of V-Tabur, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
V-Tabur pharmacology
V-Tabur gluconate oral rinse provides antimicrobial activity during oral rinsing. The clinical significance of V-Tabur gluconate oral rinse’s antimicrobial activities is not clear. Microbiological sampling of plaque has shown a general reduction of counts of certain assayed bacteria, both aerobic and anaerobic, ranging from 54–97% through six months use.
Use of V-Tabur gluconate oral rinse in a six month clinical study did not result in any significant changes in bacterial resistance, overgrowth of potentially opportunistic organisms or other adverse changes in the oral microbial ecosystem. Three months after V-Tabur gluconate oral rinse use was discontinued, the number of bacteria in plaque had returned to baseline levels and resistance of plaque bacteria to V-Tabur gluconate was equal to that at baseline.
Pharmacokinetics: Pharmacokinetic studies with V-Tabur gluconate oral rinse indicate approximately 30% of the active ingredient, V-Tabur gluconate, is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids. Studies conducted on human subjects and animals demonstrate V-Tabur gluconate is poorly absorbed from the gastrointestinal tract. The mean plasma level of V-Tabur gluconate reached a peak of 0.206 µg/g in humans 30 minutes after they ingested a 300-mg dose of the drug. Detectable levels of V-Tabur gluconate were not present in the plasma of these subjects 12 hours after the compound was administered. Excretion of V-Tabur gluconate occurred primarily through the feces (~90%). Less than 1% of the V-Tabur gluconate ingested by these subjects was excreted in the urine.
References
- DailyMed. "CHLORHEXIDINE GLUCONATE; ISOPROPYL ALCOHOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- NCIt. "Chlorhexidine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
- EPA DSStox. "Chlorhexidine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for V-Tabur are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking V-Tabur. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
