What happens if I overdose Vector Plus?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; fast or slow heartbeat; severe or unusual dizziness or light-headedness; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness); symptoms of dehydration (eg, decreased urination; dry mouth or eyes; fast heartbeat; unusual thirst, tiredness, or weakness).
Proper storage of Vector Plus:
Store Vector Plus at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vector Plus out of the reach of children and away from pets.
Overdose of Vector Plus in details
No specific information is available on the treatment of overdosage with Vector Plus. Treatment is symptomatic and supportive. Therapy with Vector Plus should be discontinued and the patient observed closely. Suggested measures include induction of emesis if ingestion is recent, and correction of dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures.
Losartan (Vector Plus): Limited data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted.
Neither Losartan (Vector Plus) nor the active metabolite can be removed by hemodialysis.
Hydrochlorothiazide (Vector Plus): The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias.
The degree to which Hydrochlorothiazide (Vector Plus) is removed by hemodialysis has not been established.
What should I avoid while taking Vector Plus?
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of Vector Plus.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Do not use potassium supplements or salt substitutes while you are taking Vector Plus, unless your doctor has told you to.
Vector Plus warnings
Fetal Toxicity
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Vector Plus as soon as possible.
Thiazides cross the placental barrier and appear in cord blood. Adverse reactions include fetal or neonatal jaundice, thrombocytopenia.
Hypotension in Volume- or Salt-Depleted Patients
In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Vector Plus. Correct volume or salt depletion prior to administration of Vector Plus. Do not use Vector Plus as initial therapy in patients with intravascular volume depletion.
Impaired Renal Function
Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on Vector Plus. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Vector Plus.
Hypersensitivity
Hypersensitivity reactions to Hydrochlorothiazide (Vector Plus) may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Electrolyte and Metabolic Effects
In double-blind clinical trials of various doses of Vector Plus, the incidence of hypertensive patients who developed hypokalemia (serum potassium <3.5 mEq/L) was 6.7% versus 3.5% for placebo; the incidence of hyperkalemia (serum potassium >5.7 mEq/L) was 0.4% versus 0% for placebo.
Vector Plus contains Hydrochlorothiazide (Vector Plus) which can cause hypokalemia, hyponatremia and hypomagnesemia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. Vector Plus also contains Losartan (Vector Plus) which can cause hyperkalemia. Monitor serum electrolytes periodically.
Hydrochlorothiazide (Vector Plus) may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.
Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy. Because Losartan (Vector Plus) decreases uric acid, Losartan (Vector Plus) in combination with Hydrochlorothiazide (Vector Plus) attenuates the diuretic-induced hyperuricemia.
Hydrochlorothiazide (Vector Plus) decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels.
Acute Myopia and Secondary Angle-Closure Glaucoma
Hydrochlorothiazide (Vector Plus), a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue Hydrochlorothiazide (Vector Plus) as rapidly as possible. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.
Systemic Lupus Erythematosus
Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus.
Postsympathectomy Patients
The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient.
What should I discuss with my healthcare provider before taking Vector Plus?
You should not use Vector Plus if you are allergic to Hydrochlorothiazide (Vector Plus) or Losartan (Vector Plus), if you are unable to urinate.
If you have diabetes, do not use Vector Plus together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).
You may also need to avoid taking Vector Plus with aliskiren if you have kidney disease
To make sure Vector Plus is safe for you, tell your doctor if you have:
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kidney disease;
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liver disease;
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congestive heart failure;
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glaucoma;
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asthma;
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low or high levels of potassium in your blood;
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gout;
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lupus;
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diabetes; or
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an allergy to sulfa drugs or penicillin.
Do not use Vector Plus if you are pregnant. Stop using and tell your doctor right away if you become pregnant. Vector Plus can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control.
It is not known whether Vector Plus passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Vector Plus precautions
Fetal Toxicity
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Vector Plus as soon as possible.
Thiazides cross the placental barrier and appear in cord blood. Adverse reactions include fetal or neonatal jaundice, thrombocytopenia.
Hypotension in Volume- or Salt-Depleted Patients
In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Vector Plus. Correct volume or salt depletion prior to administration of Vector Plus. Do not use Vector Plus as initial therapy in patients with intravascular volume depletion.
Impaired Renal Function
Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on Vector Plus. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Vector Plus.
Hypersensitivity
Hypersensitivity reactions to Hydrochlorothiazide (Vector Plus) may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history.
Electrolyte and Metabolic Effects
In double-blind clinical trials of various doses of Vector Plus, the incidence of hypertensive patients who developed hypokalemia (serum potassium <3.5 mEq/L) was 6.7% versus 3.5% for placebo; the incidence of hyperkalemia (serum potassium >5.7 mEq/L) was 0.4% versus 0% for placebo.
Vector Plus contains Hydrochlorothiazide (Vector Plus) which can cause hypokalemia, hyponatremia and hypomagnesemia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. Vector Plus also contains Losartan (Vector Plus) which can cause hyperkalemia. Monitor serum electrolytes periodically.
Hydrochlorothiazide (Vector Plus) may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.
Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy. Because Losartan (Vector Plus) decreases uric acid, Losartan (Vector Plus) in combination with Hydrochlorothiazide (Vector Plus) attenuates the diuretic-induced hyperuricemia.
Hydrochlorothiazide (Vector Plus) decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels.
Acute Myopia and Secondary Angle-Closure Glaucoma
Hydrochlorothiazide (Vector Plus), a sulfonamide, can cause an idiosyncratic reaction, resulting in acute transient myopia and acute angle-closure glaucoma. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of drug initiation. Untreated acute angle-closure glaucoma can lead to permanent vision loss. The primary treatment is to discontinue Hydrochlorothiazide (Vector Plus) as rapidly as possible. Prompt medical or surgical treatments may need to be considered if the intraocular pressure remains uncontrolled. Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy.
Systemic Lupus Erythematosus
Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus.
Postsympathectomy Patients
The antihypertensive effects of the drug may be enhanced in the postsympathectomy patient.
What happens if I miss a dose of Vector Plus?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
References
- DailyMed. "AMLODIPINE BESYLATE; HYDROCHLOROTHIAZIDE; OLMESARTAN MEDOXOMIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DailyMed. "LOSARTAN POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "hydrochlorothiazide". http://www.drugbank.ca/drugs/DB00999 (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
