What is Yi Wei Tuo?
Yi Wei Tuo is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Yi Wei Tuo is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.
Yi Wei Tuo is also used to treat itching and swelling caused by chronic urticaria (hives).
Yi Wei Tuo may also be used for purposes not listed in this medication guide.
Yi Wei Tuo indications
Perennial Allergic Rhinitis: Yi Wei Tuo hydrochloride syrup is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in children 6 to 23 months of age. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.
Chronic Urticaria: Yi Wei Tuo hydrochloride syrup is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in children 6 months to 5 years of age. It significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.
How should I use Yi Wei Tuo?
Use Yi Wei Tuo orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Do not remove the blister unit from the carton until you are ready to take Yi Wei Tuo orally disintegrating tablets. Make sure that your hands are dry when you open the blister unit. Do not push the tablet through the foil. Peel back the foil on the blister unit and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Yi Wei Tuo orally disintegrating tablets may be taken with or without water. Take the tablet immediately after opening the blister unit. Do not store the removed tablet for future use.
- If you miss a dose of Yi Wei Tuo orally disintegrating tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Yi Wei Tuo orally disintegrating tablets.
Uses of Yi Wei Tuo in details
Use: Labeled Indications
Oral:
Allergic rhinitis: Relief of symptoms associated with allergic rhinitis.
Urticaria, chronic spontaneous: Treatment of uncomplicated skin manifestations of chronic spontaneous urticaria.
Injection:
Urticaria, acute: Treatment of acute urticaria.
Off Label Uses
Anaphylaxis (adjunct to epinephrine for relief of cutaneous symptoms)
Based on joint guidelines from the American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asthma & Immunology, and Joint Council of Allergy, Asthma and Immunology on the diagnosis and management of anaphylaxis and guidelines from the World Allergy Organization on anaphylaxis, Yi Wei Tuo may be used as adjunctive treatment, although should not be used as monotherapy or as first-line therapy of anaphylaxis.
Angioedema, acute allergic or recurrent idiopathic
Clinical experience suggests the utility of second-generation H receptor antagonists (eg, Yi Wei Tuo) for the treatment of acute allergic or recurrent idiopathic angioedema.
Yi Wei Tuo description
Yi Wei Tuo HCl is a piperazine derivative and a metabolite of hydroxyzine. It competes reversibly with histamine to block the histamine (H1) receptor sites. Yi Wei Tuo HCl is considered a long-acting nonsedating antihistamine and has some mast-cell stabilizing activity.
Yi Wei Tuo dosage
Yi Wei Tuo Dosage
Applies to the following strength(s): 10 mg; 5 mg; 1 mg/mL
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
- Allergic Rhinitis
- Urticaria
Usual Pediatric Dose for:
- Allergic Rhinitis
- Urticaria
Additional dosage information:
- Renal Dose Adjustments
- Liver Dose Adjustments
- Precautions
- Dialysis
Usual Adult Dose for Allergic Rhinitis
5 to 10 mg orally or chewed once a day
Usual Adult Dose for Urticaria
5 to 10 mg orally or chewed once a day
Usual Pediatric Dose for Allergic Rhinitis
6 months to 2 years: 2.5 mg orally once a day, 12 months and older may be increased to 2.5 mg orally twice a day.
2 to 5 years: 2.5 mg orally once a day, may be increased to 5 mg/day in 1 to 2 divided doses.
6 years or older: 5 to 10 mg orally or chewed once a day.
Usual Pediatric Dose for Urticaria
6 months to 2 years: 2.5 mg orally once a day, 12 months and older may be increased to 2.5 mg orally twice a day.
2 to 5 years: 2.5 mg orally once a day, may be increased to 5 mg/day in 1 to 2 divided doses.
6 years or older: 5 to 10 mg orally or chewed once a day.
Renal Dose Adjustments
CrCl less than 30 mL/min: 5 mg orally or chewed once a day.
Use of Yi Wei Tuo is not recommended in children under 6 years of age with renal impairment due to the difficulty in reliably administering doses less than 2.5 mg (1/2 teaspoonful) and the lack of pharmacokinetic and safety information of Yi Wei Tuo in such patients.
Liver Dose Adjustments
5 mg orally or chewed once a day
Use of Yi Wei Tuo is not recommended in children under 6 years of age with hepatic impairment due to the difficulty in reliably administering doses less than 2.5 mg (1/2 teaspoonful) and the lack of pharmacokinetic and safety information of Yi Wei Tuo in such patients.
Precautions
In clinical trials, the occurrence of somnolence has been reported. Due caution should therefore be exercised when driving a car or operating potential dangerous machinery. Concurrent use of alcohol or other CNS depressants should be avoided because additional reductions in alertness and additional impairment of CNS performance may occur.
Dialysis
Yi Wei Tuo is not significantly removed by hemodialysis, thus supplementary dosing is not required following hemodialysis. The recommended dosage for patients on hemodialysis is 5 mg orally or chewed once a day.
More about Yi Wei Tuo
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
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- Support Group
- Pricing & Coupons
- 139 Reviews - Add your own review/rating
Consumer resources
- Yi Wei Tuo
- Yi Wei Tuo chewable tablets
- Yi Wei Tuo orally disintegrating tablets
- Yi Wei Tuo solution
- Other brands: Zyrtec, Children's Zyrtec, Zyrtec Hives, Yi Wei Tuo, More (1) »
Professional resources
- Yi Wei Tuo Hydrochloride (AHFS Monograph)
- More (8) »
Related treatment guides
- Allergic Rhinitis
- Urticaria
Yi Wei Tuo interactions
See also:
What other drugs will affect Yi Wei Tuo?
Tablet: Concurrent use with alcohol may potentiate the CNS depressant effects of Yi Wei Tuo; maprotiline or tricyclic antidepressants may potentiate the anticholinergic effects of either these medications or Yi Wei Tuo.
Monoamine oxidase (MAO) inhibitors are not recommended because the use may prolong and intensify the anticholinergic and CNS depressant effects of Yi Wei Tuo.
Concurrent use with ototoxic medications may mask the symptoms of ototoxicity eg, tinnitus, dizziness or vertigo; photosensitizing medications may cause additive photosensitizing effects.
Syrup: No interaction is observed for Yi Wei Tuo with pseudoephedrine, cimetidine, ketoconazole, erythromycin and azithromycin. Small decrease in Yi Wei Tuo clearance is observed when theophylline (400 mg once daily) is taken with Yi Wei Tuo. However, disposition of theophylline was not altered by concomitant Yi Wei Tuo administration. Concomitant administration of Yi Wei Tuo and macrolides or ketoconazole has never resulted clinically relevant EGG changes. Extent of exposure to Yi Wei Tuo was increased by 40% when ritonavir is taken with Yi Wei Tuo. Disposition of ritonavir was slightly altered further to concomitant Yi Wei Tuo administration.
Yi Wei Tuo side effects
See also:
What are the possible side effects of Yi Wei Tuo?
Pediatric studies were conducted with Yi Wei Tuo hydrochloride. More than 1300 pediatric patients aged 6 to 11 years with more than 900 treated with Yi Wei Tuo hydrochloride at doses of 1.25 to 10 mg per day were included in controlled and uncontrolled clinical trials conducted in the United States. The duration of treatment ranged from 2 to 12 weeks. Placebo-controlled trials up to 4 weeks duration included 168 pediatric patients aged 2 to 5 years who received Yi Wei Tuo, the majority of whom received single daily doses of 5 mg. A placebo-controlled trial 18 months in duration included 399 patients aged 12 to 24 months treated with Yi Wei Tuo (0.25 mg/kg bid), and another placebo-controlled trial of 7 days duration included 42 patients aged 6 to 11 months who were treated with Yi Wei Tuo (0.25 mg/kg bid).
The majority of adverse reactions reported in pediatric patients aged 2 to 11 years with Yi Wei Tuo hydrochloride were mild or moderate. In placebo-controlled trials, the incidence of discontinuations due to adverse reactions in pediatric patients receiving up to 10 mg of Yi Wei Tuo hydrochloride was uncommon (0.4% on Yi Wei Tuo hydrochloride vs. 1.0% on placebo).
Table 1 lists adverse experiences which were reported for Yi Wei Tuo hydrochloride 5 and 10 mg in pediatric patients aged 6 to 11 years in placebo-controlled clinical trials in the United States and were more common with Yi Wei Tuo hydrochloride than placebo. Of these, abdominal pain was considered treatment-related and somnolence appeared to be dose-related, 1.3% in placebo, 1.9% at 5 mg and 4.2% at 10 mg. The adverse experiences reported in pediatric patients aged 2 to 5 years in placebo-controlled trials were qualitatively similar in nature and generally similar in frequency to those reported in trials with children aged 6 to 11 years.
In the placebo-controlled trials of pediatric patients 6 to 24 months of age, the incidences of adverse experiences, were similar in the Yi Wei Tuo and placebo treatment groups in each study. Somnolence occurred with essentially the same frequency in patients who received Yi Wei Tuo hydrochloride and patients who received placebo. In a study of 1 week duration in children 6 to 11 months of age, patients who received Yi Wei Tuo exhibited greater irritability/fussiness than patients on placebo. In a study of 18 months duration in patients 12 months and older, insomnia occurred more frequently in patients who received Yi Wei Tuo compared to patients who received placebo (9.0% v. 5.3%). In those patients who received 5 mg or more per day of Yi Wei Tuo as compared to patients who received placebo, fatigue (3.6% v. 1.3%) and malaise (3.6% v. 1.8%) occurred more frequently.
Table 1.
Adverse Experiences Reported in Pediatric Patients Aged 6 to 11 Years in Placebo-Controlled United States Yi Wei Tuo Hydrochloride Trials (5 or 10 mg Dose) Which Occurred at a Frequency of ≥2% in Either the 5-mg or the 10-mg Yi Wei Tuo Hydrochloride Group, and More Frequently Than in the Placebo Group
| Adverse Experiences | Placebo (N=309) | Yi Wei Tuo Hydrochloride | |
| 5 mg (N=161) | 10 mg (N=215) | ||
| Headache | 12.3% | 11.0% | 14.0% |
| Pharyngitis | 2.9% | 6.2% | 2.8% |
| Abdominal pain | 1.9% | 4.4% | 5.6% |
| Coughing | 3.9% | 4.4% | 2.8% |
| Somnolence | 1.3% | 1.9% | 4.2% |
| Diarrhea | 1.3% | 3.1% | 1.9% |
| Epistaxis | 2.9% | 3.7% | 1.9% |
| Bronchospasm | 1.9% | 3.1% | 1.9% |
| Nausea | 1.9% | 1.9% | 2.8% |
| Vomiting | 1.0% | 2.5% | 2.3% |
The following events were observed infrequently (less than 2%), in either 3982 adults and children 12 years and older or in 659 pediatric patients aged 6 to 11 years who received Yi Wei Tuo hydrochloride in U.S. trials, including an open adult study of six months duration. A causal relationship of these infrequent events with Yi Wei Tuo hydrochloride administration has not been established.
Autonomic Nervous System: anorexia, flushing, increased salivation, urinary retention.
Cardiovascular: cardiac failure, hypertension, palpitation, tachycardia.
Central and Peripheral Nervous Systems: abnormal coordination, ataxia, confusion, dysphonia, hyperesthesia, hyperkinesia, hypertonia, hypoesthesia, leg cramps, migraine,
myelitis, paralysis, paresthesia, ptosis, syncope, tremor, twitching, vertigo, visual field defect.
Gastrointestinal: abnormal hepatic function, aggravated tooth caries, constipation, dyspepsia, eructation, flatulence, gastritis, hemorrhoids, increased appetite, melena, rectal hemorrhage, stomatitis including ulcerative stomatitis, tongue discoloration, tongue edema.
Genitourinary: cystitis, dysuria, hematuria, micturition frequency, polyuria, urinary incontinence, urinary tract infection.
Hearing and Vestibular: deafness, earache, ototoxicity, tinnitus.
Metabolic/Nutritional: dehydration, diabetes mellitus, thirst.
Musculoskeletal: arthralgia, arthritis, arthrosis, muscle weakness, myalgia.
Psychiatric: abnormal thinking, agitation, amnesia, anxiety, decreased libido, depersonalization, depression, emotional lability, euphoria, impaired concentration, insomnia, nervousness, paroniria, sleep disorder.
Respiratory System: bronchitis, dyspnea, hyperventilation, increased sputum, pneumonia, respiratory disorder, rhinitis, sinusitis, upper respiratory tract infection.
Reproductive: dysmenorrhea, female breast pain, intermenstrual bleeding, leukorrhea, menorrhagia, vaginitis.
Reticuloendothelial: lymphadenopathy.
Skin: acne, alopecia, angioedema, bullous eruption, dermatitis, dry skin, eczema, erythematous rash, furunculosis, hyperkeratosis, hypertrichosis, increased sweating, maculopapular rash, photosensitivity reaction, photosensitivity toxic reaction, pruritus, purpura, rash, seborrhea, skin disorder, skin nodule, urticaria.
Special Senses: parosmia, taste loss, taste perversion.
Vision: blindness, conjunctivitis, eye pain, glaucoma, loss of accommodation, ocular hemorrhage, xerophthalmia.
Body as a Whole: accidental injury, asthenia, back pain, chest pain, enlarged abdomen, face edema, fever, generalized edema, hot flashes, increased weight, leg edema, malaise, nasal polyp, pain, pallor, periorbital edema, peripheral edema, rigors.
Occasional instances of transient, reversible hepatic transaminase elevations have occurred during Yi Wei Tuo therapy. Hepatitis with significant transaminase elevation and elevated bilirubin in association with the use of Yi Wei Tuo hydrochloride has been reported.
Post-Marketing Experience
In the post-marketing experience period, the following additional rare, but potentially severe adverse events have been reported: aggressive reaction, anaphylaxis, cholestasis, convulsions, glomerulonephritis, hallucinations, hemolytic anemia, hepatitis, orofacial dyskinesia, severe hypotension, stillbirth, suicidal ideation, suicide and thrombocytopenia.
Yi Wei Tuo contraindications
See also:
What is the most important information I should know about Yi Wei Tuo?
Tablet: Yi Wei Tuo should not be used except under special circumstances for patients with hepatic and renal function impairment.
The risk-benefit should be considered when medical problems eg, bladder neck obstruction, prostatic hypertrophy, urinary retention and glaucoma exists.
Syrup: Hypersensitivity to Yi Wei Tuo dihydrochloride, hydroxyzine, any piperazine derivatives or to any of the excipients of Yi Wei Tuo. Patients with severe renal impairment CrCl <10 mL/min. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Yi Wei Tuo.
Active ingredient matches for Yi Wei Tuo:
Cetirizine in China.
List of Yi Wei Tuo substitutes (brand and generic names) | Sort by popularity |
| Unit description / dosage (Manufacturer) | Price, USD |
| Yi Meng (China) | |
| Yingxin MeiShu (China) | |
| Z - CET | |
| Z - CET Capsule/ Tablet / 10mg / 10 units (Centaur Laboratories) | $ 0.17 |
| Z Cet | |
| Z Cet 10 mg Tablet (Centaur Drug House Pvt Ltd) | $ 0.02 |
| Zacet | |
| Zacet 10 mg Tablet (Chemo Drugs) | $ 0.01 |
| Zain (Oman) | |
| Zain 10mg (Oman) | |
| Zalicer (Peru) | |
| Zanlan (Bulgaria, El Salvador, Guatemala, Honduras, Nicaragua, Panama) | |
| Zarec (Portugal) | |
| ZCET | |
| ZCET 10MG TABLET 1 strip / 10 tablets each (Centaur Pharmaceuticals Pvt Ltd) | $ 0.17 |
| Zectop | |
| Zectop 10 mg Tablet (Cadila Healthcare (Zydus Cadila Healthcare Ltd)) | $ 0.03 |
| Zeda (Greece) | |
| Zeda 0.5 mg x 1's (Verisfield) | |
| Zeda 1 mg x 1's (Verisfield) | |
| Zene | |
| Zene 10 mg Tablet (Nectar Pharma) | $ 0.02 |
| ZENE 10MG TABLET 1 strip / 10 tablets each (Nectar Pharma) | $ 0.23 |
| Zene 10mg Tablet (Nectar Pharma) | $ 0.02 |
| ZENRID | |
| ZENRID TABLET 1 strip / 10 tablets each (Kaizen Pharmaceuticals Pvt Ltd) | $ 0.24 |
| Zenriz (Indonesia) | |
| Zenriz 10 mg x 30's (Pyridam) | $ 10.23 |
| Zensil (Thailand) | |
| Zensil 10 mg x 1 x 10's (Silom Medical) | |
| Zensil 10 mg x 10 x 10's (Silom Medical) | |
| Zensil 5 mg/5 mL x 60 mL (Silom Medical) | |
| Zensil syr 5 mg/5 mL 60 mL x 1's (Silom Medical) | |
| Zensil tab 10 mg 10's (Silom Medical) | |
| Zensil tab 10 mg 10 x 10's (Silom Medical) | |
| Zensitin (Iceland) | |
| Zeran (Bahrain, Iraq, Jordan, Kuwait, Lebanon, Libya, Nigeria, Oman, Qatar, Saudi Arabia, Sudan, Syria, United Arab Emirates, Yemen) | |
| Zeran 10mg (Oman) | |
| Zericin (Philippines) | |
| Zeridil (Colombia) | |
| ZERITIN | |
| ZERITIN 10MG TABLET 1 strip / 10 tablets each (Shreya Life Sciences Pvt Ltd) | $ 0.04 |
| Zermed (Thailand) | |
| Zermed 10 mg x 10 x 10's (Medicine products) | |
| Zermed 10 mg x 500's (Medicine products) | |
| Zermed 5 mg/5 mL x 60 mL (Medicine products) | |
| Zermed 5 mg/5 mL x 3, 800 mL (Medicine products) | |
| Zertazine (Oman) | |
| Zertazine 10mg (Oman) | |
| Zertazine 5mg/5ml (Oman) | |
| Zertine (Hong Kong, Thailand) | |
| Zertine 10 mg x 10 x 10's (Farmaline) | |
| Zertine 1 mg/1 mL x 60 mL (Farmaline) | |
| Zertine film-coated tab 10 mg 10 x 10's (Farmaline) | |
| Zertine syr 1 mg/mL 60 mL x 1's (Farmaline) | |
See 3022 substitutes for Yi Wei Tuo | |
References
- DailyMed. "CETIRIZINE HYDROCHLORIDE; PSEUDOEPHEDRINE HYDROCHLORIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "cetirizine". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "cetirizine". http://www.drugbank.ca/drugs/DB00341 (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Yi Wei Tuo are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Yi Wei Tuo. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported useful
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Information checked by Dr. Sachin Kumar, MD Pharmacology
