Verrutopic AS Actions

• Actions of Verrutopic AS in details
• Verrutopic AS pharmacology
• Verrutopic AS reviews

Actions of Verrutopic AS in details

Verrutopic AS directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Verrutopic AS is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, Verrutopic AS is used in several shampoos used to treat dandruff. Verrutopic AS is also used as an active ingredient in gels which remove verrucas (plantar warts). Verrutopic AS inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.

How should I take Verrutopic AS?

Use Verrutopic AS only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of absorption through the skin and the chance of Verrutopic AS poisoning.

Verrutopic AS is for use only on the skin. Do not get any of it in your eyes, nose, or mouth. Rinse it off with water right away if it does get on these areas.

Before using an OTC acne product for the first time, apply a small amount to one or two small affected areas of the skin for 3 days. If no discomfort occurs, follow the directions on the drug facts label of the product.

If your doctor has ordered an occlusive dressing (airtight covering, such as kitchen plastic wrap) to be applied over Verrutopic AS, make sure you know how to apply it. Since an occlusive dressing will increase the amount of medicine absorbed through your skin and the possibility of Verrutopic AS poisoning, use it only as directed. If you have any questions about this, check with your doctor.

Keep Verrutopic AS away from the eyes and other mucous membranes, such as the mouth and inside of the nose. If you should accidentally get some in your eyes or on other mucous membranes, immediately flush them with water for 15 minutes.

To use the cream, lotion, or ointment:

• Apply enough medicine to cover the affected area, and rub in gently.

To use the gel:

• Before using Verrutopic AS gel, apply wet packs to the affected areas for at least 5 minutes. If you have any questions about this, check with your doctor.
• Apply enough gel to cover the affected areas, and rub in gently.

To use the pad:

• Wipe the pad over the affected areas.
• Do not rinse off medicine after treatment.

To use the plaster for warts, corns, or calluses:

• Verrutopic AS comes with patient instructions. Read them carefully before using.
• Do not use Verrutopic AS on irritated skin or on any area that is infected or reddened. Also, do not use Verrutopic AS if you are a diabetic or if you have poor blood circulation.
• Do not use Verrutopic AS on warts with hair growing from them or on warts on the face, in or on the genital (sex) organs, or inside the nose or mouth. Also do not use on moles or birthmarks. To do so may cause severe irritation.
• Wash the area to be treated and dry thoroughly. Warts may be soaked in warm water for 5 minutes before drying.
• Cut the plaster to fit the wart, corn, or callus and apply.
• For corns and calluses:
  • Repeat every 48 hours as needed for up to 14 days, or as directed by your doctor, until the corn or callus is removed.
  • Corns or calluses may be soaked in warm water for 5 minutes to help in their removal.
• For warts:
  • Depending on the product, either:
    • Apply plaster and repeat every 48 hours as needed, or
      • Apply plaster at bedtime, leave in place for at least 8 hours, remove plaster in the morning, and repeat every 24 hours as needed.
  • Repeat for up to 12 weeks as needed, or as directed by your doctor, until wart is removed.
• If discomfort gets worse during treatment or continues after treatment, or if the wart spreads, check with your doctor.

To use the shampoo:

• Before applying Verrutopic AS, wet the hair and scalp with lukewarm water. Apply enough medicine to work up a lather and rub well into the scalp for 2 or 3 minutes, then rinse. Apply the medicine again and rinse thoroughly.

To use the soap:

• Work up a lather with the soap, using hot water, and scrub the entire affected area with a washcloth or facial sponge or mitt.
• If you are to use this soap in a foot bath, work up rich suds in hot water and soak the feet for 10 to 15 minutes. Then pat dry without rinsing.

To use the topical solution:

• Wet a cotton ball or pad with the topical solution and wipe the affected areas.
• Do not rinse off medicine after treatment.

To use the topical solution for warts, corns, or calluses:

• Verrutopic AS comes with patient instructions. Read them carefully before using.
• Verrutopic AS is flammable. Do not use it near heat or open flame or while smoking.
• Do not use Verrutopic AS on irritated skin or on any area that is infected or reddened. Also, do not use Verrutopic AS if you are a diabetic or if you have poor blood circulation.
• Do not use Verrutopic AS on warts with hair growing from them or on warts on the face, in or on the genital (sex) organs, or inside the nose or mouth. Also do not use on moles or birthmarks. To do so may cause severe irritation.
• Avoid breathing in the vapors from the medicine.
• Wash the area to be treated and dry thoroughly. Warts may be soaked in warm water for 5 minutes before drying.
• Apply the medicine one drop at a time to completely cover each wart, corn, or callus. Let dry.
• For warts—Repeat one or two times a day as needed for up to 12 weeks, or as directed by your doctor, until wart is removed.
• For corns and calluses—Repeat one or two times a day as needed for up to 14 days, or as directed by your doctor, until the corn or callus is removed.
• Corns and calluses may be soaked in warm water for 5 minutes to help in their removal.
• If discomfort gets worse during treatment or continues after treatment, or if the wart spreads, check with your doctor.

Unless your hands are being treated, wash them immediately after applying Verrutopic AS to remove any medicine that may be on them.

Dosing

The dose of Verrutopic AS will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Verrutopic AS. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For topical dosage form (cream):
  • For corns and calluses:
    • Adults—Use the 2 to 10% cream as needed. Use the 25 to 60% cream once every 3 to 5 days.
    • Children 2 years of age and older—Use the 2 to 10% cream as needed. Use the 25 to 60% cream once every 3 to 5 days.
    • Children younger than 2 years of age—Use is not recommended.
• For topical dosage form (gel):
  • For acne:
    • Adults—Use the 0.5 to 5% gel once a day.
    • Children 2 years of age and older—Use the 0.5 to 5% gel once a day.
    • Children younger than 2 years of age—Use is not recommended.
  • For psoriasis:
    • Adults—Use the 5% gel once a day.
    • Children 2 years of age and older—Use the 5% gel once a day.
    • Children younger than 2 years of age—Use is not recommended.
  • For common warts:
    • Adults—Use the 5 to 26% gel one time a day.
    • Children 2 years of age and older—Use the 5 to 26% gel one time a day.
    • Children younger than 2 years of age—Use is not recommended.
• For topical dosage form (lotion):
  • For acne:
    • Adults—Use the 1 to 2% lotion one to three times a day.
    • Children 2 years of age and older—Use the 1 to 2% lotion one to three times a day
    • Children younger than 2 years of age—Use is not recommended.
  • For dandruff and antiseborrhic dermatitis of the scalp:
    • Adults—Use the 1.8 to 2% lotion on the scalp one or two times a day.
    • Children 2 years of age and older—Use the 1.8 to 2% lotion on the scalp one or two times a day.
    • Children younger than 2 years of age—Use is not recommended.
• For topical dosage form (ointment):
  • For acne:
    • Adults—Use the 3 to 6% ointment as needed.
    • Children 2 years of age and older—Use the 3 to 6% ointment as needed.
    • Children younger than 2 years of age—Use is not recommended.
  • For psoriasis and seborrheic dermatitis:
    • Adults—Use the 3 to 10% ointment as needed.
    • Children 2 years of age and older—Use the 3 to 10% ointment as needed.
    • Children younger than 2 years of age—Use is not recommended.
  • For common warts:
    • Adults—Use the 3 to 10% ointment as needed. Use the 25 to 60% ointment one time every 3 to 5 days.
    • Children 2 years of age and older—Use the 3 to 10% ointment as needed. Use the 25 to 60% ointment one time every 3 to 5 days.
    • Children younger than 2 years of age—Use is not recommended.
• For pads dosage form:
  • For acne:
    • Adults—Use one to three times a day.
    • Children 2 years of age and older—Use one to three times a day.
    • Children younger than 2 years of age—Use is not recommended.
• For plaster dosage form:
  • For corns, calluses, common warts, or plantar warts:
    • Adults—Use once a day or once every other day.
    • Children 2 years of age and older—Use once a day or once every other day.
    • Children younger than 2 years of age—Use is not recommended.
• For shampoo dosage form:
  • For dandruff or seborrheic dermatitis of the scalp:
    • Adults—Use on the scalp one or two times a week.
    • Children 2 years of age and older—Use on the scalp one or two times a week.
    • Children younger than 2 years of age—Use is not recommended.
• For soap dosage form:
  • For acne:
    • Adults—Use as needed.
    • Children 2 years of age and older—Use as needed.
    • Children younger than 2 years of age—Use is not recommended.
• For topical solution dosage form:
  • For acne:
    • Adults—Use the 0.5 to 2% topical solution one to three times a day.
    • Children 2 years of age and older—Use the 0.5 to 2% topical solution one to three times a day.
    • Children younger than 2 years of age—Use is not recommended.
  • For common warts and plantar warts:
    • Adults—Use the 5 to 27% topical solution one or two times a day.
    • Children 2 years of age and older—Use the 5 to 27% topical solution one or two times a day.
    • Children younger than 2 years of age—Use is not recommended.
  • For corns and calluses:
    • Adults—Use the 12 to 27% topical solution one or two times a day.
    • Children 2 years of age and older—Use the 12 to 27% topical solution one or two times a day.
    • Children younger than 2 years of age—Use is not recommended.

Missed Dose

If you miss a dose of Verrutopic AS, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Verrutopic AS pharmacology

Verrutopic AS has been shown to produce desquamation of the horny layer of skin while not affecting qualitative or quantitative changes in structure of the viable epidermis. The mechanism of action has been attributed to dissolution of intercellular cement substance. In a study of the percutaneous absorption of Verrutopic AS from Verrutopic AS 6% Foam in four patients with extensive active psoriasis, Taylor and Halprin showed that peak serum levels never exceeded 5 mg/100 mL even though more than 60% of the applied Verrutopic AS was absorbed. Systemic toxic reactions are usually associated with much higher serum levels (30 to 40 mg/100mL). Peak serum levels occurred within 5 hours of the topical application under occlusion. The sites were occluded for 10 hours over the entire body surface below the neck. Since salicylates are distributed in the extracellular space, patients with a contracted extracellular space due to dehydration or diuretics have higher salicylate levels than those with a normal extracellular space..

The major metabolites identified in the urine after topical administration are salicyluric acid (52%), salicylate glucuronides (42%), and free Verrutopic AS (6%). The urinary metabolites after percutaneous absorption differ from those after oral salicylate administration; those derived from percutaneous absorption contain more glucuronides and less salicyluric and Verrutopic AS. Almost 95% of a single dose of salicylate is excreted within 24 hours of its entrance into the extracellular space.

Fifty to eighty percent of salicylate is protein bound to albumin. Salicylates compete with the binding of several drugs and can modify the action of these drugs. By similar competetive mechanisms other drugs can influence the serum levels of salicylate..

References

1. NCIt. "Salicylic Acid: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
2. EPA DSStox. "Salicylic acid: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
3. EPA Chemicals under the TSCA. "Benzoic acid, 2-hydroxy-: The Chemical Data Reporting under the Toxic Substances Control Act (TSCA) contains chemical physical description and chemical use categories.". http://www.epa.gov/chemical-data-rep... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Verrutopic AS are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Verrutopic AS. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology