Dosage of Yalone in details
Oral
Anti-inflammatory or immunosuppressive
Adult: Initially, 2-60 mg daily in 1-4 divided doses, depending on the disease being treated.
Child: As Yalone Na succinate: 0.5-1.7 mg/kg daily or 5-25 mg/m2 daily in divided doses 6-12 hrly. "Pulse" therapy: 15-30 mg/kg/dose over ≥30 min given once daily for 3 days.
Oral
Allergic conditions
Adult: 24 mg on day 1 (8 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime) or 24 mg as a single or in 2-3 divided doses upon initiation (regardless of time of day); 20 mg on day 2 (4 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 8 mg at bedtime); 16 mg on day 3 (4 mg before breakfast, 4 mg after lunch, 4 mg after supper, and 4 mg at bedtime); 12 mg on day 4 (4 mg before breakfast, 4 mg after lunch, and 4 mg at bedtime); 8 mg on day 5 (4 mg before breakfast and 4 mg at bedtime); 4 mg on day 6, given before breakfast.
Intramuscular
Anti-inflammatory or immunosuppressive
Adult: As methyprednisolone Na succinate: 10-80 mg once daily. As Yalone acetate: 10-80 mg every 1-2 wk.
Child: As Yalone Na succinate: 0.5-1.7 mg/kg daily or 5-25 mg/m2 daily in divided doses 6-12 hrly. "Pulse" therapy: 15-30 mg/kg/dose over ≥30 min given once daily for 3 days.
Reconstitution: Methyprednisolone Na succinate: Add bacteriostatic water for inj containing benzyl alcohol 0.9% according to the manufacturer's instructions.
Intravenous
Anti-inflammatory or immunosuppressive
Adult: As Yalone Na succinate: 10-500 mg daily. Doses ≤250 mg are given by inj over at least 5 min while doses >250 mg are given slowly over at least 30 min.
Child: As Yalone Na succinate: 0.5-1.7 mg/kg daily or 5-25 mg/m2 daily in divided doses 6-12 hrly. "Pulse" therapy: 15-30 mg/kg/dose over ≥30 min given once daily for 3 days.
Reconstitution: Methyprednisolone Na succinate: IM/IV inj: Add bacteriostatic water for inj containing benzyl alcohol 0.9% according to the manufacturer's instructions. IV infusion: Dilute further w/ dextrose 5%, NaCl 0.9%, dextrose 5% in NaCl 0.9% inj or other compatible IV soln.
Incompatibility: Y-site: Allopurinol, amsacrine, caspofungin, ciprofloxacin, docetaxel, etoposide phosphate, fenoldopam, filgrastim, gemcitabine, ondansetron, paclitaxel, palonosetron, propofol, sargramostim, tigecycline, vinorelbine.
Intravenous
Status asthmaticus
Adult: As Yalone Na succinate: 40 mg, repeated according to patient's response.
Child: As Yalone Na succinate: 1-4 mg/kg daily for 1-3 days.
Reconstitution: Methyprednisolone Na succinate: IM/IV inj: Add bacteriostatic water for inj containing benzyl alcohol 0.9% according to the manufacturer's instructions. IV infusion: Dilute further w/ dextrose 5%, NaCl 0.9%, dextrose 5% in NaCl 0.9% inj or other compatible IV soln.
Incompatibility: Y-site: Allopurinol, amsacrine, caspofungin, ciprofloxacin, docetaxel, etoposide phosphate, fenoldopam, filgrastim, gemcitabine, ondansetron, paclitaxel, palonosetron, propofol, sargramostim, tigecycline, vinorelbine.
Intra-articular
Anti-inflammatory or immunosuppressive
Adult: As Yalone acetate: 4-10 mg (small joints); 10-40 mg (medium joints); 20-80 mg (large joints). May be repeated every 1-5 wk depending on patient's response.
Anti-inflammatory or immunosuppressive Adult: As Yalone acetate: 20-60 mg every 1-5 wk depending on patient's response. Corticosteroid-responsive dermatoses Adult: As Yalone acetate: 20-60 mg; 1-4 inj may be given at intervals depending on the type of lesion and the duration of improvement from the initial inj. Acute allograft rejection in organ transplant recipients Adult: As Yalone Na succinate: 0.5-1 g daily; continue until the patient has stabilised, usually not beyond 48-72 hr. Child: As Yalone Na succinate: 10-20 mg/kg daily for up to 3 days. Max: 1,000 mg daily. Reconstitution: Methyprednisolone Na succinate: IM/IV inj: Add bacteriostatic water for inj containing benzyl alcohol 0.9% according to the manufacturer's instructions. IV infusion: Dilute further w/ dextrose 5%, NaCl 0.9%, dextrose 5% in NaCl 0.9% inj or other compatible IV soln. Incompatibility: Y-site: Allopurinol, amsacrine, caspofungin, ciprofloxacin, docetaxel, etoposide phosphate, fenoldopam, filgrastim, gemcitabine, ondansetron, paclitaxel, palonosetron, propofol, sargramostim, tigecycline, vinorelbine. Corticosteroid-responsive dermatoses Adult: As 0.1% Yalone aceponate oint, cream or lotion: Apply thinly to affected area once daily for up to 12 wk. Child: As 0.1% Yalone aceponate oint, cream or lotion: Apply thinly to affected area once daily for up to 4 wk. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Yalone, especially: aspirin (taken on a daily basis or at high doses); cyclosporine; insulin or oral diabetes medication; St. John's wort; antifungal medication--itraconazole, ketoconazole; or HIV/AIDS medication--efavirenz, nevirapine, ritonavir; seizure medication--phenobarbital, phenytoin, and others; or tuberculosis medication--rifabutin, rifampin, rifapentine. This list is not complete. Other drugs may interact with Yalone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Yalone is a cytochrome P-450 enzyme (CYP) substrate and is mainly metabolized by the CYP3A4 enzyme. CYP3A4 is the dominant enzyme of the most abundant CYP subfamily in the liver of adult humans. It catalyzes 6β-hydroxylation of steroids, the essential phase I metabolic step for both endogenous and synthetic corticosteroids. Many other compounds are also substrates of CYP3A4, some of which (as well as other drugs) have been shown to alter glucocorticoid metabolism by induction (upregulation) or inhibition of the CYP3A4 enzyme. CYP3A4 Inhibitors: Drugs that inhibit CYP3A4 activity generally decreased hepatic clearance and increased plasma concentration of CYP3A4 substrate medications eg, Yalone. In the presence of a CYP3A4 inhibitor, the dose of Yalone may need to be titrated to avoid steroid toxicity. CYP3A4 Inducers: Drugs that induce CYP3A4 activity generally increase hepatic clearance, resulting in decreased plasma concentration of medications that are substrates for CYP3A4. Co-administration may require an increase in Yalone dosage to achieve the desired result. CYP3A4 Substrates: In the presence of another CYP3A4 substrate, the hepatic clearance of Yalone may be affected, with corresponding dosage adjustments required. It is possible that adverse events associated with the use of either drug alone may be more likely to occur with co-administration. Non-CYP3A4-Mediated Effects: Other interactions and effects that occur with Yalone. Table 3 provides a list and descriptions of the most common and/or clinically important drug interactions or effects with Yalone. Incompatibilities: To avoid compatibility and stability problems, it is recommended that Yalone sodium succinate be administered separately from other compounds that are administered via the IV route of administration. Drugs that are physically incompatible in solution with Yalone sodium succinate include but are not limited to: Allopurinol sodium, doxapram hydrochloride, tigecycline, diltiazem hydrochloride, calcium gluconate, vecuronium bromide, rocuronium bromide, cisatracurium besylate, glycopyrrolate, propofol. The IV compatibility and stability of Yalone sodium succinate solutions and with other drugs in IV admixtures is dependent on admixture pH, concentration, time, temperature and the ability of Yalone to solubilize itself. Thus, to avoid compatibility and stability problems, whenever possible it is recommended that Yalone sodium succinate be administered separately from other drugs and as either IV push, through an IV medication chamber, or as an IV "piggy-back" solution. Information checked by Dr. Sachin Kumar, MD PharmacologyIntravenous
Topical/Cutaneous
What other drugs will affect Yalone?
Yalone interactions
References
Reviews
The results of a survey conducted on ndrugs.com for Yalone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Yalone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners. User reports
Consumer reported frequency of use
No survey data has been collected yet
1 consumer reported doses
What doses of Yalone drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Yalone drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users % 6-10mg 1 100.0%
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